Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324133788> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4324133788 abstract "Ornithine-free Gramicidin S (1, cyclo(Val-Leu-Leu-D-Phe-Pro)2) is a good scaffold for studying β-turn and sheet structures. 4-Fluororide proline was incorporated into 1, and the resulting puckering of Pro was evaluated. Two geometric isomers, trans-4-fluoro-Pro and cis-4-fluoro-Pro, were incorporated into peptides 2 and 3, respectively. 4,4-Difluoro-Pro, which had no isomer, was incorporated into 4. The fluoro-analogues of 2–4 formed sheet and β-turn structures. The “up” forms (Cβ-endo and Cγ-exo) of Pro were found in 2, which is their first observation in Gramicidin S analogues. The “down” forms (Cβ-exo), which have been observed previously in GS analogues, were found in 3 and 4. Energy minimization indicated a 3–4% energy benefit in the “down” form. 4-Fluororide proline was incorporated into Ornithine-free Gramicidin S, and the resulting puckering of Pro (pyrrolidine ring) was evaluated. The “up” forms of Pro were found, which is the first observation in Gramicidin S analogues. Energy minimization indicated a 3–4% energy benefit in the “down” form." @default.
- W4324133788 created "2023-03-15" @default.
- W4324133788 creator A5011005510 @default.
- W4324133788 creator A5015294998 @default.
- W4324133788 creator A5064971574 @default.
- W4324133788 creator A5085075262 @default.
- W4324133788 date "2023-03-15" @default.
- W4324133788 modified "2023-09-25" @default.
- W4324133788 title "Puckering of 4-Fluoro-L-Proline Isomers and 4,4-Difluoro-L-Proline Influencing Conformation of Ornithine-Free Gramicidin S" @default.
- W4324133788 doi "https://doi.org/10.1246/cl.230063" @default.
- W4324133788 hasPublicationYear "2023" @default.
- W4324133788 type Work @default.
- W4324133788 citedByCount "0" @default.
- W4324133788 crossrefType "journal-article" @default.
- W4324133788 hasAuthorship W4324133788A5011005510 @default.
- W4324133788 hasAuthorship W4324133788A5015294998 @default.
- W4324133788 hasAuthorship W4324133788A5064971574 @default.
- W4324133788 hasAuthorship W4324133788A5085075262 @default.
- W4324133788 hasConcept C176788430 @default.
- W4324133788 hasConcept C185592680 @default.
- W4324133788 hasConcept C2776796294 @default.
- W4324133788 hasConcept C2777468819 @default.
- W4324133788 hasConcept C2778851528 @default.
- W4324133788 hasConcept C2779380641 @default.
- W4324133788 hasConcept C2779650302 @default.
- W4324133788 hasConcept C2779815552 @default.
- W4324133788 hasConcept C41625074 @default.
- W4324133788 hasConcept C515207424 @default.
- W4324133788 hasConcept C55493867 @default.
- W4324133788 hasConcept C71240020 @default.
- W4324133788 hasConcept C75079739 @default.
- W4324133788 hasConceptScore W4324133788C176788430 @default.
- W4324133788 hasConceptScore W4324133788C185592680 @default.
- W4324133788 hasConceptScore W4324133788C2776796294 @default.
- W4324133788 hasConceptScore W4324133788C2777468819 @default.
- W4324133788 hasConceptScore W4324133788C2778851528 @default.
- W4324133788 hasConceptScore W4324133788C2779380641 @default.
- W4324133788 hasConceptScore W4324133788C2779650302 @default.
- W4324133788 hasConceptScore W4324133788C2779815552 @default.
- W4324133788 hasConceptScore W4324133788C41625074 @default.
- W4324133788 hasConceptScore W4324133788C515207424 @default.
- W4324133788 hasConceptScore W4324133788C55493867 @default.
- W4324133788 hasConceptScore W4324133788C71240020 @default.
- W4324133788 hasConceptScore W4324133788C75079739 @default.
- W4324133788 hasLocation W43241337881 @default.
- W4324133788 hasOpenAccess W4324133788 @default.
- W4324133788 hasPrimaryLocation W43241337881 @default.
- W4324133788 hasRelatedWork W1977978207 @default.
- W4324133788 hasRelatedWork W1996187565 @default.
- W4324133788 hasRelatedWork W2047575788 @default.
- W4324133788 hasRelatedWork W2053581150 @default.
- W4324133788 hasRelatedWork W2104881976 @default.
- W4324133788 hasRelatedWork W2466471868 @default.
- W4324133788 hasRelatedWork W2950874227 @default.
- W4324133788 hasRelatedWork W2951902443 @default.
- W4324133788 hasRelatedWork W4324133788 @default.
- W4324133788 hasRelatedWork W1994708416 @default.
- W4324133788 isParatext "false" @default.
- W4324133788 isRetracted "false" @default.
- W4324133788 workType "article" @default.