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- W4324130422 endingPage "410" @default.
- W4324130422 startingPage "396" @default.
- W4324130422 abstract "Chimeric antigen receptor (CAR) T cells targeting CD19 represent a promising salvage immunotherapy for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), offering ~40% of long-term responses. In everyday clinical practice, haematologists involved in CAR T cell treatment of patients with R/R DLBCL have to deal with diagnostically complex cases and difficult therapeutic choices. The availability of novel immunotherapeutic agents for R/R DLBCL and recent advances in understanding CAR T-cell failure mechanisms demand a rational approach to identify the best choice for bridging therapy and managing post-CAR T-cell therapy relapses. Moreover, positron emission tomography/computerised tomography may result in false-positive interpretation, highlighting the importance of post-treatment biopsy. In this review, we discuss all above issues, presenting four instructive cases, with the aim to provide criteria and new perspectives for CAR T-cell treatment of DLBCL." @default.
- W4324130422 created "2023-03-15" @default.
- W4324130422 creator A5058925624 @default.
- W4324130422 creator A5064807044 @default.
- W4324130422 creator A5073503794 @default.
- W4324130422 creator A5074218414 @default.
- W4324130422 date "2023-03-14" @default.
- W4324130422 modified "2023-09-26" @default.
- W4324130422 title "How I treat refractory/relapsed diffuse large B‐cell lymphomas with <scp>CD19</scp>‐directed <scp>chimeric antigen receptor</scp> T cells" @default.
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