Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324141581> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4324141581 endingPage "S57" @default.
- W4324141581 startingPage "S56" @default.
- W4324141581 abstract "Purpose: No disease modifying osteoarthritis (OA) treatment is presently available. Such lack depends also on the absence of relevant preclinical in vitro models to dissect the pathogenesis mechanisms and screen potential disease modifying compounds. OA leads to cartilage degeneration but also to hypertrophic cartilage vascular invasion and subchondral bone sclerosis. All the tissues of the osteochondral unit (Fig.1a) are affected. Moreover, while OA is recognized as a complex multi-etiological pathology, it seems to have a correlation with mechanical risk factors such as joint misalignment, obesity, and trauma. Mechanical stimuli and inter-tissues crosstalk are therefore of paramount importance in developing suitable OA models. In this work we propose a new mechanically active Organ-on-Chip (OoC) that allows for the generation of stacked, directly interfaced, 3D multi-tissue microconstructs. Leveraging on this technology we pioneered a new joint OoC where both a cartilage and a (vascularized) subchondral compartment are introduced in the same mechanically active OoC and subjected to discrete compression levels." @default.
- W4324141581 created "2023-03-15" @default.
- W4324141581 creator A5009041376 @default.
- W4324141581 creator A5023868924 @default.
- W4324141581 creator A5035121213 @default.
- W4324141581 creator A5037476957 @default.
- W4324141581 creator A5084036940 @default.
- W4324141581 date "2023-03-01" @default.
- W4324141581 modified "2023-10-16" @default.
- W4324141581 title "Towards Modelling The Joint On A Chip: A Mechanically Active Microfluidic System Designed For Engineered 3d Multi-Layer Osteochondral Tissues" @default.
- W4324141581 doi "https://doi.org/10.1016/j.joca.2023.01.551" @default.
- W4324141581 hasPublicationYear "2023" @default.
- W4324141581 type Work @default.
- W4324141581 citedByCount "0" @default.
- W4324141581 crossrefType "journal-article" @default.
- W4324141581 hasAuthorship W4324141581A5009041376 @default.
- W4324141581 hasAuthorship W4324141581A5023868924 @default.
- W4324141581 hasAuthorship W4324141581A5035121213 @default.
- W4324141581 hasAuthorship W4324141581A5037476957 @default.
- W4324141581 hasAuthorship W4324141581A5084036940 @default.
- W4324141581 hasConcept C105702510 @default.
- W4324141581 hasConcept C127413603 @default.
- W4324141581 hasConcept C136229726 @default.
- W4324141581 hasConcept C142724271 @default.
- W4324141581 hasConcept C165932988 @default.
- W4324141581 hasConcept C169822122 @default.
- W4324141581 hasConcept C171250308 @default.
- W4324141581 hasConcept C18555067 @default.
- W4324141581 hasConcept C192562407 @default.
- W4324141581 hasConcept C204787440 @default.
- W4324141581 hasConcept C24326235 @default.
- W4324141581 hasConcept C2776164576 @default.
- W4324141581 hasConcept C2780550940 @default.
- W4324141581 hasConcept C2988198817 @default.
- W4324141581 hasConcept C3020332539 @default.
- W4324141581 hasConcept C66938386 @default.
- W4324141581 hasConcept C71924100 @default.
- W4324141581 hasConcept C8673954 @default.
- W4324141581 hasConceptScore W4324141581C105702510 @default.
- W4324141581 hasConceptScore W4324141581C127413603 @default.
- W4324141581 hasConceptScore W4324141581C136229726 @default.
- W4324141581 hasConceptScore W4324141581C142724271 @default.
- W4324141581 hasConceptScore W4324141581C165932988 @default.
- W4324141581 hasConceptScore W4324141581C169822122 @default.
- W4324141581 hasConceptScore W4324141581C171250308 @default.
- W4324141581 hasConceptScore W4324141581C18555067 @default.
- W4324141581 hasConceptScore W4324141581C192562407 @default.
- W4324141581 hasConceptScore W4324141581C204787440 @default.
- W4324141581 hasConceptScore W4324141581C24326235 @default.
- W4324141581 hasConceptScore W4324141581C2776164576 @default.
- W4324141581 hasConceptScore W4324141581C2780550940 @default.
- W4324141581 hasConceptScore W4324141581C2988198817 @default.
- W4324141581 hasConceptScore W4324141581C3020332539 @default.
- W4324141581 hasConceptScore W4324141581C66938386 @default.
- W4324141581 hasConceptScore W4324141581C71924100 @default.
- W4324141581 hasConceptScore W4324141581C8673954 @default.
- W4324141581 hasLocation W43241415811 @default.
- W4324141581 hasOpenAccess W4324141581 @default.
- W4324141581 hasPrimaryLocation W43241415811 @default.
- W4324141581 hasRelatedWork W147982757 @default.
- W4324141581 hasRelatedWork W1968203093 @default.
- W4324141581 hasRelatedWork W1975387610 @default.
- W4324141581 hasRelatedWork W2125062201 @default.
- W4324141581 hasRelatedWork W2354155665 @default.
- W4324141581 hasRelatedWork W2609988931 @default.
- W4324141581 hasRelatedWork W3169383880 @default.
- W4324141581 hasRelatedWork W3197358415 @default.
- W4324141581 hasRelatedWork W4377822991 @default.
- W4324141581 hasRelatedWork W1948538391 @default.
- W4324141581 hasVolume "31" @default.
- W4324141581 isParatext "false" @default.
- W4324141581 isRetracted "false" @default.
- W4324141581 workType "article" @default.