FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324017926> ?p ?o ?g. }

• W4324017926 abstract "Human epidermal growth factor receptor 2 (ErbB2/HER2) is a tyrosine kinase receptor that is overexpressed in 25% of primary human breast cancers, as well as in multiple other cancers. HER2‐targeted therapies improved progression‐free and overall survival in patients with HER2 + breast cancers. However, associated resistance mechanisms and toxicity highlight the need for new therapeutic approaches for these cancers. We recently established that, in normal cells, HER2 is stabilized in a catalytically repressed state by direct interaction with members of the ezrin/radixin/moesin (ERM) family. In HER2‐overexpressing tumors, the low expression of moesin contributes to the aberrant activation of HER2. Through a screen designed to find moesin‐mimicking compounds, we identified ebselen oxide. We show that ebselen oxide, and some derivatives, conferred an efficient allosteric inhibition of overexpressed HER2, as well as mutated and truncated oncogenic forms of HER2, which are resistant to current therapies. Ebselen oxide selectively inhibited anchorage‐dependent and ‐independent proliferation of HER2 + cancer cells and showed a significant benefit in combination with current anti‐HER2 therapeutic agents. Finally, ebselen oxide significantly blocked HER2 + breast tumor progression in vivo . Collectively, these data provide evidence that ebselen oxide is a newly identified allosteric inhibitor of HER2 to be considered for therapeutic intervention on HER2 + cancers." @default.
• W4324017926 created "2023-03-14" @default.
• W4324017926 creator A5009647602 @default.
• W4324017926 creator A5027380873 @default.
• W4324017926 creator A5038994193 @default.
• W4324017926 creator A5045337655 @default.
• W4324017926 date "2023-03-27" @default.
• W4324017926 modified "2023-10-12" @default.
• W4324017926 title "Ebselen oxide and derivatives are new allosteric <scp>HER2</scp> inhibitors for <scp>HER2</scp>‐positive cancers" @default.
• W4324017926 cites W2000522885 @default.
• W4324017926 cites W2008722821 @default.
• W4324017926 cites W2010061463 @default.
• W4324017926 cites W2023681515 @default.
• W4324017926 cites W2033764434 @default.
• W4324017926 cites W2040142253 @default.
• W4324017926 cites W2050046701 @default.
• W4324017926 cites W2071321282 @default.
• W4324017926 cites W2092897704 @default.
• W4324017926 cites W2099203391 @default.
• W4324017926 cites W2100794900 @default.
• W4324017926 cites W2123206362 @default.
• W4324017926 cites W2125868040 @default.
• W4324017926 cites W2142088831 @default.
• W4324017926 cites W2154077173 @default.
• W4324017926 cites W2168143678 @default.
• W4324017926 cites W2172265576 @default.
• W4324017926 cites W2293838703 @default.
• W4324017926 cites W2320829886 @default.
• W4324017926 cites W2403960089 @default.
• W4324017926 cites W2413643542 @default.
• W4324017926 cites W2516126644 @default.
• W4324017926 cites W2519946849 @default.
• W4324017926 cites W2732122454 @default.
• W4324017926 cites W2736124908 @default.
• W4324017926 cites W2770503852 @default.
• W4324017926 cites W2793996849 @default.
• W4324017926 cites W2795979587 @default.
• W4324017926 cites W2898416763 @default.
• W4324017926 cites W2949795865 @default.
• W4324017926 cites W2976352116 @default.
• W4324017926 cites W2977889895 @default.
• W4324017926 cites W3009593680 @default.
• W4324017926 cites W3021411361 @default.
• W4324017926 cites W3040877059 @default.
• W4324017926 cites W3084799711 @default.
• W4324017926 cites W3087356362 @default.
• W4324017926 cites W3093678905 @default.
• W4324017926 cites W3182742052 @default.
• W4324017926 cites W3195617271 @default.
• W4324017926 cites W3198517889 @default.
• W4324017926 cites W3215702511 @default.
• W4324017926 cites W54649336 @default.
• W4324017926 cites W56105314 @default.
• W4324017926 doi "https://doi.org/10.1002/1878-0261.13419" @default.
• W4324017926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36912768" @default.
• W4324017926 hasPublicationYear "2023" @default.
• W4324017926 type Work @default.
• W4324017926 citedByCount "0" @default.
• W4324017926 crossrefType "journal-article" @default.
• W4324017926 hasAuthorship W4324017926A5009647602 @default.
• W4324017926 hasAuthorship W4324017926A5027380873 @default.
• W4324017926 hasAuthorship W4324017926A5038994193 @default.
• W4324017926 hasAuthorship W4324017926A5045337655 @default.
• W4324017926 hasBestOaLocation W43240179261 @default.
• W4324017926 hasConcept C101544691 @default.
• W4324017926 hasConcept C104317684 @default.
• W4324017926 hasConcept C121608353 @default.
• W4324017926 hasConcept C126322002 @default.
• W4324017926 hasConcept C127561419 @default.
• W4324017926 hasConcept C142669718 @default.
• W4324017926 hasConcept C1491633281 @default.
• W4324017926 hasConcept C166342909 @default.
• W4324017926 hasConcept C170493617 @default.
• W4324017926 hasConcept C181199279 @default.
• W4324017926 hasConcept C185592680 @default.
• W4324017926 hasConcept C196509110 @default.
• W4324017926 hasConcept C2776292417 @default.
• W4324017926 hasConcept C2778760513 @default.
• W4324017926 hasConcept C2779138974 @default.
• W4324017926 hasConcept C2780246058 @default.
• W4324017926 hasConcept C502942594 @default.
• W4324017926 hasConcept C538909803 @default.
• W4324017926 hasConcept C55493867 @default.
• W4324017926 hasConcept C71924100 @default.
• W4324017926 hasConcept C98274493 @default.
• W4324017926 hasConceptScore W4324017926C101544691 @default.
• W4324017926 hasConceptScore W4324017926C104317684 @default.
• W4324017926 hasConceptScore W4324017926C121608353 @default.
• W4324017926 hasConceptScore W4324017926C126322002 @default.
• W4324017926 hasConceptScore W4324017926C127561419 @default.
• W4324017926 hasConceptScore W4324017926C142669718 @default.
• W4324017926 hasConceptScore W4324017926C1491633281 @default.
• W4324017926 hasConceptScore W4324017926C166342909 @default.
• W4324017926 hasConceptScore W4324017926C170493617 @default.
• W4324017926 hasConceptScore W4324017926C181199279 @default.
• W4324017926 hasConceptScore W4324017926C185592680 @default.
• W4324017926 hasConceptScore W4324017926C196509110 @default.
• W4324017926 hasConceptScore W4324017926C2776292417 @default.
• W4324017926 hasConceptScore W4324017926C2778760513 @default.
• W4324017926 hasConceptScore W4324017926C2779138974 @default.

• next