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• W4324028828 abstract "Abstract The COVID-19 pandemic has illustrated the potential for monoclonal antibody therapeutics as prophylactic and therapeutic agents against pandemic viruses. No such therapeutics currently exist for other human coronaviruses. NL63 is a human alphacoronavirus that typically causes the common cold and uses the same receptor, ACE2, as the highly pathogenic SARS-CoV and SARS-CoV-2 pandemic viruses. In a cohort of healthy adults, we characterised humoral responses against the NL63 spike protein. While NL63 spike and receptor binding domain-specific binding antibodies and neutralisation activity could be detected in plasma of all subjects, memory B cells against NL63 spike were variable and relatively low in frequency compared to that against SARS-CoV-2 spike. From these donors, we isolated a panel of antibodies against NL63 spike and characterised their neutralising potential. We identified potent neutralising antibodies that recognised the receptor binding domain (RBD) and other non-RBD epitopes within spike." @default.
• W4324028828 created "2023-03-14" @default.
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• W4324028828 date "2023-03-13" @default.
• W4324028828 modified "2023-10-16" @default.
• W4324028828 title "Monoclonal antibodies against human coronavirus NL63 spike" @default.
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• W4324028828 doi "https://doi.org/10.1101/2023.03.12.532265" @default.
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