Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324134098> ?p ?o ?g. }
- W4324134098 endingPage "810" @default.
- W4324134098 startingPage "795" @default.
- W4324134098 abstract "Corticotropin-releasing factor and its primary receptor (CRFR1) are critical regulators of behavioral and neuroendocrine stress responses. CRFR1 has also been associated with stress-related behavioral changes in postpartum mice. Our previous studies indicate dynamic changes in CRFR1 levels and coupling of CRFR1 with tyrosine hydroxylase (TH) and oxytocin (OT) neurons in postpartum mice. In this study, we aimed to determine the time course of these changes during the postpartum period.Using a CRFR1-GFP reporter mouse line, we compared postpartum mice at five time points with nulliparous mice. We performed immunohistochemistry to assess changes in CRFR1 levels and changes in co-expression of TH/CRFR1-GFP and OT/CRFR1-GFP across the postpartum period. Mice were also assessed for behavioral stress responses in the open field test.Relative to nulliparous mice, CRFR1 levels were elevated in the anteroventral periventricular nucleus (AVPV/PeN) but were decreased in the medial preoptic area from postpartum day 1 (P1) through P28. In the paraventricular hypothalamus (PVN), there is a transient decline in CRFR1 mid-postpartum with a nadir at P7. Co-localization of CRFR1 with TH-expressing neurons was also altered with a transient decrease found in the AVPV/PeN at P7 and P14. Co-expression of CRFR1 and OT neurons of the PVN and supraoptic nucleus was dramatically altered with virtually no co-expression found in nulliparous mice, but levels increased shortly after parturition and peaked near P21. A transient decrease in open field center time was found at P7, indicating elevated anxiety-like behavior.This study revealed various changes in CRFR1 across the postpartum period, which may contribute to stress-related behavior changes in postpartum mice." @default.
- W4324134098 created "2023-03-15" @default.
- W4324134098 creator A5005734707 @default.
- W4324134098 creator A5006434191 @default.
- W4324134098 creator A5020146386 @default.
- W4324134098 creator A5022552663 @default.
- W4324134098 creator A5027511446 @default.
- W4324134098 creator A5044473867 @default.
- W4324134098 creator A5045808250 @default.
- W4324134098 creator A5061871956 @default.
- W4324134098 creator A5063074821 @default.
- W4324134098 creator A5074340017 @default.
- W4324134098 creator A5074366568 @default.
- W4324134098 creator A5079701180 @default.
- W4324134098 creator A5091592958 @default.
- W4324134098 date "2023-01-01" @default.
- W4324134098 modified "2023-09-27" @default.
- W4324134098 title "Changes in corticotropin releasing factor receptor type 1, co-expression with tyrosine hydroxylase and oxytocin neurons, and anxiety-like behaviors across the postpartum period in mice" @default.
- W4324134098 cites W1218374853 @default.
- W4324134098 cites W1516855691 @default.
- W4324134098 cites W1572525448 @default.
- W4324134098 cites W1886714202 @default.
- W4324134098 cites W1919151020 @default.
- W4324134098 cites W1965160371 @default.
- W4324134098 cites W1965701483 @default.
- W4324134098 cites W1970590111 @default.
- W4324134098 cites W1975218744 @default.
- W4324134098 cites W1985694975 @default.
- W4324134098 cites W1986576876 @default.
- W4324134098 cites W1995176921 @default.
- W4324134098 cites W2005828107 @default.
- W4324134098 cites W2008690448 @default.
- W4324134098 cites W2021688170 @default.
- W4324134098 cites W2030012898 @default.
- W4324134098 cites W2035071652 @default.
- W4324134098 cites W2040290427 @default.
- W4324134098 cites W2047810860 @default.
- W4324134098 cites W2052184070 @default.
- W4324134098 cites W2058334605 @default.
- W4324134098 cites W2060197642 @default.
- W4324134098 cites W2069120351 @default.
- W4324134098 cites W2072955966 @default.
- W4324134098 cites W2079283607 @default.
- W4324134098 cites W2084255057 @default.
- W4324134098 cites W2086615652 @default.
- W4324134098 cites W2094561620 @default.
- W4324134098 cites W2095036452 @default.
- W4324134098 cites W2113343801 @default.
- W4324134098 cites W2115194311 @default.
- W4324134098 cites W2118238128 @default.
- W4324134098 cites W2119951209 @default.
- W4324134098 cites W2124751622 @default.
- W4324134098 cites W2124751829 @default.
- W4324134098 cites W2126611626 @default.
- W4324134098 cites W2127552596 @default.
- W4324134098 cites W2141843569 @default.
- W4324134098 cites W2146783129 @default.
- W4324134098 cites W2149878393 @default.
- W4324134098 cites W2162313714 @default.
- W4324134098 cites W2173349838 @default.
- W4324134098 cites W2179438025 @default.
- W4324134098 cites W2197950776 @default.
- W4324134098 cites W2228972169 @default.
- W4324134098 cites W2234931122 @default.
- W4324134098 cites W2240151620 @default.
- W4324134098 cites W2582627625 @default.
- W4324134098 cites W2591590721 @default.
- W4324134098 cites W2748566999 @default.
- W4324134098 cites W2777121311 @default.
- W4324134098 cites W2784606915 @default.
- W4324134098 cites W2791852824 @default.
- W4324134098 cites W2796795556 @default.
- W4324134098 cites W2800988908 @default.
- W4324134098 cites W2814143751 @default.
- W4324134098 cites W2902341990 @default.
- W4324134098 cites W2912254165 @default.
- W4324134098 cites W2942918775 @default.
- W4324134098 cites W2967157647 @default.
- W4324134098 cites W2995016588 @default.
- W4324134098 cites W2998841239 @default.
- W4324134098 cites W3008371933 @default.
- W4324134098 cites W3196702573 @default.
- W4324134098 cites W4294904025 @default.
- W4324134098 cites W2923776870 @default.
- W4324134098 doi "https://doi.org/10.1159/000530156" @default.
- W4324134098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36917957" @default.
- W4324134098 hasPublicationYear "2023" @default.
- W4324134098 type Work @default.
- W4324134098 citedByCount "0" @default.
- W4324134098 crossrefType "journal-article" @default.
- W4324134098 hasAuthorship W4324134098A5005734707 @default.
- W4324134098 hasAuthorship W4324134098A5006434191 @default.
- W4324134098 hasAuthorship W4324134098A5020146386 @default.
- W4324134098 hasAuthorship W4324134098A5022552663 @default.
- W4324134098 hasAuthorship W4324134098A5027511446 @default.
- W4324134098 hasAuthorship W4324134098A5044473867 @default.
- W4324134098 hasAuthorship W4324134098A5045808250 @default.
- W4324134098 hasAuthorship W4324134098A5061871956 @default.