FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323928791> ?p ?o ?g. }

• W4323928791 endingPage "116" @default.
• W4323928791 startingPage "102" @default.
• W4323928791 abstract "As a pattern recognition receptor which activates innate immune system, toll-like receptor 2 (TLR2) has been reportedly mediates allergic airway inflammation (AAI), yet the underlying mechanism remains elusive. Here, in a murine AAI model, TLR2−/− mice showed decreased airway inflammation, pyroptosis and oxidative stress. RNA-sequencing revealed that allergen-induced hif1 signaling pathway and glycolysis were significantly downregulated when TLR2 was deficient, which were confirmed by lung protein immunoblots. Glycolysis inhibitor 2-Deoxy-d-glucose (2-DG) inhibited allergen-induced airway inflammation, pyroptosis, oxidative stress and glycolysis in wild type (WT) mice, while hif1α stabilizer ethyl 3,4-dihydroxybenzoate (EDHB) restored theses allergen-induced changes in TLR2−/− mice, indicating TLR2-hif1α-mediated glycolysis contributes to pyroptosis and oxidative stress in AAI. Moreover, upon allergen challenge, lung macrophages were highly activated in WT mice but were less activated in TLR2−/− mice, 2-DG replicated while EDHB reversed such effect of TLR2 deficiency on lung macrophages. Likewise, both in vivo and ex vivo WT alveolar macrophages (AMs) exhibited higher TLR2/hif1α expression, glycolysis and polarization activation in response to ovalbumin (OVA), which were all inhibited in TLR2−/− AMs, suggesting AMs activation and metabolic switch are dependent on TLR2. Finally, depletion of resident AMs in TLR2−/− mice abolished while transfer of TLR2−/− resident AMs to WT mice replicated the protective effect of TLR2 deficiency on AAI when administered before allergen challenge. Collectively, we suggested that loss of TLR2-hif1α-mediated glycolysis in resident AMs ameliorates allergic airway inflammation that inhibits pyroptosis and oxidative stress, therefore the TLR2-hif1α-glycolysis axis in resident AMs may be a novel therapeutic target for AAI." @default.
• W4323928791 created "2023-03-12" @default.
• W4323928791 creator A5000510528 @default.
• W4323928791 creator A5011347108 @default.
• W4323928791 creator A5011594486 @default.
• W4323928791 creator A5030514341 @default.
• W4323928791 creator A5038062676 @default.
• W4323928791 creator A5045744491 @default.
• W4323928791 creator A5064126728 @default.
• W4323928791 creator A5075444622 @default.
• W4323928791 creator A5075634564 @default.
• W4323928791 creator A5079659215 @default.
• W4323928791 creator A5080298585 @default.
• W4323928791 date "2023-05-01" @default.
• W4323928791 modified "2023-10-11" @default.
• W4323928791 title "TLR2-hif1α-mediated glycolysis contributes to pyroptosis and oxidative stress in allergic airway inflammation" @default.
• W4323928791 cites W1840868825 @default.
• W4323928791 cites W1864325817 @default.
• W4323928791 cites W1873495658 @default.
• W4323928791 cites W2010697744 @default.
• W4323928791 cites W2012772029 @default.
• W4323928791 cites W2014963245 @default.
• W4323928791 cites W2018434404 @default.
• W4323928791 cites W2029533097 @default.
• W4323928791 cites W2033958147 @default.
• W4323928791 cites W2083292861 @default.
• W4323928791 cites W2136017540 @default.
• W4323928791 cites W2165725087 @default.
• W4323928791 cites W2337739154 @default.
• W4323928791 cites W2566399495 @default.
• W4323928791 cites W2586238008 @default.
• W4323928791 cites W2590899719 @default.
• W4323928791 cites W2728825901 @default.
• W4323928791 cites W2766213880 @default.
• W4323928791 cites W2766704960 @default.
• W4323928791 cites W2795359643 @default.
• W4323928791 cites W2800650242 @default.
• W4323928791 cites W2892377700 @default.
• W4323928791 cites W2899859300 @default.
• W4323928791 cites W2900527042 @default.
• W4323928791 cites W2905023467 @default.
• W4323928791 cites W2946420859 @default.
• W4323928791 cites W2949174534 @default.
• W4323928791 cites W2971243228 @default.
• W4323928791 cites W2981756420 @default.
• W4323928791 cites W3000217587 @default.
• W4323928791 cites W3004453281 @default.
• W4323928791 cites W3012367931 @default.
• W4323928791 cites W3015061049 @default.
• W4323928791 cites W3028463352 @default.
• W4323928791 cites W3032997365 @default.
• W4323928791 cites W3088640807 @default.
• W4323928791 cites W3096438956 @default.
• W4323928791 cites W3118572716 @default.
• W4323928791 cites W3127448978 @default.
• W4323928791 cites W3138204218 @default.
• W4323928791 cites W3159750120 @default.
• W4323928791 cites W3189766576 @default.
• W4323928791 cites W3201207399 @default.
• W4323928791 cites W3203559074 @default.
• W4323928791 cites W3203663965 @default.
• W4323928791 cites W3213770105 @default.
• W4323928791 cites W4226181362 @default.
• W4323928791 cites W4226487406 @default.
• W4323928791 cites W4280542784 @default.
• W4323928791 cites W4282922674 @default.
• W4323928791 cites W4285014209 @default.
• W4323928791 cites W4285042952 @default.
• W4323928791 cites W4285392518 @default.
• W4323928791 doi "https://doi.org/10.1016/j.freeradbiomed.2023.03.007" @default.
• W4323928791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36907255" @default.
• W4323928791 hasPublicationYear "2023" @default.
• W4323928791 type Work @default.
• W4323928791 citedByCount "0" @default.
• W4323928791 crossrefType "journal-article" @default.
• W4323928791 hasAuthorship W4323928791A5000510528 @default.
• W4323928791 hasAuthorship W4323928791A5011347108 @default.
• W4323928791 hasAuthorship W4323928791A5011594486 @default.
• W4323928791 hasAuthorship W4323928791A5030514341 @default.
• W4323928791 hasAuthorship W4323928791A5038062676 @default.
• W4323928791 hasAuthorship W4323928791A5045744491 @default.
• W4323928791 hasAuthorship W4323928791A5064126728 @default.
• W4323928791 hasAuthorship W4323928791A5075444622 @default.
• W4323928791 hasAuthorship W4323928791A5075634564 @default.
• W4323928791 hasAuthorship W4323928791A5079659215 @default.
• W4323928791 hasAuthorship W4323928791A5080298585 @default.
• W4323928791 hasConcept C136449434 @default.
• W4323928791 hasConcept C170493617 @default.
• W4323928791 hasConcept C17172800 @default.
• W4323928791 hasConcept C185592680 @default.
• W4323928791 hasConcept C20251656 @default.
• W4323928791 hasConcept C203014093 @default.
• W4323928791 hasConcept C2776151105 @default.
• W4323928791 hasConcept C2776914184 @default.
• W4323928791 hasConcept C2777209026 @default.
• W4323928791 hasConcept C2781236682 @default.
• W4323928791 hasConcept C55493867 @default.
• W4323928791 hasConcept C62231903 @default.

• next