FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324141345> ?p ?o ?g. }

• W4324141345 endingPage "719" @default.
• W4324141345 startingPage "719" @default.
• W4324141345 abstract "Maternal obesity and gestational diabetes mellitus (GDM) are associated with placental dysfunction, small for gestational age (SGA) offspring, and programming of adult-onset disease. We examine how metformin, commonly used to treat type A2 GDM, affects placental metabolism as well as mitochondrial content and function. Syncytiotrophoblasts (STBs) were prepared from placentas of male and female fetuses collected at term cesarean section from lean (pre-pregnancy BMI < 25), obese (BMI > 30), and obese A2GDM women. Metformin treatment (0.001–10 mM) of STB caused no change in non-mitochondrial respiration but significant concentration-dependent (1 and 10 mM) decreases in basal, maximal, and ATP-linked respiration and spare capacity. Respiration linked to proton leak was significantly increased in STB of male A2GDM placentas at low metformin concentrations. Metformin concentrations ≥1 mM increased glycolysis in STB from placentas from lean women, but only improved glycolytic capacity in female STB. Whereas metformin had little effect on superoxide generation from male STB of any group, it gave a concentration-dependent decrease in superoxide generation from female STB of lean and obese women. Fewer mitochondria were observed in STB from obese women and male STB from lean women with increasing metformin concentration. Metformin affects STB mitochondrial function in a sexually dimorphic manner but at concentrations above those reported in maternal circulation (approximately 0.01 mM) in women treated with metformin for GDM." @default.
• W4324141345 created "2023-03-15" @default.
• W4324141345 creator A5048209900 @default.
• W4324141345 creator A5080085788 @default.
• W4324141345 date "2023-03-14" @default.
• W4324141345 modified "2023-10-05" @default.
• W4324141345 title "Metformin Impacts Human Syncytiotrophoblast Mitochondrial Function from Pregnancies Complicated by Obesity and Gestational Diabetes Mellitus in a Sexually Dimorphic Manner" @default.
• W4324141345 cites W1001416930 @default.
• W4324141345 cites W1480999133 @default.
• W4324141345 cites W1867360977 @default.
• W4324141345 cites W1974864674 @default.
• W4324141345 cites W1975136933 @default.
• W4324141345 cites W1982172078 @default.
• W4324141345 cites W1982179528 @default.
• W4324141345 cites W1987971119 @default.
• W4324141345 cites W2001340600 @default.
• W4324141345 cites W2012442095 @default.
• W4324141345 cites W2015455880 @default.
• W4324141345 cites W2015587326 @default.
• W4324141345 cites W2015838103 @default.
• W4324141345 cites W2021362162 @default.
• W4324141345 cites W2022952278 @default.
• W4324141345 cites W2029402131 @default.
• W4324141345 cites W2032337062 @default.
• W4324141345 cites W2042257536 @default.
• W4324141345 cites W2051328227 @default.
• W4324141345 cites W2060301363 @default.
• W4324141345 cites W2063226778 @default.
• W4324141345 cites W2076366658 @default.
• W4324141345 cites W2094191679 @default.
• W4324141345 cites W2102108110 @default.
• W4324141345 cites W2103467021 @default.
• W4324141345 cites W2113909175 @default.
• W4324141345 cites W2127155727 @default.
• W4324141345 cites W2141573143 @default.
• W4324141345 cites W2144903426 @default.
• W4324141345 cites W2154024784 @default.
• W4324141345 cites W2283295755 @default.
• W4324141345 cites W2325770675 @default.
• W4324141345 cites W2566620777 @default.
• W4324141345 cites W2583451438 @default.
• W4324141345 cites W2617303046 @default.
• W4324141345 cites W2622627400 @default.
• W4324141345 cites W263203584 @default.
• W4324141345 cites W2739928654 @default.
• W4324141345 cites W2779177525 @default.
• W4324141345 cites W2795985395 @default.
• W4324141345 cites W2889492693 @default.
• W4324141345 cites W2904715359 @default.
• W4324141345 cites W2945573736 @default.
• W4324141345 cites W2970771292 @default.
• W4324141345 cites W2991495657 @default.
• W4324141345 cites W3001284540 @default.
• W4324141345 cites W3010682058 @default.
• W4324141345 cites W3176437736 @default.
• W4324141345 cites W3206418208 @default.
• W4324141345 cites W4245594583 @default.
• W4324141345 cites W4283066775 @default.
• W4324141345 cites W4283723802 @default.
• W4324141345 cites W59444844 @default.
• W4324141345 doi "https://doi.org/10.3390/antiox12030719" @default.
• W4324141345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36978967" @default.
• W4324141345 hasPublicationYear "2023" @default.
• W4324141345 type Work @default.
• W4324141345 citedByCount "1" @default.
• W4324141345 countsByYear W43241413452023 @default.
• W4324141345 crossrefType "journal-article" @default.
• W4324141345 hasAuthorship W4324141345A5048209900 @default.
• W4324141345 hasAuthorship W4324141345A5080085788 @default.
• W4324141345 hasBestOaLocation W43241413451 @default.
• W4324141345 hasConcept C112672928 @default.
• W4324141345 hasConcept C126322002 @default.
• W4324141345 hasConcept C134018914 @default.
• W4324141345 hasConcept C172680121 @default.
• W4324141345 hasConcept C2776953305 @default.
• W4324141345 hasConcept C2779234561 @default.
• W4324141345 hasConcept C2779315647 @default.
• W4324141345 hasConcept C2779434492 @default.
• W4324141345 hasConcept C2780323712 @default.
• W4324141345 hasConcept C28859421 @default.
• W4324141345 hasConcept C46973012 @default.
• W4324141345 hasConcept C54355233 @default.
• W4324141345 hasConcept C555293320 @default.
• W4324141345 hasConcept C71924100 @default.
• W4324141345 hasConcept C86803240 @default.
• W4324141345 hasConcept C95444343 @default.
• W4324141345 hasConceptScore W4324141345C112672928 @default.
• W4324141345 hasConceptScore W4324141345C126322002 @default.
• W4324141345 hasConceptScore W4324141345C134018914 @default.
• W4324141345 hasConceptScore W4324141345C172680121 @default.
• W4324141345 hasConceptScore W4324141345C2776953305 @default.
• W4324141345 hasConceptScore W4324141345C2779234561 @default.
• W4324141345 hasConceptScore W4324141345C2779315647 @default.
• W4324141345 hasConceptScore W4324141345C2779434492 @default.
• W4324141345 hasConceptScore W4324141345C2780323712 @default.
• W4324141345 hasConceptScore W4324141345C28859421 @default.
• W4324141345 hasConceptScore W4324141345C46973012 @default.
• W4324141345 hasConceptScore W4324141345C54355233 @default.

• next