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- W4324045957 abstract "Abstract Purpose : Thyroid dysfunction in patients with Klinefelter syndrome (KS) remains an unresolved issue. Although low free thyroxine (FT4) levels within the normal range and normal thyroid stimulating hormone (TSH) levels have been reported, there is currently no data on nodular thyroid disease in this population. This study aims to evaluate the results of thyroid ultrasound (US) examinations in KS patients compared with healthy controls. Methods : A cohort of 122 KS and 85 age-matched healthy male controls underwent thyroid US screening and thyroid hormone analysis. According to US risk-stratification systems, nodules ≥1 cm were examined by fine needle aspiration (FNA). Results : Thyroid US detected nodular thyroid disease in 31% of KS compared to 1.3% of controls. No statistical differences in the maximum diameter of the largest nodules and in moderate and highly suspicious nodules were found between patients and the control group. Six nodules underwent FNA and were confirmed as cytologically benign. In line with published data, FT4 levels were found significantly near the lower limit of the normal range compared to controls, with no differences in TSH values between the two groups. Hashimoto’s thyroiditis was diagnosed in 9% of patients. Conclusions : We observed a significantly higher prevalence of nodular thyroid disease in KS compared to the control group, but no increased risk of thyroid cancer. The increase in nodular thyroid disease is likely linked to low levels of FT4, inappropriate TSH secretion, and/or genetic instability. We suggest including a complete thyroid evaluation in the workup of KS." @default.
- W4324045957 created "2023-03-14" @default.
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- W4324045957 date "2023-03-13" @default.
- W4324045957 modified "2023-10-18" @default.
- W4324045957 title "Nodular thyroid disease and low FT4 levels in Klinefelter syndrome: an extension of the classical phenotype" @default.
- W4324045957 doi "https://doi.org/10.21203/rs.3.rs-2648344/v1" @default.
- W4324045957 hasPublicationYear "2023" @default.
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