Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324129056> ?p ?o ?g. }
- W4324129056 abstract "Adipocytes robustly synthesize fatty acids (FA) from carbohydrate through the de novo lipogenesis (DNL) pathway, yet surprisingly DNL contributes little to their abundant triglyceride stored in lipid droplets. This conundrum raises the hypothesis that adipocyte DNL instead enables membrane expansions to occur in processes like autophagy, which requires an abundant supply of phospholipids. We report here that adipocyte Fasn deficiency in vitro and in vivo markedly impairs autophagy, evident by autophagosome accumulation and severely compromised degradation of the autophagic substrate p62. Our data indicate the impairment occurs at the level of autophagosome-lysosome fusion, and indeed, loss of Fasn decreases certain membrane phosphoinositides necessary for autophagosome and lysosome maturation and fusion. Autophagy dependence on FA produced by Fasn is not fully alleviated by exogenous FA in cultured adipocytes, and interestingly, imaging studies reveal that Fasn colocalizes with nascent autophagosomes. Together, our studies identify DNL as a critical source of FAs to fuel autophagosome and lysosome maturation and fusion in adipocytes." @default.
- W4324129056 created "2023-03-15" @default.
- W4324129056 creator A5015721009 @default.
- W4324129056 creator A5024057589 @default.
- W4324129056 creator A5026882686 @default.
- W4324129056 creator A5046512580 @default.
- W4324129056 creator A5049994949 @default.
- W4324129056 creator A5055488258 @default.
- W4324129056 creator A5062931342 @default.
- W4324129056 creator A5062992566 @default.
- W4324129056 creator A5077386308 @default.
- W4324129056 creator A5078568037 @default.
- W4324129056 creator A5085687728 @default.
- W4324129056 creator A5086030407 @default.
- W4324129056 creator A5087869127 @default.
- W4324129056 creator A5089102700 @default.
- W4324129056 date "2023-03-13" @default.
- W4324129056 modified "2023-10-16" @default.
- W4324129056 title "De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics" @default.
- W4324129056 cites W1564494470 @default.
- W4324129056 cites W1964873147 @default.
- W4324129056 cites W1966885655 @default.
- W4324129056 cites W1972744939 @default.
- W4324129056 cites W1974279922 @default.
- W4324129056 cites W1978145149 @default.
- W4324129056 cites W1987769185 @default.
- W4324129056 cites W2007505836 @default.
- W4324129056 cites W2007890149 @default.
- W4324129056 cites W2019207756 @default.
- W4324129056 cites W2022316151 @default.
- W4324129056 cites W2023857290 @default.
- W4324129056 cites W2025189372 @default.
- W4324129056 cites W2067289453 @default.
- W4324129056 cites W2068749469 @default.
- W4324129056 cites W2079325827 @default.
- W4324129056 cites W2079569342 @default.
- W4324129056 cites W2081962941 @default.
- W4324129056 cites W2095000965 @default.
- W4324129056 cites W2097275712 @default.
- W4324129056 cites W2117454877 @default.
- W4324129056 cites W2133865500 @default.
- W4324129056 cites W2135384508 @default.
- W4324129056 cites W2143873575 @default.
- W4324129056 cites W2147240714 @default.
- W4324129056 cites W2150291178 @default.
- W4324129056 cites W2157973824 @default.
- W4324129056 cites W2172026176 @default.
- W4324129056 cites W2220707375 @default.
- W4324129056 cites W2262858406 @default.
- W4324129056 cites W2336207627 @default.
- W4324129056 cites W2517759674 @default.
- W4324129056 cites W2548058740 @default.
- W4324129056 cites W2551499720 @default.
- W4324129056 cites W2552288287 @default.
- W4324129056 cites W2561943186 @default.
- W4324129056 cites W2566416357 @default.
- W4324129056 cites W2612993240 @default.
- W4324129056 cites W2619346124 @default.
- W4324129056 cites W2736294384 @default.
- W4324129056 cites W2784145454 @default.
- W4324129056 cites W2787178457 @default.
- W4324129056 cites W2801649057 @default.
- W4324129056 cites W2888447333 @default.
- W4324129056 cites W2890761697 @default.
- W4324129056 cites W2892416438 @default.
- W4324129056 cites W2895100369 @default.
- W4324129056 cites W2905634011 @default.
- W4324129056 cites W2950604766 @default.
- W4324129056 cites W2973136302 @default.
- W4324129056 cites W2993862932 @default.
- W4324129056 cites W2994228082 @default.
- W4324129056 cites W2997832844 @default.
- W4324129056 cites W3012531604 @default.
- W4324129056 cites W3021113195 @default.
- W4324129056 cites W3023456199 @default.
- W4324129056 cites W3051468483 @default.
- W4324129056 cites W3096073302 @default.
- W4324129056 cites W3108936441 @default.
- W4324129056 cites W3114531677 @default.
- W4324129056 cites W3120360532 @default.
- W4324129056 cites W3157329740 @default.
- W4324129056 cites W3159316101 @default.
- W4324129056 cites W3163179134 @default.
- W4324129056 cites W3186632095 @default.
- W4324129056 cites W4205283001 @default.
- W4324129056 cites W4249146370 @default.
- W4324129056 cites W4291552404 @default.
- W4324129056 doi "https://doi.org/10.1038/s41467-023-37016-8" @default.
- W4324129056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36914626" @default.
- W4324129056 hasPublicationYear "2023" @default.
- W4324129056 type Work @default.
- W4324129056 citedByCount "4" @default.
- W4324129056 countsByYear W43241290562023 @default.
- W4324129056 crossrefType "journal-article" @default.
- W4324129056 hasAuthorship W4324129056A5015721009 @default.
- W4324129056 hasAuthorship W4324129056A5024057589 @default.
- W4324129056 hasAuthorship W4324129056A5026882686 @default.
- W4324129056 hasAuthorship W4324129056A5046512580 @default.
- W4324129056 hasAuthorship W4324129056A5049994949 @default.
- W4324129056 hasAuthorship W4324129056A5055488258 @default.