Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324143080> ?p ?o ?g. }
- W4324143080 abstract "The cardiac responses to vagus nerve stimulation (VNS) are still not fully understood, partly due to uncontrollable confounders in the in-vivo experimental condition. Therefore, an ex-vivo Langendorff-perfused rabbit heart with intact vagal innervation is proposed to study VNS in absence of cofounding anesthetic or autonomic influences. The feasibility to evoke chronotropic responses through electrical stimulation ex-vivo was studied in innervated isolated rabbit hearts (n = 6). The general nerve excitability was assessed through the ability to evoke a heart rate (HR) reduction of at least 5 bpm (physiological threshold). The excitability was quantified as the charge needed for a 10-bpm HR reduction. The results were compared to a series of in-vivo experiments rabbits (n = 5). In the ex-vivo isolated heart, the baseline HR was about 20 bpm lower than in-vivo (158 ± 11 bpm vs 181 ± 19 bpm). Overall, the nerve remained excitable for about 5 h ex-vivo. The charges required to reduce HR by 5 bpm were 9 ± 6 µC and 549 ± 370 µC, ex-vivo and in-vivo, respectively. The charges needed for a 10-bpm HR reduction, normalized to the physiological threshold were 1.78 ± 0.8 and 1.22 ± 0.1, in-vivo and ex-vivo, respectively. Overall, the viability of this ex-vivo model to study the acute cardiac effects of VNS was demonstrated." @default.
- W4324143080 created "2023-03-15" @default.
- W4324143080 creator A5017745159 @default.
- W4324143080 creator A5019045279 @default.
- W4324143080 creator A5023649031 @default.
- W4324143080 creator A5031567692 @default.
- W4324143080 creator A5032412323 @default.
- W4324143080 creator A5033286227 @default.
- W4324143080 creator A5066373432 @default.
- W4324143080 creator A5074163836 @default.
- W4324143080 date "2023-03-14" @default.
- W4324143080 modified "2023-10-01" @default.
- W4324143080 title "A novel ex-vivo isolated rabbit heart preparation to explore the cardiac effects of cervical and cardiac vagus nerve stimulation" @default.
- W4324143080 cites W137883775 @default.
- W4324143080 cites W1572240952 @default.
- W4324143080 cites W1965019913 @default.
- W4324143080 cites W2021060449 @default.
- W4324143080 cites W2049157075 @default.
- W4324143080 cites W2057373458 @default.
- W4324143080 cites W2069421580 @default.
- W4324143080 cites W2109454934 @default.
- W4324143080 cites W2116095873 @default.
- W4324143080 cites W2125741523 @default.
- W4324143080 cites W2132378912 @default.
- W4324143080 cites W2140259596 @default.
- W4324143080 cites W2148936486 @default.
- W4324143080 cites W2153526423 @default.
- W4324143080 cites W2162242381 @default.
- W4324143080 cites W2167526183 @default.
- W4324143080 cites W2188371413 @default.
- W4324143080 cites W2254718226 @default.
- W4324143080 cites W2330907269 @default.
- W4324143080 cites W2337818477 @default.
- W4324143080 cites W2418361957 @default.
- W4324143080 cites W2468671092 @default.
- W4324143080 cites W2469268362 @default.
- W4324143080 cites W2525609606 @default.
- W4324143080 cites W2547640861 @default.
- W4324143080 cites W2734785884 @default.
- W4324143080 cites W2763016572 @default.
- W4324143080 cites W2788012462 @default.
- W4324143080 cites W2793022702 @default.
- W4324143080 cites W2794294466 @default.
- W4324143080 cites W2797370520 @default.
- W4324143080 cites W2802298694 @default.
- W4324143080 cites W2802441760 @default.
- W4324143080 cites W2804635995 @default.
- W4324143080 cites W2898558190 @default.
- W4324143080 cites W2955659808 @default.
- W4324143080 cites W2995112370 @default.
- W4324143080 cites W3002075194 @default.
- W4324143080 cites W3004330907 @default.
- W4324143080 cites W3007271119 @default.
- W4324143080 cites W3011971328 @default.
- W4324143080 cites W3036758132 @default.
- W4324143080 cites W3089073800 @default.
- W4324143080 cites W3124358928 @default.
- W4324143080 cites W3131160888 @default.
- W4324143080 cites W3160812254 @default.
- W4324143080 cites W3163010857 @default.
- W4324143080 cites W3163344635 @default.
- W4324143080 cites W3165126057 @default.
- W4324143080 cites W3202004322 @default.
- W4324143080 cites W3209838526 @default.
- W4324143080 cites W3210918237 @default.
- W4324143080 cites W34365074 @default.
- W4324143080 cites W4213216035 @default.
- W4324143080 cites W4214687512 @default.
- W4324143080 cites W4220955255 @default.
- W4324143080 cites W4225491235 @default.
- W4324143080 cites W4281649449 @default.
- W4324143080 cites W4285741601 @default.
- W4324143080 cites W4295233308 @default.
- W4324143080 cites W4308261754 @default.
- W4324143080 doi "https://doi.org/10.1038/s41598-023-31135-4" @default.
- W4324143080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36918673" @default.
- W4324143080 hasPublicationYear "2023" @default.
- W4324143080 type Work @default.
- W4324143080 citedByCount "0" @default.
- W4324143080 crossrefType "journal-article" @default.
- W4324143080 hasAuthorship W4324143080A5017745159 @default.
- W4324143080 hasAuthorship W4324143080A5019045279 @default.
- W4324143080 hasAuthorship W4324143080A5023649031 @default.
- W4324143080 hasAuthorship W4324143080A5031567692 @default.
- W4324143080 hasAuthorship W4324143080A5032412323 @default.
- W4324143080 hasAuthorship W4324143080A5033286227 @default.
- W4324143080 hasAuthorship W4324143080A5066373432 @default.
- W4324143080 hasAuthorship W4324143080A5074163836 @default.
- W4324143080 hasBestOaLocation W43241430801 @default.
- W4324143080 hasConcept C126322002 @default.
- W4324143080 hasConcept C150903083 @default.
- W4324143080 hasConcept C158328960 @default.
- W4324143080 hasConcept C207001950 @default.
- W4324143080 hasConcept C24998067 @default.
- W4324143080 hasConcept C26291073 @default.
- W4324143080 hasConcept C2777372248 @default.
- W4324143080 hasConcept C2777953023 @default.
- W4324143080 hasConcept C2780087125 @default.
- W4324143080 hasConcept C2780761756 @default.
- W4324143080 hasConcept C2781404750 @default.