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- W4324134293 abstract "Abstract Alzheimer's disease is the most common age-associated neurodegenerative disorder and the most frequent form of dementia in our society. Aging is a complex biological process concurrently shaped by genetic, dietary and environmental factors and natural compounds are emerging for their beneficial effects against age-related disorders. Besides their antioxidant activity often described in simple model organisms, the molecular mechanisms underlying the beneficial effects of different dietary compounds remain however largely unknown. In the present study, we exploit the nematode Caenorhabditis elegans as a widely established model for aging studies, to test the effects of different natural compounds in vivo and focused on mechanistic aspects of one of them, quercetin, using complementary systems and assays. We show that quercetin has evolutionarily conserved beneficial effects against AD pathology: it prevents Aβ-induced detrimental effects in different C. elegans AD models and it reduces Aβ-secretion in mammalian cells. Mechanistically, we found that the beneficial effects of quercetin are mediated by autophagy-dependent reduced expression of Abl tyrosine kinase. In turn, autophagy is required upon Abl suppression to mediate quercetin’s protective effects against Aβ toxicity. Our data support the power of C. elegans as an in vivo model to investigate therapeutic options for Alzheimer disease." @default.
- W4324134293 created "2023-03-15" @default.
- W4324134293 creator A5005787961 @default.
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- W4324134293 date "2023-03-14" @default.
- W4324134293 modified "2023-10-16" @default.
- W4324134293 title "Abl depletion via autophagy mediates the beneficial effects of quercetin against Alzheimer pathology across species" @default.
- W4324134293 cites W1507030306 @default.
- W4324134293 cites W1558528060 @default.
- W4324134293 cites W1565091280 @default.
- W4324134293 cites W1602771322 @default.
- W4324134293 cites W1602872921 @default.
- W4324134293 cites W1843375109 @default.
- W4324134293 cites W1947804549 @default.
- W4324134293 cites W1963579854 @default.
- W4324134293 cites W1973415774 @default.
- W4324134293 cites W1973779722 @default.
- W4324134293 cites W1978274834 @default.
- W4324134293 cites W1981964968 @default.
- W4324134293 cites W1983814182 @default.
- W4324134293 cites W1986420295 @default.
- W4324134293 cites W2005036104 @default.
- W4324134293 cites W2013563127 @default.
- W4324134293 cites W2017715011 @default.
- W4324134293 cites W2018105735 @default.
- W4324134293 cites W2020098847 @default.
- W4324134293 cites W2024668613 @default.
- W4324134293 cites W2029584430 @default.
- W4324134293 cites W2031231661 @default.
- W4324134293 cites W2035684015 @default.
- W4324134293 cites W2039851764 @default.
- W4324134293 cites W2041874832 @default.
- W4324134293 cites W2045515542 @default.
- W4324134293 cites W2058446462 @default.
- W4324134293 cites W2061463538 @default.
- W4324134293 cites W2067991812 @default.
- W4324134293 cites W2071263829 @default.
- W4324134293 cites W2071832437 @default.
- W4324134293 cites W2080029391 @default.
- W4324134293 cites W2080270879 @default.
- W4324134293 cites W2084400475 @default.
- W4324134293 cites W2087807630 @default.
- W4324134293 cites W2097948046 @default.
- W4324134293 cites W2108128042 @default.
- W4324134293 cites W2109319321 @default.
- W4324134293 cites W2111075771 @default.
- W4324134293 cites W2112889992 @default.
- W4324134293 cites W2118482957 @default.
- W4324134293 cites W2126525177 @default.
- W4324134293 cites W2129623936 @default.
- W4324134293 cites W2137476611 @default.
- W4324134293 cites W2148945876 @default.
- W4324134293 cites W2159675211 @default.
- W4324134293 cites W2164367561 @default.
- W4324134293 cites W2167279371 @default.
- W4324134293 cites W2169420082 @default.
- W4324134293 cites W2178106250 @default.
- W4324134293 cites W2338669336 @default.
- W4324134293 cites W2406250479 @default.
- W4324134293 cites W2501584383 @default.
- W4324134293 cites W2510426945 @default.
- W4324134293 cites W2515213755 @default.
- W4324134293 cites W2515386838 @default.
- W4324134293 cites W2522057030 @default.
- W4324134293 cites W2563262253 @default.
- W4324134293 cites W2565841756 @default.
- W4324134293 cites W2571047259 @default.
- W4324134293 cites W2582382868 @default.
- W4324134293 cites W2617035720 @default.
- W4324134293 cites W2619342418 @default.
- W4324134293 cites W2623645769 @default.
- W4324134293 cites W2640928612 @default.
- W4324134293 cites W2754543701 @default.
- W4324134293 cites W2755695834 @default.
- W4324134293 cites W2770769467 @default.
- W4324134293 cites W2774690079 @default.
- W4324134293 cites W2791755620 @default.
- W4324134293 cites W2792749026 @default.
- W4324134293 cites W2860743873 @default.
- W4324134293 cites W2910111050 @default.
- W4324134293 cites W2911248861 @default.
- W4324134293 cites W2915823245 @default.
- W4324134293 cites W2919444875 @default.
- W4324134293 cites W2928157366 @default.
- W4324134293 cites W2943781619 @default.
- W4324134293 cites W2965763234 @default.
- W4324134293 cites W3008669596 @default.
- W4324134293 cites W3017075749 @default.
- W4324134293 cites W3044542103 @default.
- W4324134293 cites W3092778820 @default.
- W4324134293 cites W3094515282 @default.
- W4324134293 cites W3097560931 @default.