FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324143314> ?p ?o ?g. }

• W4324143314 endingPage "147" @default.
• W4324143314 startingPage "137" @default.
• W4324143314 abstract "The targeting of transforming growth factor β (TGF-β) has been shown to reduce complications related to ischemia-reperfusion injury (IRI) post-surgically. Pirfenidone (PFD) specifically inhibits TGF-β expression and has been demonstrated to provide protection from IRI in short-term allograft models, though not yet in long-term models. A chronic unilateral IRI model was established using male Wistar rats. The animals were divided into two groups: one with IRI and a pre-treatment of PFD (0.5 mg/kg) followed by 0.5 mg/kg/day of orally administered PFD for 30 days, and a control group without PFD treatment. A sham group was also included. Kidneys and blood samples were collected after 30 days, and the renal function was evaluated by measuring the serum creatinine and KIM-1 levels. RT-PCR was used to analyze fibrosis-related genes, and Luminex to quantify the pro-inflammatory serum IL-18 cytokine. Renal section staining and histological analysis were used to detect collagen deposits. Comparison within the groups showed an increase in serum creatinine and KIM-1 expression after IRI in the control group, while PFD reduced COLL1A1 and TGF-β expression and demonstrated a reduction in fibrosis through histological stains. The treatment group also showed a reduction in IL-18. Our results suggest that PFD exerts protective effects on chronic renal IRI, reducing fibrosis development and inflammation. This study provides new insights into the treatment and management of chronic renal function loss after IRI." @default.
• W4324143314 created "2023-03-15" @default.
• W4324143314 creator A5010684548 @default.
• W4324143314 creator A5012980181 @default.
• W4324143314 creator A5030128779 @default.
• W4324143314 creator A5035532611 @default.
• W4324143314 creator A5040222370 @default.
• W4324143314 creator A5048319729 @default.
• W4324143314 creator A5050028912 @default.
• W4324143314 creator A5067289859 @default.
• W4324143314 creator A5067662773 @default.
• W4324143314 creator A5075830669 @default.
• W4324143314 creator A5079809567 @default.
• W4324143314 creator A5090784415 @default.
• W4324143314 creator A5091638332 @default.
• W4324143314 date "2023-03-13" @default.
• W4324143314 modified "2023-10-17" @default.
• W4324143314 title "Pharmacological Blockade of TGF-Beta Reduces Renal Interstitial Fibrosis in a Chronic Ischemia–Reperfusion Animal Model" @default.
• W4324143314 cites W1971799714 @default.
• W4324143314 cites W2009729476 @default.
• W4324143314 cites W2025562293 @default.
• W4324143314 cites W2031384622 @default.
• W4324143314 cites W2060112842 @default.
• W4324143314 cites W2085604666 @default.
• W4324143314 cites W2091897235 @default.
• W4324143314 cites W2135344591 @default.
• W4324143314 cites W2135863640 @default.
• W4324143314 cites W2143633302 @default.
• W4324143314 cites W2144841649 @default.
• W4324143314 cites W2156699931 @default.
• W4324143314 cites W2171324990 @default.
• W4324143314 cites W2342679639 @default.
• W4324143314 cites W2407574550 @default.
• W4324143314 cites W2521123529 @default.
• W4324143314 cites W2743483389 @default.
• W4324143314 cites W2783611541 @default.
• W4324143314 cites W2792968897 @default.
• W4324143314 cites W2888812846 @default.
• W4324143314 cites W2940874449 @default.
• W4324143314 cites W2944885979 @default.
• W4324143314 cites W2947507420 @default.
• W4324143314 cites W2958875938 @default.
• W4324143314 cites W2969740004 @default.
• W4324143314 cites W3007757041 @default.
• W4324143314 cites W3040621916 @default.
• W4324143314 cites W3101309787 @default.
• W4324143314 cites W4230399767 @default.
• W4324143314 cites W4294677238 @default.
• W4324143314 cites W4302773369 @default.
• W4324143314 cites W4310191078 @default.
• W4324143314 doi "https://doi.org/10.3390/ddc2010009" @default.
• W4324143314 hasPublicationYear "2023" @default.
• W4324143314 type Work @default.
• W4324143314 citedByCount "1" @default.
• W4324143314 countsByYear W43241433142023 @default.
• W4324143314 crossrefType "journal-article" @default.
• W4324143314 hasAuthorship W4324143314A5010684548 @default.
• W4324143314 hasAuthorship W4324143314A5012980181 @default.
• W4324143314 hasAuthorship W4324143314A5030128779 @default.
• W4324143314 hasAuthorship W4324143314A5035532611 @default.
• W4324143314 hasAuthorship W4324143314A5040222370 @default.
• W4324143314 hasAuthorship W4324143314A5048319729 @default.
• W4324143314 hasAuthorship W4324143314A5050028912 @default.
• W4324143314 hasAuthorship W4324143314A5067289859 @default.
• W4324143314 hasAuthorship W4324143314A5067662773 @default.
• W4324143314 hasAuthorship W4324143314A5075830669 @default.
• W4324143314 hasAuthorship W4324143314A5079809567 @default.
• W4324143314 hasAuthorship W4324143314A5090784415 @default.
• W4324143314 hasAuthorship W4324143314A5091638332 @default.
• W4324143314 hasBestOaLocation W43241433141 @default.
• W4324143314 hasConcept C118131993 @default.
• W4324143314 hasConcept C126322002 @default.
• W4324143314 hasConcept C126894567 @default.
• W4324143314 hasConcept C159641895 @default.
• W4324143314 hasConcept C2776914184 @default.
• W4324143314 hasConcept C2777714996 @default.
• W4324143314 hasConcept C2778229498 @default.
• W4324143314 hasConcept C2778341716 @default.
• W4324143314 hasConcept C2778690821 @default.
• W4324143314 hasConcept C2779832356 @default.
• W4324143314 hasConcept C2780091579 @default.
• W4324143314 hasConcept C2780114680 @default.
• W4324143314 hasConcept C2780306776 @default.
• W4324143314 hasConcept C2780559512 @default.
• W4324143314 hasConcept C541997718 @default.
• W4324143314 hasConcept C71924100 @default.
• W4324143314 hasConceptScore W4324143314C118131993 @default.
• W4324143314 hasConceptScore W4324143314C126322002 @default.
• W4324143314 hasConceptScore W4324143314C126894567 @default.
• W4324143314 hasConceptScore W4324143314C159641895 @default.
• W4324143314 hasConceptScore W4324143314C2776914184 @default.
• W4324143314 hasConceptScore W4324143314C2777714996 @default.
• W4324143314 hasConceptScore W4324143314C2778229498 @default.
• W4324143314 hasConceptScore W4324143314C2778341716 @default.
• W4324143314 hasConceptScore W4324143314C2778690821 @default.
• W4324143314 hasConceptScore W4324143314C2779832356 @default.
• W4324143314 hasConceptScore W4324143314C2780091579 @default.
• W4324143314 hasConceptScore W4324143314C2780114680 @default.

• next