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• W4324132352 abstract "MGB polyamide-oligonucleotide conjugates ON 1-4 with linked MGB polyamides at the 2-exocyclic amino group of a guanine base using aminoalkyl linkers were synthesized and evaluated in terms of binding affinity for complementary DNA containing the MGB polyamide binding sequence using Tm and CD analyses. The MGB polyamides comprised pyrrole polyamides (Py4- and Py3-), which possess binding affinity for A-T base pairs, and imidazole (Im3-) and pyrrole-γ-imidazole (Py3-γ-Im3-) polyamide hairpin motifs, which possess binding affinity for C-G base pairs. It was found that the stability of modified dsDNA was greatly influenced by the linker length. Py4- and Py3-oligonucleotide conjugates (ON 1 ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>n</mi> <mo>=</mo> <mn>4</mn> </math> ) and ON 2 ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>n</mi> <mo>=</mo> <mn>4</mn> </math> )) containing the 4-aminobutyl linker formed stable dsDNA with complementary DNA. Although Im3-oligonucleotide conjugate ON 3 ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>n</mi> <mo>=</mo> <mn>4</mn> </math> ) containing the 4-aminobutyl linker formed stable dsDNA with complementary DNA, stabilization of dsDNA by the imidazole amide moiety of ON 3 ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>n</mi> <mo>=</mo> <mn>4</mn> </math> ) was lower compared with the pyrrole amide moiety of ON 2 ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mi>n</mi> <mo>=</mo> <mn>4</mn> </math> ). The Py3-γ-Im3-oligonucleotide conjugate ON 4 ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M6> <mi>n</mi> <mo>=</mo> <mn>2</mn> </math> ), which possesses binding affinity for C-G base pairs via a pyrrole/imidazole combination and contains a 2-aminoethyl linker, showed high binding ability for complementary DNA. Furthermore, the DNA sequence recognition of MGB polyamide-oligonucleotide conjugates was investigated using single-base mismatch DNAs, which possess a mismatch base in the MGB polyamide binding sequence. The Py3-γ-Im3-oligonucleotide conjugate ON 4 ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M7> <mi>n</mi> <mo>=</mo> <mn>2</mn> </math> ) showed high sequence recognition ability for complementary DNA." @default.
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• W4324132352 date "2023-03-14" @default.
• W4324132352 modified "2023-09-26" @default.
• W4324132352 title "Synthesis and Evaluation of MGB Polyamide-Oligonucleotide Conjugates as Gene Expression Control Compounds" @default.
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• W4324132352 doi "https://doi.org/10.1155/2023/2447998" @default.
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