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- W4324098523 abstract "Abstract Psychopathological research is moving from a specific approach towards transdiagnosis through the analysis of processes that appear transversally to multiple pathologies. A phenomenon disrupted in several disorders is prepulse inhibition (PPI) of the startle response, in which startle to an intense sensory stimulus, or pulse, is reduced if a weak stimulus, or prepulse, is previously presented. The present systematic review analyzed the role of PPI deficit as a possible transdiagnostic process for three main groups of neuropsychiatric disorders: 1) trauma-, stress-, and anxiety-related disorders 2) mood-related disorders, and 3) neurocognitive disorders. We used Web of Science, Pubmed and PsycInfo databases to search for experimental case-control articles that were analyzed both bibliometrically and based on their potential risk of bias. A total of 41 studies were included in this systematic review. The results showed a general PPI deficit in the three diagnostic groups mentioned, with associated deficits in the dopaminergic neurotransmission system, several areas implied such as the medial prefrontal cortex or the amygdala, and related variables such as cognitive deficits and anxiety symptoms. It can be concluded that the PPI deficit is a transdiagnostic process across most of the neuropsychiatric disorders examined, and it is a relevant measure in translational research for the early detection and intervention of such disorders. Protocol submitted prospectively to PROSPERO 04/30/2022 (CRD42022322031)." @default.
- W4324098523 created "2023-03-14" @default.
- W4324098523 creator A5045776943 @default.
- W4324098523 creator A5061923741 @default.
- W4324098523 date "2023-03-13" @default.
- W4324098523 modified "2023-10-16" @default.
- W4324098523 title "Prepulse Inhibition Deficit as a Transdiagnostic Process in Neuropsychiatric Disorders: A Systematic Review" @default.
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