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- W4324058082 endingPage "5369" @default.
- W4324058082 startingPage "5369" @default.
- W4324058082 abstract "The metabolic syndrome (MS) is a cluster of risk factors, such as central obesity, hyperglycemia, dyslipidemia, and arterial hypertension, which increase the probability of causing premature mortality. The consumption of high-fat diets (HFD), normally referred to high-saturated fat diets, is a major driver of the rising incidence of MS. In fact, the altered interplay between HFD, microbiome, and the intestinal barrier is being considered as a possible origin of MS. Consumption of proanthocyanidins (PAs) has a beneficial effect against the metabolic disturbances in MS. However, there are no conclusive results in the literature about the efficacy of PAs in improving MS. This review allows a comprehensive validation of the diverse effects of the PAs on the intestinal dysfunction in HFD-induced MS, differentiating between preventive and therapeutic actions. Special emphasis is placed on the impact of PAs on the gut microbiota, providing a system to facilitate comparison between the studies. PAs can modulate the microbiome toward a healthy profile and strength barrier integrity. Nevertheless, to date, published clinical trials to verify preclinical findings are scarce. Finally, the preventive consumption of PAs in MS-associated dysbiosis and intestinal dysfunction induced by HFD seems more successful than the treatment strategy." @default.
- W4324058082 created "2023-03-14" @default.
- W4324058082 creator A5006437937 @default.
- W4324058082 creator A5042280935 @default.
- W4324058082 creator A5055456881 @default.
- W4324058082 creator A5057168448 @default.
- W4324058082 creator A5062920968 @default.
- W4324058082 creator A5067109618 @default.
- W4324058082 creator A5067931543 @default.
- W4324058082 creator A5076772878 @default.
- W4324058082 creator A5088081550 @default.
- W4324058082 date "2023-03-10" @default.
- W4324058082 modified "2023-10-18" @default.
- W4324058082 title "Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome" @default.
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