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- W4324130043 abstract "The term bioanalytical encompasses a much greater breadth of analytical deliverables than ever before. Circulating drug concentration data are complemented by experimental evidence of drug in biophase, immunogenicity, target engagement and subsequent pathway modulation. Many bioanalytical assays bridge the traditional divide across discovery and development. Our approach is the Bioanalytical Hub model bringing together a wide breadth of bioanalytical support (GxP and non-GxP), multiple end points (pharmacokinetics, anti-drug antibodies and biomarkers) and analytical platforms (LC/MS, immunoassay, flow cytometry, genomics, immunohistochemistry) onto a common lab footprint. This maximizes instrument utilization, facilitates workforce agility and enhances data interpretation capability while reducing the number of hand-offs as assays evolve from their origins as exploratory end points to fully characterized to support primary and secondary end points." @default.
- W4324130043 created "2023-03-15" @default.
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- W4324130043 date "2023-03-14" @default.
- W4324130043 modified "2023-09-29" @default.
- W4324130043 title "GSK Bioanalytical Hub model in bioanalysis: maximizing the synergies of co-locating various platforms in support of regulated and nonregulated study endpoints" @default.
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- W4324130043 doi "https://doi.org/10.4155/bio-2022-0180" @default.
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- W4324130043 hasPublicationYear "2023" @default.
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