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- W4324137989 abstract "<h3>Introduction</h3> We aim to showcase the impact of applying self-reported and biomarker-based exposure measures for glyphosate and mancozeb on the association with sleep problems in a study among 253 smallholder farmers in Uganda. <h3>Methods</h3> The questionnaire-based exposure measures included: (1) application days of any pesticide last 7 days (never, 1–2; >2 days) and four glyphosate and mancozeb-specific measures: (2) applicator status last 12 months (yes/no), (3) recent applicator status (never, last 7 days and last 12 months), (4) number of application days last 12 months, (5) average exposure-intensity scores (EIS) derived from a semi-quantitative exposure algorithm and (6) EIS-weighted number of application days in last 12 months. Based on 384 repeatedly collected urinary samples of ETU and glyphosate biomarkers from 85 farmers, we also used (7) estimated biomarker levels. Multivariable logistic regression models to assess the association between the different exposure measures and three selected Medical Outcomes Study Sleep Scale (MOS-SS) indices (6-item sleep inadequacy and snoring) indicate sleep problems in the preceding week. <h3>Results</h3> We observed statistically significant relationships between (1) any pesticide application days in last 7 days and all three sleep problem indices. Glyphosate application in last 7 days (4) and mancozeb application in last 12 months (2) were significantly associated with the 6-item sleep problem index. For the other glyphosate and mancozeb exposure measures based on self-reports, no significant associations were observed. For estimated biomarker levels exposure-response trends pointing in the same direction (p-value < 0.1) with associations with for the 6-item sleep problem index and sleep inadequacy was seen as with the measures based on self-report. <h3>Conclusion</h3> Our results suggest that different pesticide-active ingredient-specific short and long-term exposure measures are relevant when studying the association with (acute) sleep problems." @default.
- W4324137989 created "2023-03-15" @default.
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- W4324137989 date "2023-03-01" @default.
- W4324137989 modified "2023-09-23" @default.
- W4324137989 title "O-306 Performance of self-reported and urinary biomarker-based measures of exposure to glyphosate and mancozeb in a study on sleep problems among smallholder farmers in Uganda" @default.
- W4324137989 doi "https://doi.org/10.1136/oem-2023-epicoh.73" @default.
- W4324137989 hasPublicationYear "2023" @default.
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