Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324144504> ?p ?o ?g. }
- W4324144504 endingPage "49" @default.
- W4324144504 startingPage "39" @default.
- W4324144504 abstract "Differentiation-inducing factor 1 (DIF-1) is a morphogen produced by Dictyostelium discoideum that inhibits the proliferation and migration of both D. discoideum and most mammalian cells. Herein, we assessed the effect of DIF-1 on mitochondria, because DIF-3, which is similar to DIF-1, reportedly localizes in the mitochondria when added exogenously, however the significance of this localization remains unclear. Cofilin is an actin depolymerization factor that is activated by dephosphorylation at Ser-3. By regulating the actin cytoskeleton, cofilin induces mitochondrial fission, the first step in mitophagy. Here, we report that DIF-1 activates cofilin and induces mitochondrial fission and mitophagy mainly using human umbilical vein endothelial cells (HUVECs). AMP-activated kinase (AMPK), a downstream molecule of DIF-1 signaling, is required for cofilin activation. Pyridoxal phosphatase (PDXP)—known to directly dephosphorylate cofilin—is also required for the effect of DIF-1 on cofilin, indicating that DIF-1 activates cofilin through AMPK and PDXP. Cofilin knockdown inhibits mitochondrial fission and decreases mitofusin 2 (Mfn2) protein levels, a hallmark of mitophagy. Taken together, these results indicate that cofilin is required for DIF-1- induced mitochondrial fission and mitophagy." @default.
- W4324144504 created "2023-03-15" @default.
- W4324144504 creator A5009037238 @default.
- W4324144504 creator A5009171954 @default.
- W4324144504 creator A5012808854 @default.
- W4324144504 creator A5056028813 @default.
- W4324144504 creator A5057302383 @default.
- W4324144504 creator A5059901496 @default.
- W4324144504 creator A5071982396 @default.
- W4324144504 creator A5075923438 @default.
- W4324144504 date "2023-05-01" @default.
- W4324144504 modified "2023-09-25" @default.
- W4324144504 title "Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission" @default.
- W4324144504 cites W1044474270 @default.
- W4324144504 cites W1916172146 @default.
- W4324144504 cites W1971658576 @default.
- W4324144504 cites W1974473949 @default.
- W4324144504 cites W1989478104 @default.
- W4324144504 cites W1992744033 @default.
- W4324144504 cites W2001587093 @default.
- W4324144504 cites W2002788522 @default.
- W4324144504 cites W2012163664 @default.
- W4324144504 cites W2017206858 @default.
- W4324144504 cites W2020638143 @default.
- W4324144504 cites W2037064466 @default.
- W4324144504 cites W2054966870 @default.
- W4324144504 cites W2074348836 @default.
- W4324144504 cites W2081920342 @default.
- W4324144504 cites W2106324494 @default.
- W4324144504 cites W2112304096 @default.
- W4324144504 cites W2140733896 @default.
- W4324144504 cites W2331208678 @default.
- W4324144504 cites W2609169199 @default.
- W4324144504 cites W2613454381 @default.
- W4324144504 cites W2626831033 @default.
- W4324144504 cites W2739462301 @default.
- W4324144504 cites W2755721896 @default.
- W4324144504 cites W2773436899 @default.
- W4324144504 cites W2784192559 @default.
- W4324144504 cites W2788644497 @default.
- W4324144504 cites W2790898030 @default.
- W4324144504 cites W2811266668 @default.
- W4324144504 cites W2964186349 @default.
- W4324144504 cites W2977071875 @default.
- W4324144504 cites W2982884868 @default.
- W4324144504 cites W2985421076 @default.
- W4324144504 cites W3012923032 @default.
- W4324144504 cites W3026570638 @default.
- W4324144504 cites W3100123728 @default.
- W4324144504 cites W3106278194 @default.
- W4324144504 cites W3120666307 @default.
- W4324144504 cites W3150906843 @default.
- W4324144504 cites W3185986523 @default.
- W4324144504 cites W4200266695 @default.
- W4324144504 doi "https://doi.org/10.1016/j.jphs.2023.02.009" @default.
- W4324144504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37059490" @default.
- W4324144504 hasPublicationYear "2023" @default.
- W4324144504 type Work @default.
- W4324144504 citedByCount "0" @default.
- W4324144504 crossrefType "journal-article" @default.
- W4324144504 hasAuthorship W4324144504A5009037238 @default.
- W4324144504 hasAuthorship W4324144504A5009171954 @default.
- W4324144504 hasAuthorship W4324144504A5012808854 @default.
- W4324144504 hasAuthorship W4324144504A5056028813 @default.
- W4324144504 hasAuthorship W4324144504A5057302383 @default.
- W4324144504 hasAuthorship W4324144504A5059901496 @default.
- W4324144504 hasAuthorship W4324144504A5071982396 @default.
- W4324144504 hasAuthorship W4324144504A5075923438 @default.
- W4324144504 hasBestOaLocation W43241445041 @default.
- W4324144504 hasConcept C104317684 @default.
- W4324144504 hasConcept C142669718 @default.
- W4324144504 hasConcept C1491633281 @default.
- W4324144504 hasConcept C169415338 @default.
- W4324144504 hasConcept C17619807 @default.
- W4324144504 hasConcept C185592680 @default.
- W4324144504 hasConcept C190283241 @default.
- W4324144504 hasConcept C203522944 @default.
- W4324144504 hasConcept C2775969001 @default.
- W4324144504 hasConcept C2776601116 @default.
- W4324144504 hasConcept C2777229759 @default.
- W4324144504 hasConcept C2779324830 @default.
- W4324144504 hasConcept C28859421 @default.
- W4324144504 hasConcept C2993400109 @default.
- W4324144504 hasConcept C55493867 @default.
- W4324144504 hasConcept C86803240 @default.
- W4324144504 hasConcept C95444343 @default.
- W4324144504 hasConceptScore W4324144504C104317684 @default.
- W4324144504 hasConceptScore W4324144504C142669718 @default.
- W4324144504 hasConceptScore W4324144504C1491633281 @default.
- W4324144504 hasConceptScore W4324144504C169415338 @default.
- W4324144504 hasConceptScore W4324144504C17619807 @default.
- W4324144504 hasConceptScore W4324144504C185592680 @default.
- W4324144504 hasConceptScore W4324144504C190283241 @default.
- W4324144504 hasConceptScore W4324144504C203522944 @default.
- W4324144504 hasConceptScore W4324144504C2775969001 @default.
- W4324144504 hasConceptScore W4324144504C2776601116 @default.
- W4324144504 hasConceptScore W4324144504C2777229759 @default.
- W4324144504 hasConceptScore W4324144504C2779324830 @default.