Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324017536> ?p ?o ?g. }
- W4324017536 endingPage "1098" @default.
- W4324017536 startingPage "1088" @default.
- W4324017536 abstract "Stroke is the primary cause of chronic disability in the elderly, as there are no neurorestorative treatments for those who do not qualify for recanalization therapy. Experimental evidence in stroke animals suggests that transplantation of bone marrow-derived human mesenchymal stem cells (hMSCs) holds promise, but hMSC transplantation has not been systematically tested in aged animals. We tested the hypothesis that poststroke hMSC transplantation improves stroke recovery in aged mice by promoting brain repair.Permanent focal cerebral ischemia was induced in 20-month-old C57BL/6 male mice by distal middle cerebral artery occlusion. Bone marrow-derived hMSCs were expanded in vitro and then administrated intravenously into mice (1×106 cells in PBS) 24 hours after distal middle cerebral artery occlusion. Sensorimotor and cognitive functions, brain atrophy, and brain repair processes (neurogenesis, angiogenesis, oligodendrogenesis) were assessed for up to 56 days after stroke.Poststroke hMSC transplantation did not mitigate brain atrophy or improve neuronal survival at 56 days after distal middle cerebral artery occlusion. However, hMSC-treated mice displayed superior neurobehavioral performances in the open field, rotarod, adhesive removal, novel object, and Morris water maze tests compared with PBS-treated controls. hMSCs promoted white matter integrity and enhanced angiogenesis and oligodendrogenesis-but not neurogenesis-in the stroke brain. Positive correlations between neurobehavioral performance and brain repair profiles or white matter integrity were observed in stroke mice.Poststroke hMSC transplantation improves long-term stroke recovery in aged mice, likely via mechanisms involving enhanced microvascular regeneration and white matter restoration." @default.
- W4324017536 created "2023-03-14" @default.
- W4324017536 creator A5000540211 @default.
- W4324017536 creator A5002792067 @default.
- W4324017536 creator A5005868786 @default.
- W4324017536 creator A5006397681 @default.
- W4324017536 creator A5018999020 @default.
- W4324017536 creator A5020743917 @default.
- W4324017536 creator A5050378035 @default.
- W4324017536 creator A5053435885 @default.
- W4324017536 creator A5069312065 @default.
- W4324017536 creator A5073463968 @default.
- W4324017536 creator A5076770284 @default.
- W4324017536 date "2023-04-01" @default.
- W4324017536 modified "2023-09-27" @default.
- W4324017536 title "Poststroke Intravenous Transplantation of Human Mesenchymal Stem Cells Improves Brain Repair Dynamics and Functional Outcomes in Aged Mice" @default.
- W4324017536 cites W1565170137 @default.
- W4324017536 cites W1979043688 @default.
- W4324017536 cites W1982561969 @default.
- W4324017536 cites W2038399651 @default.
- W4324017536 cites W2074474274 @default.
- W4324017536 cites W2080638375 @default.
- W4324017536 cites W2098459519 @default.
- W4324017536 cites W2529479402 @default.
- W4324017536 cites W2530556582 @default.
- W4324017536 cites W2581532382 @default.
- W4324017536 cites W2801559469 @default.
- W4324017536 cites W2891165428 @default.
- W4324017536 cites W2894454209 @default.
- W4324017536 cites W2898925493 @default.
- W4324017536 cites W2915988618 @default.
- W4324017536 cites W2920941908 @default.
- W4324017536 cites W2933910429 @default.
- W4324017536 cites W2973154975 @default.
- W4324017536 cites W2973160901 @default.
- W4324017536 cites W2981720404 @default.
- W4324017536 cites W3010926230 @default.
- W4324017536 cites W3014895897 @default.
- W4324017536 cites W3022220112 @default.
- W4324017536 cites W3032073814 @default.
- W4324017536 cites W3036827842 @default.
- W4324017536 cites W3047476089 @default.
- W4324017536 cites W3108226754 @default.
- W4324017536 cites W3125243664 @default.
- W4324017536 cites W3125304137 @default.
- W4324017536 cites W3130746614 @default.
- W4324017536 cites W3135423975 @default.
- W4324017536 cites W3138707771 @default.
- W4324017536 cites W3216100692 @default.
- W4324017536 cites W4205679663 @default.
- W4324017536 cites W4210242902 @default.
- W4324017536 cites W4226015327 @default.
- W4324017536 cites W4226455857 @default.
- W4324017536 cites W4231517048 @default.
- W4324017536 doi "https://doi.org/10.1161/strokeaha.122.041507" @default.
- W4324017536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36912142" @default.
- W4324017536 hasPublicationYear "2023" @default.
- W4324017536 type Work @default.
- W4324017536 citedByCount "0" @default.
- W4324017536 crossrefType "journal-article" @default.
- W4324017536 hasAuthorship W4324017536A5000540211 @default.
- W4324017536 hasAuthorship W4324017536A5002792067 @default.
- W4324017536 hasAuthorship W4324017536A5005868786 @default.
- W4324017536 hasAuthorship W4324017536A5006397681 @default.
- W4324017536 hasAuthorship W4324017536A5018999020 @default.
- W4324017536 hasAuthorship W4324017536A5020743917 @default.
- W4324017536 hasAuthorship W4324017536A5050378035 @default.
- W4324017536 hasAuthorship W4324017536A5053435885 @default.
- W4324017536 hasAuthorship W4324017536A5069312065 @default.
- W4324017536 hasAuthorship W4324017536A5073463968 @default.
- W4324017536 hasAuthorship W4324017536A5076770284 @default.
- W4324017536 hasBestOaLocation W43240175361 @default.
- W4324017536 hasConcept C126322002 @default.
- W4324017536 hasConcept C126838900 @default.
- W4324017536 hasConcept C127413603 @default.
- W4324017536 hasConcept C141071460 @default.
- W4324017536 hasConcept C142724271 @default.
- W4324017536 hasConcept C143409427 @default.
- W4324017536 hasConcept C15744967 @default.
- W4324017536 hasConcept C169760540 @default.
- W4324017536 hasConcept C1862650 @default.
- W4324017536 hasConcept C198826908 @default.
- W4324017536 hasConcept C2776361831 @default.
- W4324017536 hasConcept C2778818304 @default.
- W4324017536 hasConcept C2780394083 @default.
- W4324017536 hasConcept C2780645631 @default.
- W4324017536 hasConcept C2781161787 @default.
- W4324017536 hasConcept C2781172350 @default.
- W4324017536 hasConcept C2781192897 @default.
- W4324017536 hasConcept C28328180 @default.
- W4324017536 hasConcept C2911091166 @default.
- W4324017536 hasConcept C44752575 @default.
- W4324017536 hasConcept C4746552 @default.
- W4324017536 hasConcept C541997718 @default.
- W4324017536 hasConcept C54355233 @default.
- W4324017536 hasConcept C71924100 @default.
- W4324017536 hasConcept C78519656 @default.
- W4324017536 hasConcept C86803240 @default.