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• W4324026432 abstract "Abstract Background Screening hub genes to provide new basis for diagnosis and treatment of patients with colorectal cancer (CRC). Methods Potential biomarkers for human CRC were identified and validated by bioinformatic analysis based on Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets, and the correlations between the biomarkers and tumor immune cell infiltration were analyzed by Tumor Immune Estimation Resource (TIMER) project. Subsequently, upstream regulatory ncRNA of the potential biomarkers was identified to construct a novel competing endogenous RNA (ceRNA) network in CRC, and functional annotation of the ceRNA network was performed by Gene Set Enrichment Analysis (GSEA). Results A total of 950 DEGs were screened, including 539 downregulated genes and 411 upregulated genes. GO analysis showed that the DEGs were mainly involved in cell adhesion, inflammatory response, signal transduction and protein binding. KEGG pathway analysis revealed that the DEGs were mainly enriched in TNF signaling pathway, PI3K-Akt signaling pathway, Wnt-signaling pathway, Metabolic pathways, PPAR signaling pathway, and Pathways in cancer. The PPI network was constructed with 827 nodes and 4568 edges. 4 key modules and 10 hub genes were selected by Cytoscape software. The survival analysis revealed that high POSTN expression and low IL1B expression were related to worse survival in patients with CRC. In addition, the expression of IL1B and POSTN had significant correlation with multiple tumor immune cells and the expression of immune checkpoints. Finally, NR2F2-AS1/miR-425-5p and AC016747.1/miR-576-5p were identified as upstream regulatory ncRNAs that could potentially bind POSTN in human CRC. Conclusion NR2F2-AS1/miR-425-5p and AC016747.1/miR-576-5p may regulate the progression of CRC by targeting POSTN." @default.
• W4324026432 created "2023-03-14" @default.
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• W4324026432 date "2023-03-13" @default.
• W4324026432 modified "2023-09-26" @default.
• W4324026432 title "ncRNAs-mediated high expression of POSTN correlates with poor prognosis and tumor immune infiltration of colorectal cancer" @default.
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• W4324026432 doi "https://doi.org/10.21203/rs.3.rs-2626697/v1" @default.
• W4324026432 hasPublicationYear "2023" @default.
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