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• W4324276906 abstract "<h3>Background:</h3> The connective tissue diseases (CTDs) are a group of inflammatory, immune-mediated disorders. Involvement of the respiratory system, particularly interstitial lung disease (ILD), is common and is an important contributor to morbidity and mortality.Currently, high-resolution computed tomography (HRCT), bronchoscopic examination and surgical lung biopsy (SLB) are the basic methods for the diagnosis of ILD,But these tests require specific inspection machines,are less repeatable and cause considerable discomfort to the subject. <h3>Objectives:</h3> To evaluate the diagnosis of the serum Krebs von den Lungen-6 (KL-6)for the interstitial lung disease(ILD) associated with connective tissue diseases(CTD). <h3>Methods:</h3> Patients with CTDs who visited our Hospital between January, 2016 and December, 2017, and whose serum KL-6 level was measured were included. We analyzed 175 patients with CTDs,84 CTDs associated ILD,91 CTDs patients without ILD. Record age,gender,diagnosis,serum KL-6 levels,pulmonary function tests and performed in parallel were reviewed. Statistical analysis was performed using SPSS (version20.0) statistical package <h3>Results:</h3> The significantly higher levels of KL-6 were determined in the CTD-ILD group than in the CTDs without pulmonary involvement group(<i>P</i> <0.05)( figure 1 ).By the ROC curves of serum KL-6 levels in 175 patients. The optimal cutoff value of serum KL-6 for a diagnosis of CTD-ILD was 409U/ml, and the sensitivity and specificity were82.1% and 86.8%, respectively. The AUC was 0.905(figure 2).Serum KL-6 correlated negatively with vital capacity(VC) (%predicted),forced vital capacity(FVC%)(%predicted),forced expiratory volume in one second(FEV1%)(%predicted) and diffusing capacity of the lung for carbon monoxide (DLcoSB) (% predicted) (Table 1). <h3>Conclusion:</h3> The serum KL-6 is a valuable biomarker for CTD-ILD diagnosis , and it is an important serum marker for detection of CTD-ILD activity. <h3>References</h3> [1] Capobianco,J, et al. Thoracic manifestations of collagen vascular diseases. Radio -graphics 32.1(2012):33-50. [2] Woodhead F, Wells A U, Desai S R. Pulmonary Complications of Connective Tissue Diseases[J]. Clinics in Chest Medicine, 2008, 29(29):149–164. [3] Kohno N, Kyoizumi S, Awaya Y, et al. New serum indicator of interstitial pneum -onitis activity. Sialylated carbohydrate antigen KL-6. Chest 1989; 96:68–73. [4] Ogz E O, Kucuksahin O, Turgay M, et al. Association of serum KL-6 levels with interstitial lung disease in patients with connective tissue disease: a cross-sectional study. Clinical Rheumatology, 2016, 35(3):663-666. <h3>Disclosure of Interests:</h3> None declared" @default.
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• W4324276906 date "2019-05-27" @default.
• W4324276906 modified "2023-09-30" @default.
• W4324276906 title "SAT0672 THE DIAGNOSTIC VALUE OF SERUM KL-6 IN CONNECTIVE TISSUE DISEASE ASSOCIATED INTERSTITIAL LUNG DISEASE" @default.
• W4324276906 doi "https://doi.org/10.1136/annrheumdis-2019-eular.7673" @default.
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