Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324140100> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4324140100 abstract "Background: Understanding the genetic contribution to food choices and intake is critical for the development of effective precision nutrition guidance. Recent findings by our lab suggest that genetic variants (SNPs) related to bitter and umami taste perception are differentially associated with food group intakes. The aim of this study was to examine the associations of bitter- and umami-related SNPs, combined as polygenic taste scores, with overall dietary patterns. Methods: Cross-sectional analyses were conducted in 5,817 Framingham Heart Study Offspring (1998-2001) and Third Generation (2002-05) participants (mean age ± SD: 50 ± 14 years; 54% female). Weighed polygenic taste scores were derived using SNPs identified from prior genome-wide association studies for taste perception (11 SNPs: 9 bitter and 2 umami). Higher scores indicated more alleles for higher taste perception. Empirical dietary patterns were derived using Principal Component (PC) analysis with food groups tabulated from food frequency questionnaires. Associations were assessed using linear mixed effects models with FDR adjustment. Results: Three dietary patterns were identified, explaining 32% of total variance in dietary intake: a vegetables, fruits, legumes, and fish pattern (Prudent); a refined grains, sweets, salty foods, and pizza pattern (Western); and a liquor, beer, and wine pattern (Alcohol). On average, after adjusting for age, sex, genetic PCs and energy intake, higher umami polygenic taste scores were associated with lower adherence to the Prudent dietary pattern (OR [95% CI] for upper vs. lower tertial of dietary pattern adherence scores per additional allele for higher umami perception: 0.87 [0.79, 0.97]; P = 0.01). Subsequent analysis at the SNP-level identified one umami-related SNP (rs7691456_T) independently associated with lower Prudent dietary pattern adherence ( P = 0.009), potentially driving the observed association. Both associations remained significant after additional adjustment for smoking, physical activity, and BMI. No significant associations were identified for bitter-related genes and dietary patterns. Conclusions: Among community dwelling adults, higher genetic predisposition to perceive umami was associated with lower adherence to a Prudent dietary pattern, suggesting the potential benefit of leveraging knowledge of taste-related genes in precision nutrition." @default.
- W4324140100 created "2023-03-15" @default.
- W4324140100 creator A5024775998 @default.
- W4324140100 creator A5034801976 @default.
- W4324140100 creator A5045275171 @default.
- W4324140100 creator A5087239434 @default.
- W4324140100 date "2023-02-28" @default.
- W4324140100 modified "2023-10-16" @default.
- W4324140100 title "Abstract P424: Associations of Taste-Related Genes With Empirical Dietary Patterns Among Community-Dwelling Adults - The Framingham Heart Study" @default.
- W4324140100 doi "https://doi.org/10.1161/circ.147.suppl_1.p424" @default.
- W4324140100 hasPublicationYear "2023" @default.
- W4324140100 type Work @default.
- W4324140100 citedByCount "0" @default.
- W4324140100 crossrefType "journal-article" @default.
- W4324140100 hasAuthorship W4324140100A5024775998 @default.
- W4324140100 hasAuthorship W4324140100A5034801976 @default.
- W4324140100 hasAuthorship W4324140100A5045275171 @default.
- W4324140100 hasAuthorship W4324140100A5087239434 @default.
- W4324140100 hasConcept C104317684 @default.
- W4324140100 hasConcept C111815664 @default.
- W4324140100 hasConcept C11783203 @default.
- W4324140100 hasConcept C126322002 @default.
- W4324140100 hasConcept C135763542 @default.
- W4324140100 hasConcept C153209595 @default.
- W4324140100 hasConcept C2776946002 @default.
- W4324140100 hasConcept C2779134260 @default.
- W4324140100 hasConcept C31903555 @default.
- W4324140100 hasConcept C54355233 @default.
- W4324140100 hasConcept C71924100 @default.
- W4324140100 hasConcept C86803240 @default.
- W4324140100 hasConcept C8868529 @default.
- W4324140100 hasConceptScore W4324140100C104317684 @default.
- W4324140100 hasConceptScore W4324140100C111815664 @default.
- W4324140100 hasConceptScore W4324140100C11783203 @default.
- W4324140100 hasConceptScore W4324140100C126322002 @default.
- W4324140100 hasConceptScore W4324140100C135763542 @default.
- W4324140100 hasConceptScore W4324140100C153209595 @default.
- W4324140100 hasConceptScore W4324140100C2776946002 @default.
- W4324140100 hasConceptScore W4324140100C2779134260 @default.
- W4324140100 hasConceptScore W4324140100C31903555 @default.
- W4324140100 hasConceptScore W4324140100C54355233 @default.
- W4324140100 hasConceptScore W4324140100C71924100 @default.
- W4324140100 hasConceptScore W4324140100C86803240 @default.
- W4324140100 hasConceptScore W4324140100C8868529 @default.
- W4324140100 hasIssue "Suppl_1" @default.
- W4324140100 hasLocation W43241401001 @default.
- W4324140100 hasOpenAccess W4324140100 @default.
- W4324140100 hasPrimaryLocation W43241401001 @default.
- W4324140100 hasRelatedWork W1841517239 @default.
- W4324140100 hasRelatedWork W1991513472 @default.
- W4324140100 hasRelatedWork W1995592460 @default.
- W4324140100 hasRelatedWork W2107151868 @default.
- W4324140100 hasRelatedWork W2157403148 @default.
- W4324140100 hasRelatedWork W2179899926 @default.
- W4324140100 hasRelatedWork W3096703032 @default.
- W4324140100 hasRelatedWork W3112791498 @default.
- W4324140100 hasRelatedWork W3217484785 @default.
- W4324140100 hasRelatedWork W4313557332 @default.
- W4324140100 hasVolume "147" @default.
- W4324140100 isParatext "false" @default.
- W4324140100 isRetracted "false" @default.
- W4324140100 workType "article" @default.