FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324046556> ?p ?o ?g. }

• W4324046556 endingPage "186" @default.
• W4324046556 startingPage "171" @default.
• W4324046556 abstract "Multidrug resistance of pathogenic microflora is a serious threat to the modern community looking for new approaches to treating superinfections. In this sense, antimicrobial photodynamic therapy (aPDT) is an effective and safe technique considered to be a promising alternative or an important supplement to the traditional clinically applied methods for inactivating antibiotic resistant pathogens. Macroheterocyclic photosensitizers (PS) of three generations are proposed for clinical practice. They are known as the key compounds for PDT able to be localized selectively in microbial cells and to be activated with the red light producing toxic reactive oxygen species (ROS). However, these neutral and anionic PSs possess low affinity towards the outer lipopolysaccharide membrane of Gram-negative bacteria and, consequently, poor ability to kill these pathogens under irradiation. In contrast, cationic PSs containing one or more charged groups, especially those bound to an appropriate carrier, provide efficient inactivation of microorganisms. In this paper, we focus on the study of photophysics, aggregation and photoinduced antimicrobial activity of the water-soluble derivative of deuteroporphyrin-IX, a blood group porphyrin, bearing two cationic trialkylammonium fragments. This potential photosensitizing agent is found to generate singlet oxygen in a non-polar environment and forms stable nano-sized molecular complexes with passive non-ionic carrier Tween 80, localizing in an aqueous surfactant solution as a non-aggregated form in the surface micellar layer. Two different modes of PS/Tween 80 binding characterized by their own stability constants and interaction stoichiometry are observed. Microbiological experiments clearly demonstrate that the increased permeability of the outer bacterial membrane caused by the application of the intramicellar form of the photosensitizer or addition of some potentiation agents leads to pronounced light phototoxicity of the pigment against antibiotic-resistant nosocomial strains of Gram-negative bacterial pathogens." @default.
• W4324046556 created "2023-03-14" @default.
• W4324046556 creator A5009530186 @default.
• W4324046556 creator A5031264423 @default.
• W4324046556 creator A5052997477 @default.
• W4324046556 creator A5054083556 @default.
• W4324046556 creator A5076477206 @default.
• W4324046556 creator A5086714943 @default.
• W4324046556 date "2023-03-11" @default.
• W4324046556 modified "2023-09-30" @default.
• W4324046556 title "Water-Soluble Dicationic Deuteroporphyrin Derivative for Antimicrobial PDT: Singlet Oxygen Generation, Passive Carrier Interaction and Nosocomial Bacterial Strains Photoinactivation" @default.
• W4324046556 cites W1909548258 @default.
• W4324046556 cites W1919412794 @default.
• W4324046556 cites W1966979808 @default.
• W4324046556 cites W1993901159 @default.
• W4324046556 cites W2013290148 @default.
• W4324046556 cites W2031021428 @default.
• W4324046556 cites W2082651961 @default.
• W4324046556 cites W2084574464 @default.
• W4324046556 cites W2097755819 @default.
• W4324046556 cites W2114012485 @default.
• W4324046556 cites W2157812356 @default.
• W4324046556 cites W2184984169 @default.
• W4324046556 cites W2251365842 @default.
• W4324046556 cites W2285739689 @default.
• W4324046556 cites W2320574135 @default.
• W4324046556 cites W2333021620 @default.
• W4324046556 cites W2475022942 @default.
• W4324046556 cites W2488927006 @default.
• W4324046556 cites W2530288914 @default.
• W4324046556 cites W2555127056 @default.
• W4324046556 cites W2590947287 @default.
• W4324046556 cites W2603975673 @default.
• W4324046556 cites W2613064815 @default.
• W4324046556 cites W2743219737 @default.
• W4324046556 cites W2766958270 @default.
• W4324046556 cites W2767064005 @default.
• W4324046556 cites W2803339107 @default.
• W4324046556 cites W2806707527 @default.
• W4324046556 cites W2900581380 @default.
• W4324046556 cites W2907502823 @default.
• W4324046556 cites W2923735535 @default.
• W4324046556 cites W2943540825 @default.
• W4324046556 cites W2944477741 @default.
• W4324046556 cites W2945303331 @default.
• W4324046556 cites W2954110626 @default.
• W4324046556 cites W2969159587 @default.
• W4324046556 cites W2978892662 @default.
• W4324046556 cites W2980693298 @default.
• W4324046556 cites W3090870575 @default.
• W4324046556 cites W3126314624 @default.
• W4324046556 cites W3166118228 @default.
• W4324046556 cites W3198715393 @default.
• W4324046556 cites W3210271032 @default.
• W4324046556 cites W4205507384 @default.
• W4324046556 cites W4214501104 @default.
• W4324046556 cites W4229442229 @default.
• W4324046556 cites W4236150029 @default.
• W4324046556 cites W4253366065 @default.
• W4324046556 cites W4256156736 @default.
• W4324046556 cites W4285531260 @default.
• W4324046556 cites W4288051059 @default.
• W4324046556 cites W4291130994 @default.
• W4324046556 cites W4313245489 @default.
• W4324046556 cites W4313260010 @default.
• W4324046556 cites W4313565961 @default.
• W4324046556 doi "https://doi.org/10.3390/photochem3010011" @default.
• W4324046556 hasPublicationYear "2023" @default.
• W4324046556 type Work @default.
• W4324046556 citedByCount "2" @default.
• W4324046556 countsByYear W43240465562023 @default.
• W4324046556 crossrefType "journal-article" @default.
• W4324046556 hasAuthorship W4324046556A5009530186 @default.
• W4324046556 hasAuthorship W4324046556A5031264423 @default.
• W4324046556 hasAuthorship W4324046556A5052997477 @default.
• W4324046556 hasAuthorship W4324046556A5054083556 @default.
• W4324046556 hasAuthorship W4324046556A5076477206 @default.
• W4324046556 hasAuthorship W4324046556A5086714943 @default.
• W4324046556 hasBestOaLocation W43240465561 @default.
• W4324046556 hasConcept C12554922 @default.
• W4324046556 hasConcept C178790620 @default.
• W4324046556 hasConcept C183882617 @default.
• W4324046556 hasConcept C185592680 @default.
• W4324046556 hasConcept C21951064 @default.
• W4324046556 hasConcept C2777516457 @default.
• W4324046556 hasConcept C2779480358 @default.
• W4324046556 hasConcept C2781323092 @default.
• W4324046556 hasConcept C2781469039 @default.
• W4324046556 hasConcept C2992270614 @default.
• W4324046556 hasConcept C41625074 @default.
• W4324046556 hasConcept C48349386 @default.
• W4324046556 hasConcept C4937899 @default.
• W4324046556 hasConcept C540031477 @default.
• W4324046556 hasConcept C55493867 @default.
• W4324046556 hasConcept C75473681 @default.
• W4324046556 hasConcept C86803240 @default.
• W4324046556 hasConceptScore W4324046556C12554922 @default.
• W4324046556 hasConceptScore W4324046556C178790620 @default.

• next