Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323981657> ?p ?o ?g. }
- W4323981657 abstract "Multiple sclerosis (MS) is an autoimmune disease associated with inflammatory demyelination in the central nervous system (CNS). Autologous hematopoietic cell transplantation (HCT) is under investigation as a promising therapy for treatment-refractory MS. Here we identify a reactive myeloid state in chronic experimental autoimmune encephalitis (EAE) mice and MS patients that is surprisingly associated with neuroprotection and immune suppression. HCT in EAE mice leads to an enhancement of this myeloid state, as well as clinical improvement, reduction of demyelinated lesions, suppression of cytotoxic T cells, and amelioration of reactive astrogliosis reflected in reduced expression of EAE- associated gene signatures in oligodendrocytes and astrocytes. Further enhancement of myeloid cell incorporation into the CNS following a modified HCT protocol results in an even more consistent therapeutic effect corroborated by additional amplification of HCT-induced transcriptional changes, underlining myeloid-derived beneficial effects in the chronic phase of EAE. Replacement or manipulation of CNS myeloid cells thus represents an intriguing therapeutic direction for inflammatory demyelinating disease." @default.
- W4323981657 created "2023-03-13" @default.
- W4323981657 creator A5011108715 @default.
- W4323981657 creator A5012357634 @default.
- W4323981657 creator A5016869649 @default.
- W4323981657 creator A5017896511 @default.
- W4323981657 creator A5027893468 @default.
- W4323981657 creator A5034201028 @default.
- W4323981657 creator A5034331200 @default.
- W4323981657 creator A5036572832 @default.
- W4323981657 creator A5037910206 @default.
- W4323981657 creator A5043422771 @default.
- W4323981657 creator A5066446969 @default.
- W4323981657 creator A5071458826 @default.
- W4323981657 creator A5081385535 @default.
- W4323981657 creator A5081666255 @default.
- W4323981657 date "2023-03-12" @default.
- W4323981657 modified "2023-10-16" @default.
- W4323981657 title "Augmentation of a neuroprotective myeloid state by hematopoietic cell transplantation" @default.
- W4323981657 cites W1866421377 @default.
- W4323981657 cites W1977213877 @default.
- W4323981657 cites W1992683442 @default.
- W4323981657 cites W2011856953 @default.
- W4323981657 cites W2049425867 @default.
- W4323981657 cites W2088520442 @default.
- W4323981657 cites W2096423240 @default.
- W4323981657 cites W2098878219 @default.
- W4323981657 cites W2104431737 @default.
- W4323981657 cites W2108335498 @default.
- W4323981657 cites W2125701590 @default.
- W4323981657 cites W2190545194 @default.
- W4323981657 cites W2345377657 @default.
- W4323981657 cites W2411105085 @default.
- W4323981657 cites W2415341492 @default.
- W4323981657 cites W2622807556 @default.
- W4323981657 cites W2626808697 @default.
- W4323981657 cites W2791700208 @default.
- W4323981657 cites W2791954023 @default.
- W4323981657 cites W2797384836 @default.
- W4323981657 cites W2804436811 @default.
- W4323981657 cites W2807609377 @default.
- W4323981657 cites W2898010909 @default.
- W4323981657 cites W2898901335 @default.
- W4323981657 cites W2901838561 @default.
- W4323981657 cites W2904533756 @default.
- W4323981657 cites W2908860845 @default.
- W4323981657 cites W2909840109 @default.
- W4323981657 cites W2911725378 @default.
- W4323981657 cites W2913221496 @default.
- W4323981657 cites W2914720734 @default.
- W4323981657 cites W2914756534 @default.
- W4323981657 cites W2943220296 @default.
- W4323981657 cites W2945306750 @default.
- W4323981657 cites W2949177718 @default.
- W4323981657 cites W2949693884 @default.
- W4323981657 cites W2951560273 @default.
- W4323981657 cites W2955261360 @default.
- W4323981657 cites W2976681669 @default.
- W4323981657 cites W2979979888 @default.
- W4323981657 cites W2981477552 @default.
- W4323981657 cites W2991331878 @default.
- W4323981657 cites W2997280954 @default.
- W4323981657 cites W3002026523 @default.
- W4323981657 cites W3009364942 @default.
- W4323981657 cites W3012139047 @default.
- W4323981657 cites W3022457072 @default.
- W4323981657 cites W3046069960 @default.
- W4323981657 cites W3048533658 @default.
- W4323981657 cites W3087432280 @default.
- W4323981657 cites W3093751863 @default.
- W4323981657 cites W3094093529 @default.
- W4323981657 cites W3099862724 @default.
- W4323981657 cites W3109025853 @default.
- W4323981657 cites W3130700305 @default.
- W4323981657 cites W3132240972 @default.
- W4323981657 cites W3174757275 @default.
- W4323981657 cites W3178987458 @default.
- W4323981657 cites W3197136220 @default.
- W4323981657 cites W3203053031 @default.
- W4323981657 cites W3208672684 @default.
- W4323981657 cites W4205846253 @default.
- W4323981657 cites W4210284585 @default.
- W4323981657 cites W4210632297 @default.
- W4323981657 cites W4212911584 @default.
- W4323981657 cites W4213246543 @default.
- W4323981657 cites W4221042077 @default.
- W4323981657 cites W4226208516 @default.
- W4323981657 cites W4250145052 @default.
- W4323981657 cites W4282838641 @default.
- W4323981657 cites W4296353136 @default.
- W4323981657 cites W4307930330 @default.
- W4323981657 cites W4310599167 @default.
- W4323981657 cites W4315702561 @default.
- W4323981657 doi "https://doi.org/10.1101/2023.03.10.532123" @default.
- W4323981657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36945385" @default.
- W4323981657 hasPublicationYear "2023" @default.
- W4323981657 type Work @default.
- W4323981657 citedByCount "0" @default.
- W4323981657 crossrefType "posted-content" @default.
- W4323981657 hasAuthorship W4323981657A5011108715 @default.