Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324140565> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4324140565 abstract "Introduction: Cardiovascular disease (CVD) and cancer share risk factors, including smoking and obesity. Indeed, an increased cancer risk was reported among patients with CVD, such as myocardial infarction. Lower extremity peripheral artery disease (PAD) has also been explored in this context, but most previous studies included only Whites, had follow-up <10 years, or did not account for key confounders like smoking. Hypothesis: PAD is independently associated with long-term cancer risk in a bi-racial cohort. Methods: We studied 13,102 ARIC participants without prevalent cancer at visit 1 (1987-89) (mean age 54 [SD 6] years, 54% women, and 26% Black) (funding: NHLBI, NCI, and NPCR). Incident cancer was ascertained by linkage to cancer registries and medical record review. We categorized PAD status at visit 1 into symptomatic PAD (intermittent claudication or a history of lower extremity revascularization), asymptomatic PAD (ankle brachial index [ABI] ≤0.9), and other ABI categories of >0.9-1.0, >1.0-1.1, >1.1-1.2, >1.2-1.3 and >1.3. We ran multivariable Cox models. Results: During the median follow-up of 25 years (IQI 15-27 years), there were 4,142 incident cancer cases. 25-year cumulative cancer incidence was 48% in symptomatic PAD, 39% in asymptomatic PAD, and 31-34% in the other categories. When we adjusted for demographic factors, both symptomatic and asymptomatic PAD showed significant hazard ratios for incident cancer (1.79 [95%CI 1.33-2.43] and 1.39 [1.18-1.63], respectively, vs. ABI 1.1-1.2, Model 1 in Table ). After adjusting for additional potential confounders, including smoking and diabetes, these associations were somewhat attenuated but remained consistent (Models 2-4 in Table ). Conclusion: Both symptomatic and asymptomatic PAD were associated with an increased risk of cancer independently of smoking and diabetes. Although potential mechanisms should be explored, clinicians should be aware of this excess cancer risk among patients with PAD when considering cancer prevention and screening." @default.
- W4324140565 created "2023-03-15" @default.
- W4324140565 creator A5002691316 @default.
- W4324140565 creator A5012125830 @default.
- W4324140565 creator A5021153700 @default.
- W4324140565 creator A5024041740 @default.
- W4324140565 creator A5049891011 @default.
- W4324140565 creator A5053982667 @default.
- W4324140565 creator A5081620371 @default.
- W4324140565 creator A5086558284 @default.
- W4324140565 date "2023-02-28" @default.
- W4324140565 modified "2023-10-16" @default.
- W4324140565 title "Abstract P105: Peripheral Artery Disease and Subsequent Risk of Cancer: The Atherosclerosis Risk in Communities (ARIC) Study" @default.
- W4324140565 doi "https://doi.org/10.1161/circ.147.suppl_1.p105" @default.
- W4324140565 hasPublicationYear "2023" @default.
- W4324140565 type Work @default.
- W4324140565 citedByCount "0" @default.
- W4324140565 crossrefType "journal-article" @default.
- W4324140565 hasAuthorship W4324140565A5002691316 @default.
- W4324140565 hasAuthorship W4324140565A5012125830 @default.
- W4324140565 hasAuthorship W4324140565A5021153700 @default.
- W4324140565 hasAuthorship W4324140565A5024041740 @default.
- W4324140565 hasAuthorship W4324140565A5049891011 @default.
- W4324140565 hasAuthorship W4324140565A5053982667 @default.
- W4324140565 hasAuthorship W4324140565A5081620371 @default.
- W4324140565 hasAuthorship W4324140565A5086558284 @default.
- W4324140565 hasConcept C121608353 @default.
- W4324140565 hasConcept C126322002 @default.
- W4324140565 hasConcept C141071460 @default.
- W4324140565 hasConcept C151730666 @default.
- W4324140565 hasConcept C207103383 @default.
- W4324140565 hasConcept C2777466421 @default.
- W4324140565 hasConcept C2777910003 @default.
- W4324140565 hasConcept C2778963770 @default.
- W4324140565 hasConcept C2779343474 @default.
- W4324140565 hasConcept C2779881954 @default.
- W4324140565 hasConcept C3018348675 @default.
- W4324140565 hasConcept C44249647 @default.
- W4324140565 hasConcept C500558357 @default.
- W4324140565 hasConcept C50382708 @default.
- W4324140565 hasConcept C530470458 @default.
- W4324140565 hasConcept C71924100 @default.
- W4324140565 hasConcept C72563966 @default.
- W4324140565 hasConcept C86803240 @default.
- W4324140565 hasConceptScore W4324140565C121608353 @default.
- W4324140565 hasConceptScore W4324140565C126322002 @default.
- W4324140565 hasConceptScore W4324140565C141071460 @default.
- W4324140565 hasConceptScore W4324140565C151730666 @default.
- W4324140565 hasConceptScore W4324140565C207103383 @default.
- W4324140565 hasConceptScore W4324140565C2777466421 @default.
- W4324140565 hasConceptScore W4324140565C2777910003 @default.
- W4324140565 hasConceptScore W4324140565C2778963770 @default.
- W4324140565 hasConceptScore W4324140565C2779343474 @default.
- W4324140565 hasConceptScore W4324140565C2779881954 @default.
- W4324140565 hasConceptScore W4324140565C3018348675 @default.
- W4324140565 hasConceptScore W4324140565C44249647 @default.
- W4324140565 hasConceptScore W4324140565C500558357 @default.
- W4324140565 hasConceptScore W4324140565C50382708 @default.
- W4324140565 hasConceptScore W4324140565C530470458 @default.
- W4324140565 hasConceptScore W4324140565C71924100 @default.
- W4324140565 hasConceptScore W4324140565C72563966 @default.
- W4324140565 hasConceptScore W4324140565C86803240 @default.
- W4324140565 hasIssue "Suppl_1" @default.
- W4324140565 hasLocation W43241405651 @default.
- W4324140565 hasOpenAccess W4324140565 @default.
- W4324140565 hasPrimaryLocation W43241405651 @default.
- W4324140565 hasRelatedWork W2084177335 @default.
- W4324140565 hasRelatedWork W2139755348 @default.
- W4324140565 hasRelatedWork W2155942116 @default.
- W4324140565 hasRelatedWork W2159339760 @default.
- W4324140565 hasRelatedWork W2175432226 @default.
- W4324140565 hasRelatedWork W2255919260 @default.
- W4324140565 hasRelatedWork W2317558058 @default.
- W4324140565 hasRelatedWork W2461944024 @default.
- W4324140565 hasRelatedWork W2773578431 @default.
- W4324140565 hasRelatedWork W2987985474 @default.
- W4324140565 hasVolume "147" @default.
- W4324140565 isParatext "false" @default.
- W4324140565 isRetracted "false" @default.
- W4324140565 workType "article" @default.