Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323966227> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4323966227 endingPage "110" @default.
- W4323966227 startingPage "108" @default.
- W4323966227 abstract "The WHO has declared tuberculosis (TB) a global health emergency. Therefore, there is an urgent need to discover and develop new anti-TB drugs. Here we report a new category of 5-substituted pyrimidine nucleosides as potent inhibitors of Mycobacterium tuberculosis growth in vitro. A series of 2'-deoxy-, 3'-azido-2',3'-dideoxy-, and 3'-amino-2',3'-dideoxypyrimidine nucleoside analogues bearing lengthy flexible alkyloxymethyl substituents exhibited marked inhibitory activity against M tuberculosis in vitro. 5-Dodecyloxymethyl-2'-deoxyuridine was found to be a potent inhibitor of M. tuberculosis propagation in vitro. In contrast, monophosphates of the tested nucleosides were devoid of antimycobacterial activity. This new class of inhibitors seems to be a promising chemotherapeutic agent against TB and merits further studies." @default.
- W4323966227 created "2023-03-13" @default.
- W4323966227 creator A5000869763 @default.
- W4323966227 creator A5004964957 @default.
- W4323966227 creator A5012333682 @default.
- W4323966227 creator A5015615727 @default.
- W4323966227 creator A5042107956 @default.
- W4323966227 creator A5083365416 @default.
- W4323966227 creator A5084824744 @default.
- W4323966227 date "2010-03-15" @default.
- W4323966227 modified "2023-10-14" @default.
- W4323966227 title "New 5-Modified Pyrimidine Nucleoside Inhibitors of Mycobacterial Growth" @default.
- W4323966227 doi "https://doi.org/10.32607/20758251-2010-2-1-108-110" @default.
- W4323966227 hasPublicationYear "2010" @default.
- W4323966227 type Work @default.
- W4323966227 citedByCount "6" @default.
- W4323966227 countsByYear W43239662272013 @default.
- W4323966227 countsByYear W43239662272016 @default.
- W4323966227 countsByYear W43239662272021 @default.
- W4323966227 countsByYear W43239662272022 @default.
- W4323966227 crossrefType "journal-article" @default.
- W4323966227 hasAuthorship W4323966227A5000869763 @default.
- W4323966227 hasAuthorship W4323966227A5004964957 @default.
- W4323966227 hasAuthorship W4323966227A5012333682 @default.
- W4323966227 hasAuthorship W4323966227A5015615727 @default.
- W4323966227 hasAuthorship W4323966227A5042107956 @default.
- W4323966227 hasAuthorship W4323966227A5083365416 @default.
- W4323966227 hasAuthorship W4323966227A5084824744 @default.
- W4323966227 hasConcept C142724271 @default.
- W4323966227 hasConcept C185592680 @default.
- W4323966227 hasConcept C202751555 @default.
- W4323966227 hasConcept C2776543447 @default.
- W4323966227 hasConcept C2777975735 @default.
- W4323966227 hasConcept C2779321679 @default.
- W4323966227 hasConcept C2779685592 @default.
- W4323966227 hasConcept C2781069245 @default.
- W4323966227 hasConcept C55493867 @default.
- W4323966227 hasConcept C71924100 @default.
- W4323966227 hasConcept C98274493 @default.
- W4323966227 hasConceptScore W4323966227C142724271 @default.
- W4323966227 hasConceptScore W4323966227C185592680 @default.
- W4323966227 hasConceptScore W4323966227C202751555 @default.
- W4323966227 hasConceptScore W4323966227C2776543447 @default.
- W4323966227 hasConceptScore W4323966227C2777975735 @default.
- W4323966227 hasConceptScore W4323966227C2779321679 @default.
- W4323966227 hasConceptScore W4323966227C2779685592 @default.
- W4323966227 hasConceptScore W4323966227C2781069245 @default.
- W4323966227 hasConceptScore W4323966227C55493867 @default.
- W4323966227 hasConceptScore W4323966227C71924100 @default.
- W4323966227 hasConceptScore W4323966227C98274493 @default.
- W4323966227 hasIssue "1" @default.
- W4323966227 hasLocation W43239662271 @default.
- W4323966227 hasOpenAccess W4323966227 @default.
- W4323966227 hasPrimaryLocation W43239662271 @default.
- W4323966227 hasRelatedWork W2000539430 @default.
- W4323966227 hasRelatedWork W2023337431 @default.
- W4323966227 hasRelatedWork W2050953601 @default.
- W4323966227 hasRelatedWork W2055837608 @default.
- W4323966227 hasRelatedWork W2061879689 @default.
- W4323966227 hasRelatedWork W2524128723 @default.
- W4323966227 hasRelatedWork W2884095943 @default.
- W4323966227 hasRelatedWork W2953424608 @default.
- W4323966227 hasRelatedWork W3028438304 @default.
- W4323966227 hasRelatedWork W3210687582 @default.
- W4323966227 hasVolume "2" @default.
- W4323966227 isParatext "false" @default.
- W4323966227 isRetracted "false" @default.
- W4323966227 workType "article" @default.