FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324146003> ?p ?o ?g. }

• W4324146003 abstract "Abstract Insertion sequence contributes to the emergence of carbapenem resistance by dissemination of carbapenemase genes and providing promoter for their overexpression. This study aims to ascertain the occurrence of IS Aba1 -linked OXA carbapenemase genes and its relevance to carbapenem resistance level in Acinetobacter baumannii . This hospital based descriptive study was conducted at Shahid Gangalal National Heart Center, Kathmandu, Nepal. An overall of 1,291 clinical specimens received for routine culture and antibiotic susceptibility testing throughout the study period were included in this study. Identification of Acinetobacter baumannii was validated through detection of intrinsic bla OXA-51-like gene by polymerase chain reaction (PCR). Antibiotic susceptibility was tested by Kirby-Bauer disc diffusion approach and minimum inhibitory concentration (MIC) of meropenem was assessed through agar dilution method. Uniplex PCR assays were performed to detect genes encoding oxacillinases and IS Aba1 . Upstream association of insertion element, IS Aba1 to oxacillinase genes was assessed through PCR mapping strategy using IS Aba1 F and OXA-51R/OXA-23R primers. Out of the 340 bacteria isolated, only 40 (11.8%) were Acinetobacter baumannii . All isolates were resistant against meropenem with MIC value ranging from 16-256 μg/ml. bla OXA-23-like genes was present in every isolate but bla OXA-58 in just two isolates (5%). All isolates had IS Aba1 either above bla OXA-23-like or bla OXA-51-like gene. Higher MIC 90 value of meropenem (243.20 μg/ml) was found in A . baumannii cluster with IS Aba1 -linked upstream to both bla OXA-23-like and bla OXA-51-like genes, thus depicting their eminent role to enhanced carbapenem resistance. Acinetobacter baumannii isolates with IS Aba1 -linked oxacillinase genes are rapidly emerging in clinical settings of Nepal. Thus, medical communities need to be prepared and enable targeted approaches for managing burgeoning problem of carbapenem resistance." @default.
• W4324146003 created "2023-03-15" @default.
• W4324146003 creator A5004296139 @default.
• W4324146003 creator A5025943862 @default.
• W4324146003 creator A5032033889 @default.
• W4324146003 creator A5050375613 @default.
• W4324146003 creator A5051007125 @default.
• W4324146003 creator A5054502105 @default.
• W4324146003 creator A5064945267 @default.
• W4324146003 date "2023-03-13" @default.
• W4324146003 modified "2023-09-29" @default.
• W4324146003 title "Emergence of IS<i>Aba1</i>-linked oxacillinase genes among carbapenem resistant<i>Acinetobacter baumannii</i>isolates in a tertiary cardiac center, Nepal" @default.
• W4324146003 cites W1771795677 @default.
• W4324146003 cites W1997495012 @default.
• W4324146003 cites W1998160403 @default.
• W4324146003 cites W2002150835 @default.
• W4324146003 cites W2006881751 @default.
• W4324146003 cites W2010425482 @default.
• W4324146003 cites W2016555214 @default.
• W4324146003 cites W2020594010 @default.
• W4324146003 cites W2024063598 @default.
• W4324146003 cites W2092296774 @default.
• W4324146003 cites W2100311333 @default.
• W4324146003 cites W2110655134 @default.
• W4324146003 cites W2111172009 @default.
• W4324146003 cites W2111712277 @default.
• W4324146003 cites W2115118328 @default.
• W4324146003 cites W2115806913 @default.
• W4324146003 cites W2116402170 @default.
• W4324146003 cites W2118870508 @default.
• W4324146003 cites W2119577537 @default.
• W4324146003 cites W2120403643 @default.
• W4324146003 cites W2129734287 @default.
• W4324146003 cites W2133180399 @default.
• W4324146003 cites W2133869170 @default.
• W4324146003 cites W2149500566 @default.
• W4324146003 cites W2153444025 @default.
• W4324146003 cites W2159435953 @default.
• W4324146003 cites W2162484291 @default.
• W4324146003 cites W2163524987 @default.
• W4324146003 cites W2168052711 @default.
• W4324146003 cites W2176147919 @default.
• W4324146003 cites W2227953089 @default.
• W4324146003 cites W2264178851 @default.
• W4324146003 cites W2303950571 @default.
• W4324146003 cites W2511964062 @default.
• W4324146003 cites W2512577309 @default.
• W4324146003 cites W2586143936 @default.
• W4324146003 cites W2754511203 @default.
• W4324146003 cites W2885680427 @default.
• W4324146003 cites W2938627988 @default.
• W4324146003 cites W2944245357 @default.
• W4324146003 cites W2990735645 @default.
• W4324146003 cites W2994575890 @default.
• W4324146003 cites W2997782158 @default.
• W4324146003 doi "https://doi.org/10.1101/2023.03.13.532405" @default.
• W4324146003 hasPublicationYear "2023" @default.
• W4324146003 type Work @default.
• W4324146003 citedByCount "0" @default.
• W4324146003 crossrefType "posted-content" @default.
• W4324146003 hasAuthorship W4324146003A5004296139 @default.
• W4324146003 hasAuthorship W4324146003A5025943862 @default.
• W4324146003 hasAuthorship W4324146003A5032033889 @default.
• W4324146003 hasAuthorship W4324146003A5050375613 @default.
• W4324146003 hasAuthorship W4324146003A5051007125 @default.
• W4324146003 hasAuthorship W4324146003A5054502105 @default.
• W4324146003 hasAuthorship W4324146003A5064945267 @default.
• W4324146003 hasBestOaLocation W43241460031 @default.
• W4324146003 hasConcept C104317684 @default.
• W4324146003 hasConcept C176947019 @default.
• W4324146003 hasConcept C2776315533 @default.
• W4324146003 hasConcept C2776685102 @default.
• W4324146003 hasConcept C2777637488 @default.
• W4324146003 hasConcept C2779375183 @default.
• W4324146003 hasConcept C2780493024 @default.
• W4324146003 hasConcept C49105822 @default.
• W4324146003 hasConcept C501593827 @default.
• W4324146003 hasConcept C523546767 @default.
• W4324146003 hasConcept C54355233 @default.
• W4324146003 hasConcept C86803240 @default.
• W4324146003 hasConcept C89423630 @default.
• W4324146003 hasConcept C94665300 @default.
• W4324146003 hasConceptScore W4324146003C104317684 @default.
• W4324146003 hasConceptScore W4324146003C176947019 @default.
• W4324146003 hasConceptScore W4324146003C2776315533 @default.
• W4324146003 hasConceptScore W4324146003C2776685102 @default.
• W4324146003 hasConceptScore W4324146003C2777637488 @default.
• W4324146003 hasConceptScore W4324146003C2779375183 @default.
• W4324146003 hasConceptScore W4324146003C2780493024 @default.
• W4324146003 hasConceptScore W4324146003C49105822 @default.
• W4324146003 hasConceptScore W4324146003C501593827 @default.
• W4324146003 hasConceptScore W4324146003C523546767 @default.
• W4324146003 hasConceptScore W4324146003C54355233 @default.
• W4324146003 hasConceptScore W4324146003C86803240 @default.
• W4324146003 hasConceptScore W4324146003C89423630 @default.
• W4324146003 hasConceptScore W4324146003C94665300 @default.
• W4324146003 hasLocation W43241460031 @default.
• W4324146003 hasOpenAccess W4324146003 @default.
• W4324146003 hasPrimaryLocation W43241460031 @default.
• W4324146003 hasRelatedWork W1788363151 @default.

• next