FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324131026> ?p ?o ?g. }

• W4324131026 abstract "Abstract In individuals with Down syndrome (DS), cardiovascular and pulmonary diseases are the most common health problem and result in increased mortality and morbidity. Although these clinical comorbidities are well described, no preclinical models for DS are fully characterized for cardiopulmonary alterations, preventing research to understanding the development and pharmacological modulation of lungs, heart and immune system. Our objective is to characterize the cardiopulmonary and immunological phenotype in Ts65Dn mice and investigate the modulatory effects green tea extract enriched in epigallocatechin 3 gallate (GTE-EGCG). GTE-EGCG administration started at embryonic day 9 and was discontinued at postnatal day (PD) 180. Newborns were longitudinally monitored until PD210 using micro-computed tomography. At endpoint, we characterized the structural, functional and immunological alterations and persistent effects of GTE-EGCG administration. This study revealed normal lung development in the Ts65Dn mice and highlighted RV hypertrophy and immunological alterations. GTE-EGCG administration resulted in genotype-specific and genotype-independent alterations resulting in lung immaturation and airway hyperreactivity. Our results highlight the cardiovascular and immunological phenotype of Ts65Dn mice and potential use for safety studies of therapeutic agents in a DS-specific context. Summary statement This study longitudinally follows respiratory and cardiac alterations in the Ts65Dn mouse model and describes the impact of prenatal EGCG modulation on the euploid and trisomic phenotype" @default.
• W4324131026 created "2023-03-15" @default.
• W4324131026 creator A5001826243 @default.
• W4324131026 creator A5027046048 @default.
• W4324131026 creator A5037315125 @default.
• W4324131026 creator A5039462120 @default.
• W4324131026 creator A5045770684 @default.
• W4324131026 creator A5048235718 @default.
• W4324131026 creator A5048631132 @default.
• W4324131026 creator A5058591852 @default.
• W4324131026 creator A5065124015 @default.
• W4324131026 creator A5070413722 @default.
• W4324131026 creator A5078947571 @default.
• W4324131026 creator A5081136840 @default.
• W4324131026 creator A5085099013 @default.
• W4324131026 creator A5087565405 @default.
• W4324131026 date "2023-03-14" @default.
• W4324131026 modified "2023-09-29" @default.
• W4324131026 title "Cardiopulmonary structural, functional and immune-alterations in a Down syndrome mouse model and upon modulation of EGCG" @default.
• W4324131026 cites W1536916194 @default.
• W4324131026 cites W1833314573 @default.
• W4324131026 cites W1966836247 @default.
• W4324131026 cites W1968285655 @default.
• W4324131026 cites W1989786762 @default.
• W4324131026 cites W1995198589 @default.
• W4324131026 cites W1997381668 @default.
• W4324131026 cites W2024230218 @default.
• W4324131026 cites W2047570886 @default.
• W4324131026 cites W2051685982 @default.
• W4324131026 cites W2053592674 @default.
• W4324131026 cites W2056538157 @default.
• W4324131026 cites W2070785261 @default.
• W4324131026 cites W2079973367 @default.
• W4324131026 cites W2082185509 @default.
• W4324131026 cites W2083356680 @default.
• W4324131026 cites W2084258017 @default.
• W4324131026 cites W2099999081 @default.
• W4324131026 cites W2100022178 @default.
• W4324131026 cites W2124873041 @default.
• W4324131026 cites W2131513300 @default.
• W4324131026 cites W2140109458 @default.
• W4324131026 cites W2147621858 @default.
• W4324131026 cites W2178337429 @default.
• W4324131026 cites W2194591868 @default.
• W4324131026 cites W2195622203 @default.
• W4324131026 cites W2273554450 @default.
• W4324131026 cites W2292508045 @default.
• W4324131026 cites W2303984800 @default.
• W4324131026 cites W2318544461 @default.
• W4324131026 cites W2413465592 @default.
• W4324131026 cites W2416008031 @default.
• W4324131026 cites W2428634689 @default.
• W4324131026 cites W2507240154 @default.
• W4324131026 cites W2523095427 @default.
• W4324131026 cites W2540450122 @default.
• W4324131026 cites W2611047521 @default.
• W4324131026 cites W2614800859 @default.
• W4324131026 cites W2756004609 @default.
• W4324131026 cites W2762704480 @default.
• W4324131026 cites W2794406378 @default.
• W4324131026 cites W2799892338 @default.
• W4324131026 cites W2800640372 @default.
• W4324131026 cites W2884265917 @default.
• W4324131026 cites W2945420937 @default.
• W4324131026 cites W2979642160 @default.
• W4324131026 cites W3040954058 @default.
• W4324131026 cites W3041353096 @default.
• W4324131026 cites W3130908611 @default.
• W4324131026 cites W3148099720 @default.
• W4324131026 cites W3174898664 @default.
• W4324131026 cites W3204292891 @default.
• W4324131026 cites W3209395263 @default.
• W4324131026 cites W4200312492 @default.
• W4324131026 cites W4205772173 @default.
• W4324131026 cites W4211072041 @default.
• W4324131026 cites W4303962245 @default.
• W4324131026 doi "https://doi.org/10.1101/2023.03.13.532396" @default.
• W4324131026 hasPublicationYear "2023" @default.
• W4324131026 type Work @default.
• W4324131026 citedByCount "0" @default.
• W4324131026 crossrefType "posted-content" @default.
• W4324131026 hasAuthorship W4324131026A5001826243 @default.
• W4324131026 hasAuthorship W4324131026A5027046048 @default.
• W4324131026 hasAuthorship W4324131026A5037315125 @default.
• W4324131026 hasAuthorship W4324131026A5039462120 @default.
• W4324131026 hasAuthorship W4324131026A5045770684 @default.
• W4324131026 hasAuthorship W4324131026A5048235718 @default.
• W4324131026 hasAuthorship W4324131026A5048631132 @default.
• W4324131026 hasAuthorship W4324131026A5058591852 @default.
• W4324131026 hasAuthorship W4324131026A5065124015 @default.
• W4324131026 hasAuthorship W4324131026A5070413722 @default.
• W4324131026 hasAuthorship W4324131026A5078947571 @default.
• W4324131026 hasAuthorship W4324131026A5081136840 @default.
• W4324131026 hasAuthorship W4324131026A5085099013 @default.
• W4324131026 hasAuthorship W4324131026A5087565405 @default.
• W4324131026 hasBestOaLocation W43241310261 @default.
• W4324131026 hasConcept C104317684 @default.
• W4324131026 hasConcept C126322002 @default.
• W4324131026 hasConcept C127716648 @default.
• W4324131026 hasConcept C151730666 @default.

• next