Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324138510> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4324138510 endingPage "11" @default.
- W4324138510 startingPage "1" @default.
- W4324138510 abstract "Osteoarthritis (OA) is a chronic musculoskeletal disease affecting approximately 500 million people worldwide. Globally, OA is one of the most common and leading causes of disability. Several genetic factors are involved in OA, including inherited genes, genetic susceptibility, and genetic predisposition. As the pathogenesis of OA is unknown, there are almost no effective treatments available to prevent the onset or progression of the disease. In recent years, many researchers focused on bioinformatics analysis to explore new biomarkers for the diagnosis, treatment, and prognosis of human diseases. In this work, we obtain the traditional RNA sequencing data of OA patients from the GEO database. By performing the differentially expressed analysis, we successfully obtain the genes that are closely associated with the OA. In addition, the Venn diagram was applied to evaluate the genes that are involved in OA and immune-related genes. The protein-protein interaction analysis was further conducted to explore the hub genes. The single-cell RNA sequencing analysis was used to evaluate the expression distribution of the MMP, VEGFA, SPI1, and IRF8 in synovial tissues of patients with osteoarthritis. Finally, the GSVA enrichment analysis discovered the potential pathways involved in OA patients. Our analysis provides a new direction for the exploration of the process of OA patients. In addition, VEGFA may be considered a promising biomarker in OA." @default.
- W4324138510 created "2023-03-15" @default.
- W4324138510 creator A5023536495 @default.
- W4324138510 creator A5062943424 @default.
- W4324138510 creator A5063514061 @default.
- W4324138510 creator A5076967970 @default.
- W4324138510 date "2023-03-14" @default.
- W4324138510 modified "2023-09-25" @default.
- W4324138510 title "The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis" @default.
- W4324138510 cites W131970863 @default.
- W4324138510 cites W2118567612 @default.
- W4324138510 cites W2557275550 @default.
- W4324138510 cites W2804144855 @default.
- W4324138510 cites W2911904736 @default.
- W4324138510 cites W2990114946 @default.
- W4324138510 cites W3001382919 @default.
- W4324138510 cites W3010374200 @default.
- W4324138510 cites W3017870138 @default.
- W4324138510 cites W3023914816 @default.
- W4324138510 cites W3090554329 @default.
- W4324138510 cites W3110294417 @default.
- W4324138510 cites W3166599028 @default.
- W4324138510 cites W3175782279 @default.
- W4324138510 cites W3200982465 @default.
- W4324138510 cites W3203022039 @default.
- W4324138510 cites W4200330806 @default.
- W4324138510 cites W4200520498 @default.
- W4324138510 cites W4210254819 @default.
- W4324138510 cites W4211067786 @default.
- W4324138510 cites W4211069396 @default.
- W4324138510 cites W4212861037 @default.
- W4324138510 cites W4224235728 @default.
- W4324138510 cites W4239968927 @default.
- W4324138510 cites W4241086090 @default.
- W4324138510 cites W4247623962 @default.
- W4324138510 cites W4250827268 @default.
- W4324138510 cites W4307778567 @default.
- W4324138510 cites W4308181113 @default.
- W4324138510 cites W4311855711 @default.
- W4324138510 doi "https://doi.org/10.1155/2023/5574636" @default.
- W4324138510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36960385" @default.
- W4324138510 hasPublicationYear "2023" @default.
- W4324138510 type Work @default.
- W4324138510 citedByCount "0" @default.
- W4324138510 crossrefType "journal-article" @default.
- W4324138510 hasAuthorship W4324138510A5023536495 @default.
- W4324138510 hasAuthorship W4324138510A5062943424 @default.
- W4324138510 hasAuthorship W4324138510A5063514061 @default.
- W4324138510 hasAuthorship W4324138510A5076967970 @default.
- W4324138510 hasBestOaLocation W43241385101 @default.
- W4324138510 hasConcept C104317684 @default.
- W4324138510 hasConcept C126322002 @default.
- W4324138510 hasConcept C142724271 @default.
- W4324138510 hasConcept C150194340 @default.
- W4324138510 hasConcept C204787440 @default.
- W4324138510 hasConcept C2776164576 @default.
- W4324138510 hasConcept C2779134260 @default.
- W4324138510 hasConcept C2781197716 @default.
- W4324138510 hasConcept C54355233 @default.
- W4324138510 hasConcept C60644358 @default.
- W4324138510 hasConcept C70721500 @default.
- W4324138510 hasConcept C71924100 @default.
- W4324138510 hasConcept C8415881 @default.
- W4324138510 hasConcept C86803240 @default.
- W4324138510 hasConceptScore W4324138510C104317684 @default.
- W4324138510 hasConceptScore W4324138510C126322002 @default.
- W4324138510 hasConceptScore W4324138510C142724271 @default.
- W4324138510 hasConceptScore W4324138510C150194340 @default.
- W4324138510 hasConceptScore W4324138510C204787440 @default.
- W4324138510 hasConceptScore W4324138510C2776164576 @default.
- W4324138510 hasConceptScore W4324138510C2779134260 @default.
- W4324138510 hasConceptScore W4324138510C2781197716 @default.
- W4324138510 hasConceptScore W4324138510C54355233 @default.
- W4324138510 hasConceptScore W4324138510C60644358 @default.
- W4324138510 hasConceptScore W4324138510C70721500 @default.
- W4324138510 hasConceptScore W4324138510C71924100 @default.
- W4324138510 hasConceptScore W4324138510C8415881 @default.
- W4324138510 hasConceptScore W4324138510C86803240 @default.
- W4324138510 hasLocation W43241385101 @default.
- W4324138510 hasLocation W43241385102 @default.
- W4324138510 hasLocation W43241385103 @default.
- W4324138510 hasOpenAccess W4324138510 @default.
- W4324138510 hasPrimaryLocation W43241385101 @default.
- W4324138510 hasRelatedWork W1804307181 @default.
- W4324138510 hasRelatedWork W1852689554 @default.
- W4324138510 hasRelatedWork W2021800922 @default.
- W4324138510 hasRelatedWork W2023863442 @default.
- W4324138510 hasRelatedWork W2055853155 @default.
- W4324138510 hasRelatedWork W2096946805 @default.
- W4324138510 hasRelatedWork W2115644765 @default.
- W4324138510 hasRelatedWork W3042917837 @default.
- W4324138510 hasRelatedWork W3204291344 @default.
- W4324138510 hasRelatedWork W4285549808 @default.
- W4324138510 hasVolume "2023" @default.
- W4324138510 isParatext "false" @default.
- W4324138510 isRetracted "false" @default.
- W4324138510 workType "article" @default.