FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324056758> ?p ?o ?g. }

• W4324056758 endingPage "880" @default.
• W4324056758 startingPage "880" @default.
• W4324056758 abstract "In the brain, vesicular zinc, which refers to a subset of zinc that is sequestered into synaptic vesicles by zinc transporter 3 (ZnT3), has extensive effects on neuronal signalling and modulation. Vesicular zinc-focused research has mainly been directed to its role in the hippocampus, particularly in adult neurogenesis. However, whether vesicular zinc is involved in modulating neurogenesis during the early postnatal period has been less studied. As a first step to understanding this, we used ZnT3 knockout (KO) mice, which lack ZnT3 and, thus, vesicular zinc, to evaluate cell proliferation at three different age points spanning postnatal development (P6, P14, and P28). The survival and the neuronal phenotype of these cells was also assessed in adulthood. We found that male ZnT3 KO mice exhibited lower rates of cell proliferation at P14, but a greater number of these cells survived to adulthood. Additionally, significantly more cells labelled on P6 survived to adulthood in male and female ZnT3 KO mice. We also found sex-dependent differences, whereby male mice showed higher levels of cell proliferation at P28, as well as higher levels of cell survival for P14-labelled cells, compared to female mice. However, female mice showed greater percentages of neuronal differentiation for P14-labelled cells. Finally, we found significant effects of age of BrdU injections on cell proliferation, survival, and neuronal differentiation. Collectively, our results suggest that the loss of vesicular zinc affects normal proliferation and survival of cells born at different age points during postnatal development and highlight prominent sex- and age-dependent differences. Our findings provide the foundation for future studies to further probe the role of vesicular zinc in the modulation of developmental neurogenesis." @default.
• W4324056758 created "2023-03-14" @default.
• W4324056758 creator A5030646265 @default.
• W4324056758 creator A5033114548 @default.
• W4324056758 creator A5068167531 @default.
• W4324056758 creator A5073935866 @default.
• W4324056758 date "2023-03-11" @default.
• W4324056758 modified "2023-10-05" @default.
• W4324056758 title "Vesicular Zinc Modulates Cell Proliferation and Survival in the Developing Hippocampus" @default.
• W4324056758 cites W1484682139 @default.
• W4324056758 cites W1533389761 @default.
• W4324056758 cites W1545362848 @default.
• W4324056758 cites W1629059403 @default.
• W4324056758 cites W1828269311 @default.
• W4324056758 cites W1956314911 @default.
• W4324056758 cites W1959090475 @default.
• W4324056758 cites W1963491971 @default.
• W4324056758 cites W1965650813 @default.
• W4324056758 cites W1967523826 @default.
• W4324056758 cites W1968840425 @default.
• W4324056758 cites W1970000810 @default.
• W4324056758 cites W1970169677 @default.
• W4324056758 cites W1973607985 @default.
• W4324056758 cites W1980499453 @default.
• W4324056758 cites W1982600497 @default.
• W4324056758 cites W1983019472 @default.
• W4324056758 cites W1990122650 @default.
• W4324056758 cites W1993674163 @default.
• W4324056758 cites W1995075470 @default.
• W4324056758 cites W1995188451 @default.
• W4324056758 cites W1998643162 @default.
• W4324056758 cites W2000095194 @default.
• W4324056758 cites W2002197532 @default.
• W4324056758 cites W2005353896 @default.
• W4324056758 cites W2006624547 @default.
• W4324056758 cites W2007242343 @default.
• W4324056758 cites W2008963984 @default.
• W4324056758 cites W2011792940 @default.
• W4324056758 cites W2012944967 @default.
• W4324056758 cites W2016489565 @default.
• W4324056758 cites W2024333143 @default.
• W4324056758 cites W2034917512 @default.
• W4324056758 cites W2035089473 @default.
• W4324056758 cites W2035158911 @default.
• W4324056758 cites W2035494313 @default.
• W4324056758 cites W2051523207 @default.
• W4324056758 cites W2062765507 @default.
• W4324056758 cites W2070083014 @default.
• W4324056758 cites W2070087327 @default.
• W4324056758 cites W2072439402 @default.
• W4324056758 cites W2072476822 @default.
• W4324056758 cites W2074313017 @default.
• W4324056758 cites W2077122729 @default.
• W4324056758 cites W2078297328 @default.
• W4324056758 cites W2079156156 @default.
• W4324056758 cites W2080003243 @default.
• W4324056758 cites W2083194463 @default.
• W4324056758 cites W2087983133 @default.
• W4324056758 cites W2087995208 @default.
• W4324056758 cites W2090075451 @default.
• W4324056758 cites W2105382539 @default.
• W4324056758 cites W2108272094 @default.
• W4324056758 cites W2110468044 @default.
• W4324056758 cites W2111062737 @default.
• W4324056758 cites W2124960654 @default.
• W4324056758 cites W2124988147 @default.
• W4324056758 cites W2139450672 @default.
• W4324056758 cites W2144397723 @default.
• W4324056758 cites W2145235967 @default.
• W4324056758 cites W2146316688 @default.
• W4324056758 cites W2154311997 @default.
• W4324056758 cites W2154473726 @default.
• W4324056758 cites W2154908600 @default.
• W4324056758 cites W2159202946 @default.
• W4324056758 cites W2162184782 @default.
• W4324056758 cites W2166384415 @default.
• W4324056758 cites W2169063473 @default.
• W4324056758 cites W2169069314 @default.
• W4324056758 cites W2169507217 @default.
• W4324056758 cites W2292674289 @default.
• W4324056758 cites W2465071028 @default.
• W4324056758 cites W2563978280 @default.
• W4324056758 cites W2626046544 @default.
• W4324056758 cites W2801840975 @default.
• W4324056758 cites W2809176836 @default.
• W4324056758 cites W2892345931 @default.
• W4324056758 cites W2911403751 @default.
• W4324056758 cites W2918648567 @default.
• W4324056758 cites W2940132640 @default.
• W4324056758 cites W2948074239 @default.
• W4324056758 cites W2949587141 @default.
• W4324056758 cites W2964674361 @default.
• W4324056758 cites W2969577067 @default.
• W4324056758 cites W2979005092 @default.
• W4324056758 cites W2995220262 @default.
• W4324056758 cites W3012555676 @default.
• W4324056758 cites W3019182886 @default.
• W4324056758 cites W3030907271 @default.

• next