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- W4323980612 endingPage "100084" @default.
- W4323980612 startingPage "100084" @default.
- W4323980612 abstract "Endothelial dysfunction is characterized by a reduction in nitric oxide generation or an unbalanced distribution of the relaxing and contracting pressures produced by endothelial cells. Endothelium was once assumed to be nothing more than a mechanical barrier. Endothelium is now recognized as a tissue that regulates tone, cell formation, leukocyte, thrombocyte, and artery wall contact. The pathophysiologic pathways behind endothelial dysfunction are of great interest, and researchers are working hard to figure out what they are and how they affect diabetes, psoriasis, Inflammatory Bowel Disease, hypertension, heart failure, renal failure, inflammation, stroke, atherosclerosis, and oxidative stress. Inflammatory activation and endothelial dysfunction are important processes in the progression and pathogenesis of atherosclerosis. Endothelial dysfunction in psoriasis patients with arterial hypertension is thought to be caused by a disturbance in the action of L-oxidative arginine's metabolism, as revealed by a decrease in NO bioavailability and a high degree of inactivation, oxidative stress, and an antioxidant state. The failing heart is characterised by irregular cardiac and vascular characteristics caused by abnormalities in NO bioavailability and oxidative stress. In such conditions the bioavailability of the NO can be increased by the various approaches like by using the NO generating compounds which can be done by either through inhalation of NO, use of the hybrid drugs like oral NO-NSAIDs combination or the use of inorganic nitrites. On other hand the endogenous NO levels can be increased by direct delivery of l‑arginine, l‑citrullineor Arginase inhibition. eNOS also can be activated by the use of statins, Corticosteroids, and Second generation β-adrenoceptor antagonists to increase NO level. This review will assist in understanding endothelial dysfunction, its pathogenesis, and its connection to a variety of disorders." @default.
- W4323980612 created "2023-03-13" @default.
- W4323980612 creator A5007484147 @default.
- W4323980612 creator A5012147653 @default.
- W4323980612 creator A5029918189 @default.
- W4323980612 creator A5049214189 @default.
- W4323980612 date "2023-06-01" @default.
- W4323980612 modified "2023-10-14" @default.
- W4323980612 title "Endothelial dysfunction and its relation in different disorders: Recent update" @default.
- W4323980612 cites W1495287184 @default.
- W4323980612 cites W1530200759 @default.
- W4323980612 cites W1643585163 @default.
- W4323980612 cites W1663869364 @default.
- W4323980612 cites W1736794870 @default.
- W4323980612 cites W1937645347 @default.
- W4323980612 cites W1968346496 @default.
- W4323980612 cites W1970646989 @default.
- W4323980612 cites W1978857973 @default.
- W4323980612 cites W1979207224 @default.
- W4323980612 cites W1979948289 @default.
- W4323980612 cites W1983637609 @default.
- W4323980612 cites W1987593270 @default.
- W4323980612 cites W1989690452 @default.
- W4323980612 cites W1993160420 @default.
- W4323980612 cites W2002347993 @default.
- W4323980612 cites W2006796671 @default.
- W4323980612 cites W2012978757 @default.
- W4323980612 cites W2015038984 @default.
- W4323980612 cites W2020706170 @default.
- W4323980612 cites W2022665587 @default.
- W4323980612 cites W2032215495 @default.
- W4323980612 cites W2032832927 @default.
- W4323980612 cites W2038374049 @default.
- W4323980612 cites W2038852529 @default.
- W4323980612 cites W2045378100 @default.
- W4323980612 cites W2048929261 @default.
- W4323980612 cites W2055562012 @default.
- W4323980612 cites W2060887598 @default.
- W4323980612 cites W2063504439 @default.
- W4323980612 cites W2066922594 @default.
- W4323980612 cites W2067902287 @default.
- W4323980612 cites W2069690900 @default.
- W4323980612 cites W2073268517 @default.
- W4323980612 cites W2087790613 @default.
- W4323980612 cites W2091121045 @default.
- W4323980612 cites W2092160468 @default.
- W4323980612 cites W2093529862 @default.
- W4323980612 cites W2093639021 @default.
- W4323980612 cites W2093745102 @default.
- W4323980612 cites W2093803942 @default.
- W4323980612 cites W2101219513 @default.
- W4323980612 cites W2104549050 @default.
- W4323980612 cites W2110926368 @default.
- W4323980612 cites W2119129191 @default.
- W4323980612 cites W2127284954 @default.
- W4323980612 cites W2132651560 @default.
- W4323980612 cites W2133877451 @default.
- W4323980612 cites W2134920273 @default.
- W4323980612 cites W2139113772 @default.
- W4323980612 cites W2154952529 @default.
- W4323980612 cites W2171335969 @default.
- W4323980612 cites W2320262927 @default.
- W4323980612 cites W2397208862 @default.
- W4323980612 cites W2399674801 @default.
- W4323980612 cites W2413293160 @default.
- W4323980612 cites W2486467989 @default.
- W4323980612 cites W2492672367 @default.
- W4323980612 cites W2592371738 @default.
- W4323980612 cites W2609919034 @default.
- W4323980612 cites W2621371007 @default.
- W4323980612 cites W2759050422 @default.
- W4323980612 cites W2794134657 @default.
- W4323980612 cites W2808764647 @default.
- W4323980612 cites W2887139978 @default.
- W4323980612 cites W2888619499 @default.
- W4323980612 cites W2891536507 @default.
- W4323980612 cites W2896861660 @default.
- W4323980612 cites W2901703576 @default.
- W4323980612 cites W2942920090 @default.
- W4323980612 cites W2963971611 @default.
- W4323980612 cites W2965419534 @default.
- W4323980612 cites W2968857461 @default.
- W4323980612 cites W2977696708 @default.
- W4323980612 cites W2983748684 @default.
- W4323980612 cites W2990064790 @default.
- W4323980612 cites W3004047898 @default.
- W4323980612 cites W3006605298 @default.
- W4323980612 cites W3009067370 @default.
- W4323980612 cites W3009204700 @default.
- W4323980612 cites W3013352992 @default.
- W4323980612 cites W3015197361 @default.
- W4323980612 cites W3045013522 @default.
- W4323980612 cites W3081389342 @default.
- W4323980612 cites W3082909140 @default.
- W4323980612 cites W3084758234 @default.
- W4323980612 cites W3085314398 @default.
- W4323980612 cites W3087382850 @default.
- W4323980612 cites W3089772362 @default.