Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323928824> ?p ?o ?g. }
- W4323928824 abstract "Summary The diagnosis of Parkinsonism is based on motor symptoms that are caused by reduced dopaminergic output. However, decades earlier, patients report non-motoric problems, including hyposmia. It is not known if non-motor and motor defects are causally connected. Using unbiased methods, we identified common synaptic defects in cholinergic neurons across premotor-stage familial fly Parkinson models and in patient samples. These early synaptic defects cause olfactory performance problems. Correcting these defects specifically in olfactory cholinergic interneurons in flies or inducing cholinergic signaling onto Parkinson mutant human induced dopaminergic neurons in vitro using nicotine, both rescue age-dependent dopaminergic neuron decline. Our approach reveals shared pathways of synaptic failure in cholinergic neurons that drive dopaminergic dysfunction across familial Parkinson models." @default.
- W4323928824 created "2023-03-12" @default.
- W4323928824 creator A5001053440 @default.
- W4323928824 creator A5002137087 @default.
- W4323928824 creator A5012386379 @default.
- W4323928824 creator A5014348056 @default.
- W4323928824 creator A5018186657 @default.
- W4323928824 creator A5018784559 @default.
- W4323928824 creator A5035170115 @default.
- W4323928824 creator A5040983698 @default.
- W4323928824 creator A5053420565 @default.
- W4323928824 creator A5064977245 @default.
- W4323928824 creator A5065096295 @default.
- W4323928824 creator A5067528977 @default.
- W4323928824 creator A5081199362 @default.
- W4323928824 date "2023-03-11" @default.
- W4323928824 modified "2023-10-18" @default.
- W4323928824 title "Rescuing early Parkinson-induced hyposmia prevents dopaminergic system failure" @default.
- W4323928824 cites W1622774380 @default.
- W4323928824 cites W1968512862 @default.
- W4323928824 cites W1983103814 @default.
- W4323928824 cites W1986083929 @default.
- W4323928824 cites W1988178943 @default.
- W4323928824 cites W1992264711 @default.
- W4323928824 cites W1994332160 @default.
- W4323928824 cites W1995175147 @default.
- W4323928824 cites W1999292282 @default.
- W4323928824 cites W2001229741 @default.
- W4323928824 cites W2001244299 @default.
- W4323928824 cites W2001560475 @default.
- W4323928824 cites W2007613723 @default.
- W4323928824 cites W2008119714 @default.
- W4323928824 cites W2008830477 @default.
- W4323928824 cites W2009128664 @default.
- W4323928824 cites W2010998231 @default.
- W4323928824 cites W2013044256 @default.
- W4323928824 cites W2018683008 @default.
- W4323928824 cites W2030667534 @default.
- W4323928824 cites W2032972160 @default.
- W4323928824 cites W2037425715 @default.
- W4323928824 cites W2038963685 @default.
- W4323928824 cites W2044908785 @default.
- W4323928824 cites W2053969387 @default.
- W4323928824 cites W2055619740 @default.
- W4323928824 cites W2055646225 @default.
- W4323928824 cites W2069089843 @default.
- W4323928824 cites W2073449985 @default.
- W4323928824 cites W2087485448 @default.
- W4323928824 cites W2092098765 @default.
- W4323928824 cites W2093613378 @default.
- W4323928824 cites W2100894616 @default.
- W4323928824 cites W2104549677 @default.
- W4323928824 cites W2110457518 @default.
- W4323928824 cites W2111015056 @default.
- W4323928824 cites W2114723455 @default.
- W4323928824 cites W2122777481 @default.
- W4323928824 cites W2126478464 @default.
- W4323928824 cites W2135335338 @default.
- W4323928824 cites W2143665683 @default.
- W4323928824 cites W2147988018 @default.
- W4323928824 cites W2149752970 @default.
- W4323928824 cites W2151189936 @default.
- W4323928824 cites W2157535220 @default.
- W4323928824 cites W2158976454 @default.
- W4323928824 cites W2167279371 @default.
- W4323928824 cites W2179438025 @default.
- W4323928824 cites W2225824258 @default.
- W4323928824 cites W2329274529 @default.
- W4323928824 cites W2337697170 @default.
- W4323928824 cites W2527849633 @default.
- W4323928824 cites W2545753590 @default.
- W4323928824 cites W2583361709 @default.
- W4323928824 cites W2601351914 @default.
- W4323928824 cites W2615550277 @default.
- W4323928824 cites W2616641065 @default.
- W4323928824 cites W2754278602 @default.
- W4323928824 cites W2774307122 @default.
- W4323928824 cites W2802685363 @default.
- W4323928824 cites W2807884764 @default.
- W4323928824 cites W2817838603 @default.
- W4323928824 cites W2893681100 @default.
- W4323928824 cites W2911822431 @default.
- W4323928824 cites W2912919723 @default.
- W4323928824 cites W2947715176 @default.
- W4323928824 cites W2948949781 @default.
- W4323928824 cites W2950250779 @default.
- W4323928824 cites W2969948459 @default.
- W4323928824 cites W2986932567 @default.
- W4323928824 cites W2996732250 @default.
- W4323928824 cites W2999498932 @default.
- W4323928824 cites W3010766518 @default.
- W4323928824 cites W3020196375 @default.
- W4323928824 cites W3030942093 @default.
- W4323928824 cites W4205345182 @default.
- W4323928824 cites W4211123396 @default.
- W4323928824 cites W4214861448 @default.
- W4323928824 cites W4225097384 @default.
- W4323928824 cites W4310773007 @default.
- W4323928824 doi "https://doi.org/10.1101/2023.03.11.532176" @default.
- W4323928824 hasPublicationYear "2023" @default.