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- W4324046054 abstract "Abstract Background This protocol describes the design of a multicenter randomized controlled trial of robot-assisted stereotactic lesioning versus epileptogenic foci resection. Typical causes of focal epilepsy include hippocampal sclerosis and focal cortical dysplasia. These patients usually present with drug resistance and require surgical treatment. Although epileptogenic foci resection is still the most commonly used treatment for such focal epilepsy, there is increasing evidence that epileptogenic focus resection may lead to neurological impairment. The treatment of epilepsy with robot- assisted stereotactic lesioning mainly includes two new minimally invasive surgical methods: radiofrequency thermocoagulation (RF-TC) and laser interstitial thermal therapy (LITT). Seizure-free is less likely to be achieved by these two procedures, but neurologic preservation is better. In this study, we aimed to compare the safety and efficacy of RF-TC, LITT, and epileptogenic foci resection for focal drug-resistant epilepsy. Methods This is a multicenter, three-arm, randomized controlled clinical trial. The study will include patients older than 3 years of age with epilepsy who have had medically refractory seizures for at least 2 years and are eligible for surgical treatment with an epileptogenic focus as determined by multidisciplinary evaluation prior to randomization. The primary outcome measure is seizure outcome (quantified by seizure remission rate) at 3-month, 6-month, and 1-year follow-up after treatment. Postoperative neurologic impairment, spectrum distribution change of video electroencephalogram, quality of life, and medical costs are also assessed as secondary outcomes. Trial registration URL: https://chictr.org.cn. ChiCTR2200060974. Registered on June 14, 2022. The status of the trial is recruiting and the estimated study completion date is December 31, 2024." @default.
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- W4324046054 date "2023-03-13" @default.
- W4324046054 modified "2023-09-23" @default.
- W4324046054 title "Protocol of a prospective multicenter randomized controlled trial of robot-assisted stereotatic lesioning in the treatment of focal drug-resistant epilepsy" @default.
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- W4324046054 doi "https://doi.org/10.21203/rs.3.rs-2523764/v1" @default.
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