Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323928518> ?p ?o ?g. }
- W4323928518 endingPage "102566" @default.
- W4323928518 startingPage "102566" @default.
- W4323928518 abstract "Maternal n-3 PUFA (omega-3) deficiency can affect brain development in utero and postnatally. Despite the evidence, the impacts of n-3 PUFA deficiency on the expression of neurogenesis genes in the postnatal hippocampus remained elusive. Since postnatal brain development requires PUFAs via breast milk, we examined the fatty acid composition of breast milk and hippocampal expression of neurogenesis genes in n-3 PUFA deficient 21d mice. In addition, the expression of fatty acid desaturases, elongases, free fatty acids signaling receptors, insulin and leptin, and glucose transporters were measured. Among the genes involved in neurogenesis, the expression of brain-specific tenascin-R (TNR) was downregulated to a greater extent (∼31 fold), followed by adenosine A2A receptor (A2AAR), dopamine receptor D2 (DRD2), glial cell line-derived neurotrophic factor (GDNF) expression in the n-3 PUFA deficient hippocampus. Increasing dietary LA to ALA (50:1) elevated the ARA to DHA ratio by ∼8 fold in the n-3 PUFA deficient breast milk, with an overall increase of total n-6/n-3 PUFAs by ∼15:1 (p<0.05) compared to n-3 PUFA sufficient (LA to ALA: 2:1) diet. The n-3 PUFA deficient mice exhibited upregulation of FADS1, FADS2, ELOVL2, ELOVL5, ELOVL6, GPR40, GPR120, LEPR, IGF1 and downregulation of GLUT1, GLUT3, and GLUT4 mRNA expression in hippocampus (p<0.05). Maternal n-3 PUFA deficiency affects the hippocampal expression of key neurogenesis genes in the offspring with concomitant expression of desaturase and elongase genes, suggesting the importance of dietary n-3 PUFA for neurodevelopment." @default.
- W4323928518 created "2023-03-12" @default.
- W4323928518 creator A5037057369 @default.
- W4323928518 creator A5055779928 @default.
- W4323928518 creator A5060350709 @default.
- W4323928518 creator A5072285378 @default.
- W4323928518 creator A5075830733 @default.
- W4323928518 creator A5082115324 @default.
- W4323928518 date "2023-04-01" @default.
- W4323928518 modified "2023-10-14" @default.
- W4323928518 title "Dietary omega-3 fatty acid deficiency from pre-pregnancy to lactation affects expression of genes involved in hippocampal neurogenesis of the offspring" @default.
- W4323928518 cites W1517566746 @default.
- W4323928518 cites W1571556729 @default.
- W4323928518 cites W1573625277 @default.
- W4323928518 cites W1577577364 @default.
- W4323928518 cites W1580807628 @default.
- W4323928518 cites W1793088881 @default.
- W4323928518 cites W1829681736 @default.
- W4323928518 cites W1881886574 @default.
- W4323928518 cites W1904671842 @default.
- W4323928518 cites W1943523944 @default.
- W4323928518 cites W1963641664 @default.
- W4323928518 cites W1964554927 @default.
- W4323928518 cites W1968455009 @default.
- W4323928518 cites W1973490263 @default.
- W4323928518 cites W1977057678 @default.
- W4323928518 cites W1981603264 @default.
- W4323928518 cites W1984854284 @default.
- W4323928518 cites W2000144593 @default.
- W4323928518 cites W2000381670 @default.
- W4323928518 cites W2001429056 @default.
- W4323928518 cites W2008065864 @default.
- W4323928518 cites W2009484631 @default.
- W4323928518 cites W2027724145 @default.
- W4323928518 cites W2032783011 @default.
- W4323928518 cites W2039070728 @default.
- W4323928518 cites W2042027922 @default.
- W4323928518 cites W2049930287 @default.
- W4323928518 cites W2059742736 @default.
- W4323928518 cites W2061658881 @default.
- W4323928518 cites W2063114187 @default.
- W4323928518 cites W2069833326 @default.
- W4323928518 cites W2071412356 @default.
- W4323928518 cites W2084031162 @default.
- W4323928518 cites W2089100905 @default.
- W4323928518 cites W2090244157 @default.
- W4323928518 cites W2090336764 @default.
- W4323928518 cites W2096252044 @default.
- W4323928518 cites W2098503261 @default.
- W4323928518 cites W2104132514 @default.
- W4323928518 cites W2114872517 @default.
- W4323928518 cites W2130512993 @default.
- W4323928518 cites W2132805065 @default.
- W4323928518 cites W2137001845 @default.
- W4323928518 cites W2138548458 @default.
- W4323928518 cites W2140030240 @default.
- W4323928518 cites W2140639390 @default.
- W4323928518 cites W2160315270 @default.
- W4323928518 cites W2171938627 @default.
- W4323928518 cites W2328965215 @default.
- W4323928518 cites W2333641169 @default.
- W4323928518 cites W2410456268 @default.
- W4323928518 cites W2510385140 @default.
- W4323928518 cites W2514509317 @default.
- W4323928518 cites W2555281323 @default.
- W4323928518 cites W2608737760 @default.
- W4323928518 cites W2748742116 @default.
- W4323928518 cites W2767532612 @default.
- W4323928518 cites W2773852483 @default.
- W4323928518 cites W2804174249 @default.
- W4323928518 cites W2944698104 @default.
- W4323928518 cites W2980526739 @default.
- W4323928518 cites W3012286096 @default.
- W4323928518 cites W3082190028 @default.
- W4323928518 cites W3113530421 @default.
- W4323928518 cites W3165118078 @default.
- W4323928518 cites W3170188466 @default.
- W4323928518 cites W3199038415 @default.
- W4323928518 cites W332577946 @default.
- W4323928518 cites W4206327859 @default.
- W4323928518 cites W4211261486 @default.
- W4323928518 cites W4309078581 @default.
- W4323928518 doi "https://doi.org/10.1016/j.plefa.2023.102566" @default.
- W4323928518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36924605" @default.
- W4323928518 hasPublicationYear "2023" @default.
- W4323928518 type Work @default.
- W4323928518 citedByCount "0" @default.
- W4323928518 crossrefType "journal-article" @default.
- W4323928518 hasAuthorship W4323928518A5037057369 @default.
- W4323928518 hasAuthorship W4323928518A5055779928 @default.
- W4323928518 hasAuthorship W4323928518A5060350709 @default.
- W4323928518 hasAuthorship W4323928518A5072285378 @default.
- W4323928518 hasAuthorship W4323928518A5075830733 @default.
- W4323928518 hasAuthorship W4323928518A5082115324 @default.
- W4323928518 hasConcept C112672928 @default.
- W4323928518 hasConcept C126322002 @default.
- W4323928518 hasConcept C134018914 @default.
- W4323928518 hasConcept C19038510 @default.