Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323980425> ?p ?o ?g. }
- W4323980425 abstract "Multiple chemotherapies are proposed to cause cell death in part by increasing the steady-state levels of cellular reactive oxygen species (ROS). However, for most of these drugs exactly how the resultant ROS function and are sensed is poorly understood. In particular, it's unclear which proteins the ROS modify and their roles in chemotherapy sensitivity/resistance. To answer these questions, we examined 11 chemotherapies with an integrated proteogenomic approach identifying many unique targets for these drugs but also shared ones including ribosomal components, suggesting one mechanism by which chemotherapies regulate translation. We focus on CHK1 which we find is a nuclear H 2 O 2 sensor that promotes an anti-ROS cellular program. CHK1 acts by phosphorylating the mitochondrial-DNA binding protein SSBP1, preventing its mitochondrial localization, which in turn decreases nuclear H 2 O 2 . Our results reveal a druggable nucleus-to-mitochondria ROS sensing pathway required to resolve nuclear H 2 O 2 accumulation, which mediates resistance to platinum-based chemotherapies in ovarian cancers." @default.
- W4323980425 created "2023-03-13" @default.
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- W4323980425 date "2023-03-11" @default.
- W4323980425 modified "2023-09-27" @default.
- W4323980425 title "Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway" @default.
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