FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324130101> ?p ?o ?g. }

• W4324130101 endingPage "2216" @default.
• W4324130101 startingPage "2211" @default.
• W4324130101 abstract "Enteroendocrine N cells secrete neurotensin (NTS). NTS reduces food intake in rodents and may increase insulin release. In humans, postprandial NTS responses increase following Roux-en-Y gastric bypass, associating the hormone with the glucose- and body weight-lowering effects of these procedures.We looked at N cell density and mucosal messenger RNA (mRNA) expression profiles of NTS and NTS receptors in type 2 diabetes (T2D) patients and healthy controls.Using double-balloon enteroscopy, 12 patients with T2D and 12 sex-, age-, and body mass index-matched healthy controls had mucosa biopsies taken from the entire length of the small intestine (at 30-cm intervals) and from 7 anatomically well-defined locations in the large intestine. Biopsies were analyzed using immunohistochemistry and mRNA sequencing.N cell density and NTS mRNA expression gradually increased from the duodenum to the ileum, while negligible NTS-positive cells and NTS mRNA expression were observed in the large intestine. NTS receptor 1 and 2 mRNA expression were not detected, but sortilin, a single-pass transmembrane neuropeptide receptor of which NTS also is a ligand, was uniformly expressed in the intestines. Patients with T2D exhibited lower levels of NTS-positive cells and mRNA expression than healthy controls, but this was not statistically significant after adjusting for multiple testing.This unique intestinal mapping of N cell density and NTS expression shows increasing levels from the small intestine's proximal to distal end (without differences between patients with T2D and healthy controls), while negligible N-cells and NTS mRNA expression were observed in the large intestine. Sortilin was expressed throughout the intestines in both groups; no NTS receptor 1 or 2 mRNA expression were detected." @default.
• W4324130101 created "2023-03-15" @default.
• W4324130101 creator A5004120950 @default.
• W4324130101 creator A5012730815 @default.
• W4324130101 creator A5023486891 @default.
• W4324130101 creator A5030519271 @default.
• W4324130101 creator A5070751349 @default.
• W4324130101 creator A5079352451 @default.
• W4324130101 creator A5082050584 @default.
• W4324130101 creator A5086797250 @default.
• W4324130101 date "2023-03-14" @default.
• W4324130101 modified "2023-10-14" @default.
• W4324130101 title "Expression of Neurotensin and Its Receptors Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls" @default.
• W4324130101 cites W1983903555 @default.
• W4324130101 cites W2002101681 @default.
• W4324130101 cites W2008837690 @default.
• W4324130101 cites W2032906507 @default.
• W4324130101 cites W2056603063 @default.
• W4324130101 cites W2057445381 @default.
• W4324130101 cites W2079833534 @default.
• W4324130101 cites W2106129453 @default.
• W4324130101 cites W2108412174 @default.
• W4324130101 cites W2140616393 @default.
• W4324130101 cites W2261667570 @default.
• W4324130101 cites W2375950438 @default.
• W4324130101 cites W2403447156 @default.
• W4324130101 cites W2476647923 @default.
• W4324130101 cites W2757755247 @default.
• W4324130101 cites W2926297340 @default.
• W4324130101 cites W3095701042 @default.
• W4324130101 cites W3129864823 @default.
• W4324130101 cites W3164567833 @default.
• W4324130101 cites W3184729641 @default.
• W4324130101 cites W3191434150 @default.
• W4324130101 cites W3199375638 @default.
• W4324130101 doi "https://doi.org/10.1210/clinem/dgad146" @default.
• W4324130101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36916883" @default.
• W4324130101 hasPublicationYear "2023" @default.
• W4324130101 type Work @default.
• W4324130101 citedByCount "0" @default.
• W4324130101 crossrefType "journal-article" @default.
• W4324130101 hasAuthorship W4324130101A5004120950 @default.
• W4324130101 hasAuthorship W4324130101A5012730815 @default.
• W4324130101 hasAuthorship W4324130101A5023486891 @default.
• W4324130101 hasAuthorship W4324130101A5030519271 @default.
• W4324130101 hasAuthorship W4324130101A5070751349 @default.
• W4324130101 hasAuthorship W4324130101A5079352451 @default.
• W4324130101 hasAuthorship W4324130101A5082050584 @default.
• W4324130101 hasAuthorship W4324130101A5086797250 @default.
• W4324130101 hasBestOaLocation W43241301011 @default.
• W4324130101 hasConcept C103395026 @default.
• W4324130101 hasConcept C104317684 @default.
• W4324130101 hasConcept C105580179 @default.
• W4324130101 hasConcept C118303440 @default.
• W4324130101 hasConcept C126322002 @default.
• W4324130101 hasConcept C134018914 @default.
• W4324130101 hasConcept C170493617 @default.
• W4324130101 hasConcept C2777226302 @default.
• W4324130101 hasConcept C2777882243 @default.
• W4324130101 hasConcept C2778976297 @default.
• W4324130101 hasConcept C46699223 @default.
• W4324130101 hasConcept C55493867 @default.
• W4324130101 hasConcept C71315377 @default.
• W4324130101 hasConcept C71924100 @default.
• W4324130101 hasConcept C81439078 @default.
• W4324130101 hasConcept C86803240 @default.
• W4324130101 hasConceptScore W4324130101C103395026 @default.
• W4324130101 hasConceptScore W4324130101C104317684 @default.
• W4324130101 hasConceptScore W4324130101C105580179 @default.
• W4324130101 hasConceptScore W4324130101C118303440 @default.
• W4324130101 hasConceptScore W4324130101C126322002 @default.
• W4324130101 hasConceptScore W4324130101C134018914 @default.
• W4324130101 hasConceptScore W4324130101C170493617 @default.
• W4324130101 hasConceptScore W4324130101C2777226302 @default.
• W4324130101 hasConceptScore W4324130101C2777882243 @default.
• W4324130101 hasConceptScore W4324130101C2778976297 @default.
• W4324130101 hasConceptScore W4324130101C46699223 @default.
• W4324130101 hasConceptScore W4324130101C55493867 @default.
• W4324130101 hasConceptScore W4324130101C71315377 @default.
• W4324130101 hasConceptScore W4324130101C71924100 @default.
• W4324130101 hasConceptScore W4324130101C81439078 @default.
• W4324130101 hasConceptScore W4324130101C86803240 @default.
• W4324130101 hasFunder F4320320945 @default.
• W4324130101 hasFunder F4320321590 @default.
• W4324130101 hasFunder F4320324938 @default.
• W4324130101 hasFunder F4320325957 @default.
• W4324130101 hasIssue "9" @default.
• W4324130101 hasLocation W43241301011 @default.
• W4324130101 hasLocation W43241301012 @default.
• W4324130101 hasOpenAccess W4324130101 @default.
• W4324130101 hasPrimaryLocation W43241301011 @default.
• W4324130101 hasRelatedWork W1965498821 @default.
• W4324130101 hasRelatedWork W1978930407 @default.
• W4324130101 hasRelatedWork W2062633278 @default.
• W4324130101 hasRelatedWork W2062767376 @default.
• W4324130101 hasRelatedWork W2063619316 @default.
• W4324130101 hasRelatedWork W2067421416 @default.
• W4324130101 hasRelatedWork W2067761507 @default.

• next