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- W4324018393 abstract "Osteoporosis (OP) is the most prevalent metabolic bone disease, characterized by the low bone mass and microarchitectural deterioration of bone tissue. Glucocorticoid (GC) clinically acts as one of the anti-inflammatory, immune-modulating, and therapeutic drugs, whereas the long-term use of GC may cause rapid bone resorption, followed by prolonged and profound suppression of bone formation, resulting in the GC-induced OP (GIOP). GIOP ranks the first among secondary OP and is a pivotal risk for fracture, as well as high disability rate and mortality, at both societal and personal levels, vital costs. Gut microbiota (GM), known as the second gene pool of human body, is highly correlated with maintaining the bone mass and bone quality, and the relation between GM and bone metabolism has gradually become a research hotspot. Herein, combined with recent studies and based on the cross-linking relationship between GM and OP, this review is aimed to discuss the potential mechanisms of GM and its metabolites on the OP, as well as the moderating effects of GC on GM, thereby providing an emerging thought for prevention and treatment of GIOP." @default.
- W4324018393 created "2023-03-14" @default.
- W4324018393 creator A5000712189 @default.
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- W4324018393 creator A5020816113 @default.
- W4324018393 creator A5027914638 @default.
- W4324018393 creator A5039052371 @default.
- W4324018393 creator A5085506096 @default.
- W4324018393 date "2023-03-01" @default.
- W4324018393 modified "2023-10-10" @default.
- W4324018393 title "Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis" @default.
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