FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323928669> ?p ?o ?g. }

• W4323928669 endingPage "461" @default.
• W4323928669 startingPage "453" @default.
• W4323928669 abstract "Objectives Four-class drug-resistant (4DR) people living with HIV (PLWH) are a fragile population with a high burden of disease. No data on their inflammation and T-cell exhaustion markers are currently available. Methods Inflammation, immune activation and microbial translocation biomarkers were measured through ELISA in 30 4DR-PLWH with HIV-1 RNA ≥ 50 copies/mL, 30 non-viremic 4DR-PLWH and 20 non-viremic non-4DR-PLWH. Groups were matched by age, gender and smoking habit. T-cell activation and exhaustion markers were assessed by flow cytometry in 4DR-PLWH. An inflammation burden score (IBS) was calculated from soluble marker levels and associated factors were estimated through multivariate regression. Results The highest plasma biomarker concentrations were observed in viremic 4DR-PLWH, the lowest ones in non-4DR-PLWH. Endotoxin core immunoglobulin G showed an opposite trend. Among 4DR-PLWH, CD38/HLA-DR and PD-1 were more expressed on CD4+ (p = 0.019 and 0.034, respectively) and CD8+ (p = 0.002 and 0.032, respectively) cells of viremic compared to non-viremic subjects. An increased IBS was significantly associated with 4DR condition, higher values of viral load and a previous cancer diagnosis. Conclusions Multidrug-resistant HIV infection is associated with a higher IBS, even when viremia is undetectable. Therapeutic approaches aimed to reduce inflammation and T-cell exhaustion in 4DR-PLWH need to be investigated." @default.
• W4323928669 created "2023-03-12" @default.
• W4323928669 creator A5001639111 @default.
• W4323928669 creator A5002487044 @default.
• W4323928669 creator A5005264594 @default.
• W4323928669 creator A5012779792 @default.
• W4323928669 creator A5014136356 @default.
• W4323928669 creator A5049035721 @default.
• W4323928669 creator A5056455614 @default.
• W4323928669 creator A5061040356 @default.
• W4323928669 creator A5071587401 @default.
• W4323928669 creator A5076739061 @default.
• W4323928669 creator A5085639343 @default.
• W4323928669 creator A5089328986 @default.
• W4323928669 date "2023-05-01" @default.
• W4323928669 modified "2023-10-11" @default.
• W4323928669 title "Inflammation burden score in multidrug-resistant HIV-1 infection" @default.
• W4323928669 cites W1555146734 @default.
• W4323928669 cites W1961572327 @default.
• W4323928669 cites W1964999429 @default.
• W4323928669 cites W1977941819 @default.
• W4323928669 cites W1978436252 @default.
• W4323928669 cites W1983818591 @default.
• W4323928669 cites W2002961213 @default.
• W4323928669 cites W2019792586 @default.
• W4323928669 cites W2020054062 @default.
• W4323928669 cites W2035852466 @default.
• W4323928669 cites W2077097954 @default.
• W4323928669 cites W2088541970 @default.
• W4323928669 cites W2088968901 @default.
• W4323928669 cites W2089433024 @default.
• W4323928669 cites W2098836196 @default.
• W4323928669 cites W2115719856 @default.
• W4323928669 cites W2117692326 @default.
• W4323928669 cites W2122483069 @default.
• W4323928669 cites W2141619032 @default.
• W4323928669 cites W2143143335 @default.
• W4323928669 cites W2145476394 @default.
• W4323928669 cites W2147024250 @default.
• W4323928669 cites W2153136696 @default.
• W4323928669 cites W2159360702 @default.
• W4323928669 cites W2162544188 @default.
• W4323928669 cites W2162633432 @default.
• W4323928669 cites W2162694378 @default.
• W4323928669 cites W2171523916 @default.
• W4323928669 cites W2180656014 @default.
• W4323928669 cites W2196013593 @default.
• W4323928669 cites W2312249670 @default.
• W4323928669 cites W2323185049 @default.
• W4323928669 cites W2325442273 @default.
• W4323928669 cites W2327430468 @default.
• W4323928669 cites W2327433604 @default.
• W4323928669 cites W2336908092 @default.
• W4323928669 cites W2432649889 @default.
• W4323928669 cites W2513534886 @default.
• W4323928669 cites W2519879971 @default.
• W4323928669 cites W2531567355 @default.
• W4323928669 cites W2805866094 @default.
• W4323928669 cites W2897264072 @default.
• W4323928669 cites W2897964651 @default.
• W4323928669 cites W2898437655 @default.
• W4323928669 cites W2916708351 @default.
• W4323928669 cites W2921699207 @default.
• W4323928669 cites W2970639874 @default.
• W4323928669 cites W3087790039 @default.
• W4323928669 cites W3107054865 @default.
• W4323928669 doi "https://doi.org/10.1016/j.jinf.2023.03.011" @default.
• W4323928669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36913985" @default.
• W4323928669 hasPublicationYear "2023" @default.
• W4323928669 type Work @default.
• W4323928669 citedByCount "0" @default.
• W4323928669 crossrefType "journal-article" @default.
• W4323928669 hasAuthorship W4323928669A5001639111 @default.
• W4323928669 hasAuthorship W4323928669A5002487044 @default.
• W4323928669 hasAuthorship W4323928669A5005264594 @default.
• W4323928669 hasAuthorship W4323928669A5012779792 @default.
• W4323928669 hasAuthorship W4323928669A5014136356 @default.
• W4323928669 hasAuthorship W4323928669A5049035721 @default.
• W4323928669 hasAuthorship W4323928669A5056455614 @default.
• W4323928669 hasAuthorship W4323928669A5061040356 @default.
• W4323928669 hasAuthorship W4323928669A5071587401 @default.
• W4323928669 hasAuthorship W4323928669A5076739061 @default.
• W4323928669 hasAuthorship W4323928669A5085639343 @default.
• W4323928669 hasAuthorship W4323928669A5089328986 @default.
• W4323928669 hasConcept C10205521 @default.
• W4323928669 hasConcept C126322002 @default.
• W4323928669 hasConcept C142462285 @default.
• W4323928669 hasConcept C159912055 @default.
• W4323928669 hasConcept C167672396 @default.
• W4323928669 hasConcept C203014093 @default.
• W4323928669 hasConcept C2776185481 @default.
• W4323928669 hasConcept C2776252253 @default.
• W4323928669 hasConcept C2776914184 @default.
• W4323928669 hasConcept C2781197716 @default.
• W4323928669 hasConcept C28328180 @default.
• W4323928669 hasConcept C2908647359 @default.
• W4323928669 hasConcept C3013748606 @default.
• W4323928669 hasConcept C54355233 @default.

• next