Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324026889> ?p ?o ?g. }
- W4324026889 abstract "ABSTRACT Aurora Kinase A (AURKA) is an oncogenic kinase with major roles in mitosis, but also exerts cell cycle- and kinase-independent functions linked to cancer. Therefore control of its expression, as well as its activity, is crucial. A short and a long 3’UTR isoform exist for AURKA mRNA, resulting from alternative polyadenylation (APA). We initially observed that in Triple Negative Breast Cancer, where AURKA is typically overexpressed, the short isoform is predominant and this correlates with faster relapse times of patients. The short isoform is characterized by higher translational efficiency since translation and decay rate of the long isoform are targeted by hsa-let-7a tumor-suppressor miRNA. Additionally, hsa-let-7a regulates the cell cycle periodicity of translation of the long isoform, whereas the short isoform is translated highly and constantly throughout interphase. Finally, disrupted production of the long isoform led to an increase in proliferation and migration rates of cells. In sum, we uncovered a new mechanism dependent on the cooperation between APA and miRNA targeting likely to be a route of oncogenic activation of human AURKA." @default.
- W4324026889 created "2023-03-14" @default.
- W4324026889 creator A5004498216 @default.
- W4324026889 creator A5060569121 @default.
- W4324026889 creator A5062955549 @default.
- W4324026889 creator A5067155424 @default.
- W4324026889 creator A5076216631 @default.
- W4324026889 date "2023-03-13" @default.
- W4324026889 modified "2023-09-30" @default.
- W4324026889 title "Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A" @default.
- W4324026889 cites W1516095885 @default.
- W4324026889 cites W1657157395 @default.
- W4324026889 cites W1744683414 @default.
- W4324026889 cites W1912417670 @default.
- W4324026889 cites W1964727443 @default.
- W4324026889 cites W2004442803 @default.
- W4324026889 cites W2007227595 @default.
- W4324026889 cites W2018486347 @default.
- W4324026889 cites W2019267973 @default.
- W4324026889 cites W2023822776 @default.
- W4324026889 cites W2027266940 @default.
- W4324026889 cites W2036065307 @default.
- W4324026889 cites W2039210066 @default.
- W4324026889 cites W2065782380 @default.
- W4324026889 cites W2069571430 @default.
- W4324026889 cites W2072133788 @default.
- W4324026889 cites W2074114726 @default.
- W4324026889 cites W2084001490 @default.
- W4324026889 cites W2091448229 @default.
- W4324026889 cites W2094340226 @default.
- W4324026889 cites W2099915768 @default.
- W4324026889 cites W2105004481 @default.
- W4324026889 cites W2109712459 @default.
- W4324026889 cites W2115734610 @default.
- W4324026889 cites W2118834857 @default.
- W4324026889 cites W2119875500 @default.
- W4324026889 cites W2123285201 @default.
- W4324026889 cites W2132194692 @default.
- W4324026889 cites W2137753785 @default.
- W4324026889 cites W2139795964 @default.
- W4324026889 cites W2143525699 @default.
- W4324026889 cites W2161093157 @default.
- W4324026889 cites W2161956519 @default.
- W4324026889 cites W2162694012 @default.
- W4324026889 cites W2167279371 @default.
- W4324026889 cites W2168420558 @default.
- W4324026889 cites W2169515696 @default.
- W4324026889 cites W2175574562 @default.
- W4324026889 cites W2235443461 @default.
- W4324026889 cites W2260331558 @default.
- W4324026889 cites W2288271511 @default.
- W4324026889 cites W2427010553 @default.
- W4324026889 cites W2461965332 @default.
- W4324026889 cites W2530453716 @default.
- W4324026889 cites W2548429415 @default.
- W4324026889 cites W2549976854 @default.
- W4324026889 cites W2765241807 @default.
- W4324026889 cites W2766614445 @default.
- W4324026889 cites W2773068569 @default.
- W4324026889 cites W2791883166 @default.
- W4324026889 cites W2804265440 @default.
- W4324026889 cites W2804498504 @default.
- W4324026889 cites W2807169763 @default.
- W4324026889 cites W2808584889 @default.
- W4324026889 cites W2888423279 @default.
- W4324026889 cites W2940950898 @default.
- W4324026889 cites W2953929685 @default.
- W4324026889 cites W2970358232 @default.
- W4324026889 cites W2972457898 @default.
- W4324026889 cites W2973843140 @default.
- W4324026889 cites W2976224211 @default.
- W4324026889 cites W2998874790 @default.
- W4324026889 cites W3019119825 @default.
- W4324026889 cites W3019545037 @default.
- W4324026889 cites W3021650619 @default.
- W4324026889 cites W3081608318 @default.
- W4324026889 cites W3087441585 @default.
- W4324026889 cites W3098189283 @default.
- W4324026889 cites W3107743495 @default.
- W4324026889 cites W3123995258 @default.
- W4324026889 cites W3130489784 @default.
- W4324026889 cites W3135463285 @default.
- W4324026889 cites W3161688917 @default.
- W4324026889 cites W4220937155 @default.
- W4324026889 cites W4283325681 @default.
- W4324026889 cites W4284675316 @default.
- W4324026889 cites W4294841906 @default.
- W4324026889 cites W4308458887 @default.
- W4324026889 doi "https://doi.org/10.1101/2023.03.13.532331" @default.
- W4324026889 hasPublicationYear "2023" @default.
- W4324026889 type Work @default.
- W4324026889 citedByCount "0" @default.
- W4324026889 crossrefType "posted-content" @default.
- W4324026889 hasAuthorship W4324026889A5004498216 @default.
- W4324026889 hasAuthorship W4324026889A5060569121 @default.
- W4324026889 hasAuthorship W4324026889A5062955549 @default.
- W4324026889 hasAuthorship W4324026889A5067155424 @default.
- W4324026889 hasAuthorship W4324026889A5076216631 @default.
- W4324026889 hasBestOaLocation W43240268891 @default.
- W4324026889 hasConcept C104317684 @default.