Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324140197> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4324140197 abstract "Background: Most physiopathological mechanisms underlying Blood Pressure (BP) Variability (BPV) are implicated in aging. Vascular aging is associated with chronic low-grade inflammation occurring in late life, known as inflammaging, and the hallmark “mitochondrial dysfunction” due to age-related stress. We aimed to determine whether plasma levels of the pleiotropic stress-related mitokine Growth/Differentiation Factor 15 (GDF-15) and two inflammatory biomarkers, Interleukin 6 (IL-6) and Tumor necrosis factor receptor 1 (TNFR-1), are associated with visit-to-visit BPV in a population of community-dwelling older adults. Methods: The study population consisted of 1,096 community-dwelling participants [median age 75 (72-78) years; 699 females, 63.7%] aged ≥70 years from the MAPT study. Plasma blood sample was collected 12 months after enrolment and BP was assessed up to seven times over a 4-year period. Systolic (SBPV) and diastolic BPV (DBPV) were determined through several indicators taking into account BP change over time, the order of measurements and formulas independent of mean BP levels. Results: Higher values of GDF-15 were significantly associated with increased SBPV (all indicators) after adjustment for relevant covariates [adjusted 1-SD increase in GDF-15: β (SE)= 0.07 (0.04), p< 0.044, for Coefficient of Variation%]. GDF-15 levels were not associated with DBPV. No significant associations were found between IL-6 and BPV, whereas TNFR1 was only partially related to DBPV. Conclusion: Unlike inflammation biomarkers, higher GDF-15 levels were associated with greater SBPV. Our findings support the age-related process of mitochondrial dysfunction underlying BP instability, suggesting that BPV might be a potential marker of aging." @default.
- W4324140197 created "2023-03-15" @default.
- W4324140197 creator A5029122064 @default.
- W4324140197 creator A5031617464 @default.
- W4324140197 creator A5035137483 @default.
- W4324140197 creator A5036845612 @default.
- W4324140197 creator A5049484291 @default.
- W4324140197 creator A5059644192 @default.
- W4324140197 creator A5074314866 @default.
- W4324140197 date "2023-02-28" @default.
- W4324140197 modified "2023-10-16" @default.
- W4324140197 title "Abstract P309: Biomarkers of Mitochondrial Dysfunction and Inflammaging in Older Adults and Blood Pressure Variability" @default.
- W4324140197 doi "https://doi.org/10.1161/circ.147.suppl_1.p309" @default.
- W4324140197 hasPublicationYear "2023" @default.
- W4324140197 type Work @default.
- W4324140197 citedByCount "0" @default.
- W4324140197 crossrefType "journal-article" @default.
- W4324140197 hasAuthorship W4324140197A5029122064 @default.
- W4324140197 hasAuthorship W4324140197A5031617464 @default.
- W4324140197 hasAuthorship W4324140197A5035137483 @default.
- W4324140197 hasAuthorship W4324140197A5036845612 @default.
- W4324140197 hasAuthorship W4324140197A5049484291 @default.
- W4324140197 hasAuthorship W4324140197A5059644192 @default.
- W4324140197 hasAuthorship W4324140197A5074314866 @default.
- W4324140197 hasConcept C126322002 @default.
- W4324140197 hasConcept C134018914 @default.
- W4324140197 hasConcept C136935669 @default.
- W4324140197 hasConcept C164705383 @default.
- W4324140197 hasConcept C185592680 @default.
- W4324140197 hasConcept C2776914184 @default.
- W4324140197 hasConcept C2781197716 @default.
- W4324140197 hasConcept C2908647359 @default.
- W4324140197 hasConcept C55493867 @default.
- W4324140197 hasConcept C57900726 @default.
- W4324140197 hasConcept C71924100 @default.
- W4324140197 hasConcept C74909509 @default.
- W4324140197 hasConcept C84393581 @default.
- W4324140197 hasConcept C99454951 @default.
- W4324140197 hasConceptScore W4324140197C126322002 @default.
- W4324140197 hasConceptScore W4324140197C134018914 @default.
- W4324140197 hasConceptScore W4324140197C136935669 @default.
- W4324140197 hasConceptScore W4324140197C164705383 @default.
- W4324140197 hasConceptScore W4324140197C185592680 @default.
- W4324140197 hasConceptScore W4324140197C2776914184 @default.
- W4324140197 hasConceptScore W4324140197C2781197716 @default.
- W4324140197 hasConceptScore W4324140197C2908647359 @default.
- W4324140197 hasConceptScore W4324140197C55493867 @default.
- W4324140197 hasConceptScore W4324140197C57900726 @default.
- W4324140197 hasConceptScore W4324140197C71924100 @default.
- W4324140197 hasConceptScore W4324140197C74909509 @default.
- W4324140197 hasConceptScore W4324140197C84393581 @default.
- W4324140197 hasConceptScore W4324140197C99454951 @default.
- W4324140197 hasIssue "Suppl_1" @default.
- W4324140197 hasLocation W43241401971 @default.
- W4324140197 hasOpenAccess W4324140197 @default.
- W4324140197 hasPrimaryLocation W43241401971 @default.
- W4324140197 hasRelatedWork W1966504330 @default.
- W4324140197 hasRelatedWork W1966775726 @default.
- W4324140197 hasRelatedWork W1979139803 @default.
- W4324140197 hasRelatedWork W1991560548 @default.
- W4324140197 hasRelatedWork W2030889776 @default.
- W4324140197 hasRelatedWork W2037631372 @default.
- W4324140197 hasRelatedWork W2040058909 @default.
- W4324140197 hasRelatedWork W2132898409 @default.
- W4324140197 hasRelatedWork W2748952813 @default.
- W4324140197 hasRelatedWork W4249176446 @default.
- W4324140197 hasVolume "147" @default.
- W4324140197 isParatext "false" @default.
- W4324140197 isRetracted "false" @default.
- W4324140197 workType "article" @default.