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- W4323971542 abstract "Abstract The search for antileishmanial plants used in traditional medicine led to the choice of CH 2 Cl 2 –MeOH (1:1) crude extract of the fruits and stem bark of Pentadesma butyracea Sabine (Clusiaceae) which displayed good activity in vitro against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes during preliminary screening with IC 50 values 5.96 and 26.43 μg mL −1 , respectively. The fractionation of both extracts using flash chromatography yielded active fractions with IC 50 values ranging from 2.71 to 18.88 μg mL −1 . Fourteen compounds ( 1 – 14 ) were isolated from the obtained fractions using successive column chromatographies and their structures were elucidated based on the analysis of their NMR and MS data. Daphnifolin ( 1 ), epicathechin ( 3 ), α-mangostin ( 9 ) and 9-hydroxycalabaxanthone ( 14 ) exhibited potent antileismanial activity against L. donovani 1S (MHOM/SD/62/1S) promastigotes with IC 50 values of 2.01, 9.09, 3.37, and 6.87 μg mL −1 , respectively and good selectivity towards Raw 264.7 macrophage cells (SI > 2.4). Extracts, fractions and some isolates were also assessed in vitro for their antibacterial activity against six bacterial strains [ Salmonella typhi (CPC), Enterobacter cloacae (CPC), Pseudomonas aeruginosa HM801, Staphylococcus aureus ATCC 43300, Streptococcus pneumoniae ATCC 491619, Escherichia coli ATCC 25322] using serial microdilution method. Among the tested samples, the stem bark extract of P. butyracea as well as compounds 2 and 8 showed good to moderate activity against the aforementioned bacterial strains with MIC ≤ 250 μg mL −1 ." @default.
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- W4323971542 date "2021-10-21" @default.
- W4323971542 modified "2023-09-27" @default.
- W4323971542 title "Antileishmanial, antibacterial and cytotoxicity activity of the extracts, fractions, and compounds from the fruits and stem bark extracts of <i>Pentadesma butyracea</i> Sabine" @default.
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- W4323971542 doi "https://doi.org/10.1515/znb-2021-0077" @default.
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