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- W4324056768 abstract "Zinc is highly concentrated in synaptic vesicles throughout the mammalian telencephalon and, in particular, the hippocampal dentate gyrus. A role for zinc in modulating synaptic plasticity has been inferred, but whether zinc has a particular role in experience-dependent plasticity has yet to be determined. The aim of the current study was to determine whether vesicular zinc is important for modulating adult hippocampal neurogenesis in an experience-dependent manner and, consequently, hippocampal-dependent behaviour. We assessed the role of vesicular zinc in modulating hippocampal neurogenesis and behaviour by comparing ZnT3 knockout (KO) mice, which lack vesicular zinc, to wild-type (WT) littermates exposed to either standard housing conditions (SH) or an enriched environment (EE). We found that vesicular zinc is necessary for a cascade of changes in hippocampal plasticity following EE, such as increases in hippocampal neurogenesis and elevations in mature brain-derived neurotrophic factor (mBDNF), but was otherwise dispensable under SH conditions. Using the Spatial Object Recognition task and the Morris Water task we show that, unlike WT mice, ZnT3 KO mice showed no improvements in spatial memory following EE. These experiments demonstrate that vesicular zinc is essential for the enhancement of adult hippocampal neurogenesis and behaviour following enrichment, supporting a role for zincergic neurons in contributing to experience-dependent plasticity in the hippocampus." @default.
- W4324056768 created "2023-03-14" @default.
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- W4324056768 date "2023-03-13" @default.
- W4324056768 modified "2023-10-01" @default.
- W4324056768 title "Environmental Enrichment Engages Vesicular Zinc Signaling to Enhance Hippocampal Neurogenesis" @default.
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- W4324056768 doi "https://doi.org/10.3390/cells12060883" @default.
- W4324056768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36980224" @default.
- W4324056768 hasPublicationYear "2023" @default.
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