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• W4324018025 abstract "In recent years, better knowledge of the pathophysiology of inflammatory bowel diseases (IBD) has led to a relevant expansion of the therapeutic arsenal for these conditions. Janus kinase (JAK) inhibitors are a family of small molecules that block one or more of the intracellular tyrosine kinases, including JAK-1, JAK-2, JAK-3 and TYK-2. Tofacitinib, a non-selective small molecule JAK inhibitor, and upadacitinib and filgotinib, which are selective JAK-1 inhibitors, have been approved by the US Food and Drug Administration (FDA) for moderate-to-severe active ulcerative colitis. Compared to biological drugs, JAK inhibitors have a short half-life, rapid onset of action, and no immunogenicity. Both clinical trials and real-world evidence support the use of JAK inhibitors in the treatment of IBD. However, these therapies have been linked with multiple adverse events (AEs) including infection, hypercholesterolemia, venous thromboembolism, major adverse cardiovascular events, and malignancy. While early studies recognized several potential AEs, post-marketing trials have shown that tofacitinib may increase the risk of thromboembolic diseases and major cardiovascular events. The latter are seen in patients aged 50 years or older with cardiovascular risk factors. Hence, the benefits of treatment and risk stratification need to be considered when positioning tofacitinib. Novel JAK inhibitors with a more selective effect on JAK-1 have proven to be effective in both Crohn's disease and ulcerative colitis, offering a potentially safer and efficacious therapeutic option to patients, including those with previous non-response to other therapies such as biologics. Nevertheless, long-term effectiveness and safety data are required." @default.
• W4324018025 created "2023-03-14" @default.
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• W4324018025 date "2023-03-01" @default.
• W4324018025 modified "2023-10-09" @default.
• W4324018025 title "Safety of Janus Kinase Inhibitors in Inflammatory Bowel Diseases" @default.
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• W4324018025 cites W2072640801 @default.
• W4324018025 cites W2105159981 @default.
• W4324018025 cites W2122950669 @default.
• W4324018025 cites W2153414586 @default.
• W4324018025 cites W2168645087 @default.
• W4324018025 cites W2554182402 @default.
• W4324018025 cites W2561041192 @default.
• W4324018025 cites W2583548739 @default.
• W4324018025 cites W2584337339 @default.
• W4324018025 cites W2587875644 @default.
• W4324018025 cites W2593085926 @default.
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• W4324018025 cites W2759956418 @default.
• W4324018025 cites W2766717228 @default.
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• W4324018025 cites W2807009918 @default.
• W4324018025 cites W2809380200 @default.
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• W4324018025 cites W2910459213 @default.
• W4324018025 cites W2914619421 @default.
• W4324018025 cites W2944352931 @default.
• W4324018025 cites W2946759634 @default.
• W4324018025 cites W2976362764 @default.
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• W4324018025 cites W3047229059 @default.
• W4324018025 cites W3048071747 @default.
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• W4324018025 cites W3092880928 @default.
• W4324018025 cites W3094105410 @default.
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• W4324018025 cites W3108065059 @default.
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• W4324018025 cites W3164041179 @default.
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• W4324018025 cites W3204310354 @default.
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• W4324018025 cites W4210529991 @default.
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• W4324018025 doi "https://doi.org/10.1007/s40265-023-01840-5" @default.
• W4324018025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36913180" @default.
• W4324018025 hasPublicationYear "2023" @default.
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