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- W4324101808 abstract "Genomic DNA is a crowded track where motor proteins frequently collide. It remains underexplored whether these collisions carry physiological function. In this work, we develop a single-molecule assay to visualize the trafficking of individual E. coli RNA polymerases (RNAPs) on DNA. Based on transcriptomic data, we hypothesize that RNAP collisions drive bidirectional transcription termination of convergent gene pairs. Single-molecule results show that the head-on collision between two converging RNAPs is necessary to prevent transcriptional readthrough but insufficient to release the RNAPs from the DNA. Remarkably, co-directional collision of a trailing RNAP into the head-on collided complex dramatically increases the termination efficiency. Furthermore, stem-loop structures formed in the nascent RNA are required for collisions to occur at well-defined positions between convergent genes. These findings suggest that physical collisions between RNAPs furnish a mechanism for transcription termination and that programmed genomic conflicts can be exploited to co-regulate the expression of multiple genes." @default.
- W4324101808 created "2023-03-14" @default.
- W4324101808 creator A5050487837 @default.
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- W4324101808 date "2023-04-01" @default.
- W4324101808 modified "2023-10-13" @default.
- W4324101808 title "Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination" @default.
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- W4324101808 doi "https://doi.org/10.1016/j.molcel.2023.02.017" @default.
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