Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324009132> ?p ?o ?g. }
- W4324009132 endingPage "1240" @default.
- W4324009132 startingPage "1228" @default.
- W4324009132 abstract "Myocardial ischemia-reperfusion (I/R) damage is characterized by mitochondrial damage in cardiomyocytes. Transmembrane BAX inhibitor motif containing 6 (TMBIM6) and presenilin-2 (PS2) participate in multiple mitochondrial pathways; thus, we investigated the impact of these proteins on mitochondrial homeostasis during an acute reperfusion injury. Myocardial post-ischemic reperfusion stress impaired myocardial function, induced structural abnormalities and promoted cardiomyocyte death by disrupting the mitochondrial integrity in wild-type mice, but not in TMBIM6 transgenic mice. We found that TMBIM6 bound directly to PS2 and promoted its post-transcriptional degradation. Knocking out PS2 in mice reduced I/R injury-induced cardiac dysfunction, inflammatory responses, myocardial swelling and cardiomyocyte death by improving the mitochondrial integrity. These findings demonstrate that sufficient TMBIM6 expression can prevent PS2 accumulation during cardiac I/R injury, thus suppressing reperfusion-induced mitochondrial damage. Therefore, TMBIM6 and PS2 are promising therapeutic targets for the treatment of cardiac reperfusion damage." @default.
- W4324009132 created "2023-03-14" @default.
- W4324009132 creator A5001428535 @default.
- W4324009132 creator A5022684433 @default.
- W4324009132 creator A5026641678 @default.
- W4324009132 creator A5027418437 @default.
- W4324009132 creator A5038599372 @default.
- W4324009132 creator A5041492302 @default.
- W4324009132 creator A5058382693 @default.
- W4324009132 creator A5060308551 @default.
- W4324009132 creator A5076857904 @default.
- W4324009132 date "2023-01-01" @default.
- W4324009132 modified "2023-09-26" @default.
- W4324009132 title "Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury" @default.
- W4324009132 cites W1824822050 @default.
- W4324009132 cites W1967683520 @default.
- W4324009132 cites W1981642705 @default.
- W4324009132 cites W2000923801 @default.
- W4324009132 cites W2010550564 @default.
- W4324009132 cites W2011454307 @default.
- W4324009132 cites W2039552657 @default.
- W4324009132 cites W2044882968 @default.
- W4324009132 cites W2051395985 @default.
- W4324009132 cites W2059005775 @default.
- W4324009132 cites W2064194904 @default.
- W4324009132 cites W2088274328 @default.
- W4324009132 cites W2088474892 @default.
- W4324009132 cites W2114276035 @default.
- W4324009132 cites W2115437862 @default.
- W4324009132 cites W2121659762 @default.
- W4324009132 cites W2129086716 @default.
- W4324009132 cites W2148491709 @default.
- W4324009132 cites W2168045721 @default.
- W4324009132 cites W2407095306 @default.
- W4324009132 cites W2590635113 @default.
- W4324009132 cites W2616955232 @default.
- W4324009132 cites W2725230559 @default.
- W4324009132 cites W2761646800 @default.
- W4324009132 cites W2768024671 @default.
- W4324009132 cites W2789860518 @default.
- W4324009132 cites W2892205581 @default.
- W4324009132 cites W2925274468 @default.
- W4324009132 cites W2946442337 @default.
- W4324009132 cites W2986755863 @default.
- W4324009132 cites W2994550619 @default.
- W4324009132 cites W2997148129 @default.
- W4324009132 cites W2999600083 @default.
- W4324009132 cites W3003519679 @default.
- W4324009132 cites W3013888723 @default.
- W4324009132 cites W3014625906 @default.
- W4324009132 cites W3015778009 @default.
- W4324009132 cites W3021175073 @default.
- W4324009132 cites W3034300182 @default.
- W4324009132 cites W3037755212 @default.
- W4324009132 cites W3041140855 @default.
- W4324009132 cites W3093231756 @default.
- W4324009132 cites W3096770937 @default.
- W4324009132 cites W3110213240 @default.
- W4324009132 cites W3113358531 @default.
- W4324009132 cites W3114558611 @default.
- W4324009132 cites W3124058153 @default.
- W4324009132 cites W3124200736 @default.
- W4324009132 cites W3139575815 @default.
- W4324009132 cites W3154124261 @default.
- W4324009132 cites W3157571727 @default.
- W4324009132 cites W3170261326 @default.
- W4324009132 cites W3176304998 @default.
- W4324009132 cites W3192746139 @default.
- W4324009132 cites W4200198243 @default.
- W4324009132 cites W4200535239 @default.
- W4324009132 cites W4210735142 @default.
- W4324009132 cites W4210850668 @default.
- W4324009132 cites W4220852828 @default.
- W4324009132 cites W4221083268 @default.
- W4324009132 cites W4282933428 @default.
- W4324009132 cites W4285147169 @default.
- W4324009132 cites W4285198681 @default.
- W4324009132 cites W4285283916 @default.
- W4324009132 cites W4296311848 @default.
- W4324009132 cites W4296372849 @default.
- W4324009132 cites W4313406872 @default.
- W4324009132 doi "https://doi.org/10.7150/ijbs.81100" @default.
- W4324009132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36923943" @default.
- W4324009132 hasPublicationYear "2023" @default.
- W4324009132 type Work @default.
- W4324009132 citedByCount "0" @default.
- W4324009132 crossrefType "journal-article" @default.
- W4324009132 hasAuthorship W4324009132A5001428535 @default.
- W4324009132 hasAuthorship W4324009132A5022684433 @default.
- W4324009132 hasAuthorship W4324009132A5026641678 @default.
- W4324009132 hasAuthorship W4324009132A5027418437 @default.
- W4324009132 hasAuthorship W4324009132A5038599372 @default.
- W4324009132 hasAuthorship W4324009132A5041492302 @default.
- W4324009132 hasAuthorship W4324009132A5058382693 @default.
- W4324009132 hasAuthorship W4324009132A5060308551 @default.
- W4324009132 hasAuthorship W4324009132A5076857904 @default.
- W4324009132 hasBestOaLocation W43240091321 @default.
- W4324009132 hasConcept C102230213 @default.