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- W4324143752 abstract "Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like molecule, shares many of the interactive properties of HS. The aim of this review was to outline the potential of PPS as an interventional therapeutic protective agent in physiological processes affecting pathological tissues. PPS is a multifunctional molecule with diverse therapeutic actions against many disease processes. PPS has been used for decades in the treatment of interstitial cystitis and painful bowel disease, it has tissue-protective properties as a protease inhibitor in cartilage, tendon and IVD, and it has been used as a cell-directive component in bioscaffolds in tissue engineering applications. PPS regulates complement activation, coagulation, fibrinolysis and thrombocytopenia, and it promotes the synthesis of hyaluronan. Nerve growth factor production in osteocytes is inhibited by PPS, reducing bone pain in osteoarthritis and rheumatoid arthritis (OA/RA). PPS also removes fatty compounds from lipid-engorged subchondral blood vessels in OA/RA cartilage, reducing joint pain. PPS regulates cytokine and inflammatory mediator production and is also an anti-tumor agent that promotes the proliferation and differentiation of mesenchymal stem cells and the development of progenitor cell lineages that have proven to be useful in strategies designed to effect repair of the degenerate intervertebral disc (IVD) and OA cartilage. PPS stimulates proteoglycan synthesis by chondrocytes in the presence or absence of interleukin (IL)-1, and stimulates hyaluronan production by synoviocytes. PPS is thus a multifunctional tissue-protective molecule of potential therapeutic application for a diverse range of disease processes." @default.
- W4324143752 created "2023-03-15" @default.
- W4324143752 creator A5076112559 @default.
- W4324143752 creator A5085683052 @default.
- W4324143752 date "2023-03-13" @default.
- W4324143752 modified "2023-10-01" @default.
- W4324143752 title "Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues" @default.
- W4324143752 cites W142299751 @default.
- W4324143752 cites W1483299144 @default.
- W4324143752 cites W1485642143 @default.
- W4324143752 cites W1491058197 @default.
- W4324143752 cites W1492004984 @default.
- W4324143752 cites W1511115228 @default.
- W4324143752 cites W1514428065 @default.
- W4324143752 cites W1517316308 @default.
- W4324143752 cites W1525773789 @default.
- W4324143752 cites W1529163766 @default.
- W4324143752 cites W1554088208 @default.
- W4324143752 cites W1592322583 @default.
- W4324143752 cites W1599896611 @default.
- W4324143752 cites W1601007012 @default.
- W4324143752 cites W1606989141 @default.
- W4324143752 cites W1610161427 @default.
- W4324143752 cites W1817454614 @default.
- W4324143752 cites W1904256453 @default.
- W4324143752 cites W1919363330 @default.
- W4324143752 cites W1965671620 @default.
- W4324143752 cites W1967255523 @default.
- W4324143752 cites W1968249815 @default.
- W4324143752 cites W1968297376 @default.
- W4324143752 cites W1971761285 @default.
- W4324143752 cites W1972195970 @default.
- W4324143752 cites W1974403367 @default.
- W4324143752 cites W1974927907 @default.
- W4324143752 cites W1978284271 @default.
- W4324143752 cites W1978435105 @default.
- W4324143752 cites W1981386040 @default.
- W4324143752 cites W1981399912 @default.
- W4324143752 cites W1982443445 @default.
- W4324143752 cites W1983454661 @default.
- W4324143752 cites W1985156103 @default.
- W4324143752 cites W1987063873 @default.
- W4324143752 cites W1987373627 @default.
- W4324143752 cites W1989287762 @default.
- W4324143752 cites W1991509224 @default.
- W4324143752 cites W1991885630 @default.
- W4324143752 cites W1992773224 @default.
- W4324143752 cites W1994436843 @default.
- W4324143752 cites W1994940043 @default.
- W4324143752 cites W1995259468 @default.
- W4324143752 cites W1996355608 @default.
- W4324143752 cites W1996388240 @default.
- W4324143752 cites W1996849683 @default.
- W4324143752 cites W1998346532 @default.
- W4324143752 cites W1998350370 @default.
- W4324143752 cites W1998721553 @default.
- W4324143752 cites W1999040528 @default.
- W4324143752 cites W2000124550 @default.
- W4324143752 cites W2000241544 @default.
- W4324143752 cites W2001054380 @default.
- W4324143752 cites W2002986410 @default.
- W4324143752 cites W2004632028 @default.
- W4324143752 cites W2007505738 @default.
- W4324143752 cites W2008383971 @default.
- W4324143752 cites W2008738075 @default.
- W4324143752 cites W2008808264 @default.
- W4324143752 cites W2011540524 @default.
- W4324143752 cites W2015507812 @default.
- W4324143752 cites W2023123334 @default.
- W4324143752 cites W2023133790 @default.
- W4324143752 cites W2023903216 @default.
- W4324143752 cites W2023952374 @default.
- W4324143752 cites W2024383984 @default.
- W4324143752 cites W2025217427 @default.
- W4324143752 cites W2026066934 @default.
- W4324143752 cites W2026304699 @default.
- W4324143752 cites W2026624072 @default.
- W4324143752 cites W2028101194 @default.
- W4324143752 cites W2028604893 @default.
- W4324143752 cites W2031117917 @default.
- W4324143752 cites W2032692966 @default.
- W4324143752 cites W2034295995 @default.
- W4324143752 cites W2034618121 @default.
- W4324143752 cites W2034869374 @default.
- W4324143752 cites W2035187942 @default.
- W4324143752 cites W2036016356 @default.
- W4324143752 cites W2036430692 @default.
- W4324143752 cites W2038489530 @default.
- W4324143752 cites W2040115645 @default.
- W4324143752 cites W2040168494 @default.
- W4324143752 cites W2040226391 @default.
- W4324143752 cites W2041559162 @default.
- W4324143752 cites W2042428289 @default.
- W4324143752 cites W2043827679 @default.
- W4324143752 cites W2046350491 @default.
- W4324143752 cites W2046536988 @default.
- W4324143752 cites W2046778136 @default.
- W4324143752 cites W2051954925 @default.