Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324130921> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4324130921 abstract "Hypoxia imaging for surgical guidance has never been possible, yet it is well known that most tumors have microregional chronic and/or cycling hypoxia present as well as chaotic blood flow. The ability to image oxygen partial pressure (pO<sub>2</sub>) is therefore a unique control of tissue metabolism and can be used in a range of disease applications to understand the complex biochemistry of oxygen supply and consumption. Delayed fluorescence (DF) from the endogenous molecule protoporphyrin IX (PpIX) has been shown to be a truly unique reporter of the local oxygen partial pressure in tissue. PpIX is endogenously synthesized by mitochondria in most tissues and the particular property of DF emission is directly related to low microenvironmental oxygen concentration. Here it is shown that protoporphyrin IX (PpIX) has a unique emission in hypoxic tumor tissue regions, that is measured as a delayed fluorescence (DF) signal in the red to near-infrared spectrum. A time-gated imaging system was used for PpIX DF for wide field direct mapping of pO<sub>2</sub> changes. Acquiring both prompt and delayed fluorescence in a rapid sequential cycle allowed for imaging oxygenation in a way that was insensitive to the PpIX concentration. By choosing adequate parameters, the video rate acquisition of pO<sub>2</sub> images could be achieved, providing real-time tissue metabolic information. In this report, we show the first demonstration of imaging hypoxia signals from PpIX in a pancreatic cancer model, exhibiting >5X contrast relative to surrounding normal oxygenated tissues. Additionally, tissue palpation amplifies the signal and provides intuitive temporal contrast based upon neoangiogenic blood flow differences. PpIX DF provides a new mechanism for tumor contrast that could easily be translated to human use as an intrinsic contrast mechanism for oncologic surgical guidance." @default.
- W4324130921 created "2023-03-15" @default.
- W4324130921 creator A5034561361 @default.
- W4324130921 creator A5068318890 @default.
- W4324130921 creator A5089497655 @default.
- W4324130921 date "2023-03-15" @default.
- W4324130921 modified "2023-09-27" @default.
- W4324130921 title "Protoporphyrin IX delayed fluorescence imaging: a modality for wide range surgical guidance" @default.
- W4324130921 cites W2017680893 @default.
- W4324130921 cites W2035950553 @default.
- W4324130921 cites W2060238620 @default.
- W4324130921 cites W2094866017 @default.
- W4324130921 cites W2112543105 @default.
- W4324130921 cites W2117674055 @default.
- W4324130921 cites W2150240082 @default.
- W4324130921 cites W2290466312 @default.
- W4324130921 cites W2519265738 @default.
- W4324130921 cites W2748653155 @default.
- W4324130921 cites W2910072132 @default.
- W4324130921 cites W2965134638 @default.
- W4324130921 cites W2998616058 @default.
- W4324130921 cites W3017612988 @default.
- W4324130921 cites W3100271940 @default.
- W4324130921 cites W3138429678 @default.
- W4324130921 cites W3204902068 @default.
- W4324130921 cites W3207500668 @default.
- W4324130921 cites W4239261847 @default.
- W4324130921 cites W4362597612 @default.
- W4324130921 doi "https://doi.org/10.1117/12.2646721" @default.
- W4324130921 hasPublicationYear "2023" @default.
- W4324130921 type Work @default.
- W4324130921 citedByCount "0" @default.
- W4324130921 crossrefType "proceedings-article" @default.
- W4324130921 hasAuthorship W4324130921A5034561361 @default.
- W4324130921 hasAuthorship W4324130921A5068318890 @default.
- W4324130921 hasAuthorship W4324130921A5089497655 @default.
- W4324130921 hasConcept C120665830 @default.
- W4324130921 hasConcept C121332964 @default.
- W4324130921 hasConcept C12554922 @default.
- W4324130921 hasConcept C126322002 @default.
- W4324130921 hasConcept C178790620 @default.
- W4324130921 hasConcept C185592680 @default.
- W4324130921 hasConcept C2779081379 @default.
- W4324130921 hasConcept C2779671804 @default.
- W4324130921 hasConcept C2781323092 @default.
- W4324130921 hasConcept C46141821 @default.
- W4324130921 hasConcept C509974204 @default.
- W4324130921 hasConcept C540031477 @default.
- W4324130921 hasConcept C57477423 @default.
- W4324130921 hasConcept C68463220 @default.
- W4324130921 hasConcept C70289976 @default.
- W4324130921 hasConcept C71924100 @default.
- W4324130921 hasConcept C7836513 @default.
- W4324130921 hasConcept C86803240 @default.
- W4324130921 hasConcept C91881484 @default.
- W4324130921 hasConceptScore W4324130921C120665830 @default.
- W4324130921 hasConceptScore W4324130921C121332964 @default.
- W4324130921 hasConceptScore W4324130921C12554922 @default.
- W4324130921 hasConceptScore W4324130921C126322002 @default.
- W4324130921 hasConceptScore W4324130921C178790620 @default.
- W4324130921 hasConceptScore W4324130921C185592680 @default.
- W4324130921 hasConceptScore W4324130921C2779081379 @default.
- W4324130921 hasConceptScore W4324130921C2779671804 @default.
- W4324130921 hasConceptScore W4324130921C2781323092 @default.
- W4324130921 hasConceptScore W4324130921C46141821 @default.
- W4324130921 hasConceptScore W4324130921C509974204 @default.
- W4324130921 hasConceptScore W4324130921C540031477 @default.
- W4324130921 hasConceptScore W4324130921C57477423 @default.
- W4324130921 hasConceptScore W4324130921C68463220 @default.
- W4324130921 hasConceptScore W4324130921C70289976 @default.
- W4324130921 hasConceptScore W4324130921C71924100 @default.
- W4324130921 hasConceptScore W4324130921C7836513 @default.
- W4324130921 hasConceptScore W4324130921C86803240 @default.
- W4324130921 hasConceptScore W4324130921C91881484 @default.
- W4324130921 hasLocation W43241309211 @default.
- W4324130921 hasOpenAccess W4324130921 @default.
- W4324130921 hasPrimaryLocation W43241309211 @default.
- W4324130921 hasRelatedWork W2020509581 @default.
- W4324130921 hasRelatedWork W2027983135 @default.
- W4324130921 hasRelatedWork W2031420641 @default.
- W4324130921 hasRelatedWork W2051490559 @default.
- W4324130921 hasRelatedWork W2148084400 @default.
- W4324130921 hasRelatedWork W2297045668 @default.
- W4324130921 hasRelatedWork W2327585540 @default.
- W4324130921 hasRelatedWork W2972506498 @default.
- W4324130921 hasRelatedWork W4324130921 @default.
- W4324130921 hasRelatedWork W2079326583 @default.
- W4324130921 isParatext "false" @default.
- W4324130921 isRetracted "false" @default.
- W4324130921 workType "article" @default.