FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324280114> ?p ?o ?g. }

• W4324280114 endingPage "204201882311581" @default.
• W4324280114 startingPage "204201882311581" @default.
• W4324280114 abstract "Background: Thyroid hormones are controlled by the hypothalamic–pituitary–thyroid (HPT) axis through a complex network of regulatory loops, involving the hormones TRH, TSH, FT4, and FT3. The relationship between TSH and FT4 is widely used for diagnosing thyroid diseases. However, mechanisms of FT3 homeostasis are not well understood. Objective: We used mathematical modelling to further examine mechanisms that exist in the HPT axis regulation for protecting circulating FT3 levels. Methods: A mathematical model consisting of a system of four coupled first-order parameterized non-linear ordinary differential equations (ODEs) was developed, accounting for the interdependencies between the hormones in the HPT axis regulation. While TRH and TSH feed forward to the pituitary and thyroid, respectively, FT4 and FT3 feed backward to both the pituitary and hypothalamus. Stable equilibrium solutions of the ODE system express homeostasis for a particular variable, such as FT3, if this variable stays in a narrow range while certain other parameter(s) and system variable(s) may vary substantially. Results: The model predicts that (1) TSH-feedforward protects FT3 levels if the FT4 production rate declines and (2) combined negative feedback by FT4 and FT3 on both TSH and TRH production rates keeps FT3 levels insensitive to moderate changes in FT4 production rates and FT4 levels. The optimum FT4 and FT3 feedback and TRH and TSH-feedforward ranges that preserve FT3 homeostasis were found by numerical continuation analysis. Model predictions were in close agreement with clinical studies and individual patient examples of hypothyroidism and hyperthyroidism. Conclusions: These findings further extend the concept of HPT axis regulation beyond TSH and FT4 to integrate the more active sister hormone FT3 and mechanisms of FT3 homeostasis. Disruption of homeostatic mechanisms leads to disease. This provides a perspective for novel testable concepts in clinical studies to therapeutically target the disruptive mechanisms." @default.
• W4324280114 created "2023-03-16" @default.
• W4324280114 creator A5039964000 @default.
• W4324280114 creator A5067369643 @default.
• W4324280114 creator A5067455412 @default.
• W4324280114 creator A5074292475 @default.
• W4324280114 date "2023-01-01" @default.
• W4324280114 modified "2023-09-26" @default.
• W4324280114 title "The role of supporting and disruptive mechanisms of FT3 homeostasis in regulating the hypothalamic–pituitary–thyroid axis" @default.
• W4324280114 cites W1747119434 @default.
• W4324280114 cites W1970942447 @default.
• W4324280114 cites W1980520134 @default.
• W4324280114 cites W1980687578 @default.
• W4324280114 cites W1982344482 @default.
• W4324280114 cites W1986793251 @default.
• W4324280114 cites W2006028504 @default.
• W4324280114 cites W2021314292 @default.
• W4324280114 cites W2023364545 @default.
• W4324280114 cites W2034478204 @default.
• W4324280114 cites W2060478264 @default.
• W4324280114 cites W2065206163 @default.
• W4324280114 cites W2071227705 @default.
• W4324280114 cites W2072303948 @default.
• W4324280114 cites W2075932932 @default.
• W4324280114 cites W2104878795 @default.
• W4324280114 cites W2117317136 @default.
• W4324280114 cites W2124586956 @default.
• W4324280114 cites W2173996299 @default.
• W4324280114 cites W2177288738 @default.
• W4324280114 cites W2268681646 @default.
• W4324280114 cites W2313724109 @default.
• W4324280114 cites W2513970042 @default.
• W4324280114 cites W2528271650 @default.
• W4324280114 cites W2554592783 @default.
• W4324280114 cites W2607827320 @default.
• W4324280114 cites W2611647435 @default.
• W4324280114 cites W2616986899 @default.
• W4324280114 cites W2737920559 @default.
• W4324280114 cites W2738911959 @default.
• W4324280114 cites W2739407595 @default.
• W4324280114 cites W2775358200 @default.
• W4324280114 cites W2779801487 @default.
• W4324280114 cites W2785984371 @default.
• W4324280114 cites W2790723135 @default.
• W4324280114 cites W2793681123 @default.
• W4324280114 cites W2884759618 @default.
• W4324280114 cites W2890555553 @default.
• W4324280114 cites W2944223163 @default.
• W4324280114 cites W2953536588 @default.
• W4324280114 cites W2968394236 @default.
• W4324280114 cites W2982229911 @default.
• W4324280114 cites W2989561443 @default.
• W4324280114 cites W2996502729 @default.
• W4324280114 cites W3006107828 @default.
• W4324280114 cites W3012033770 @default.
• W4324280114 cites W3021924627 @default.
• W4324280114 cites W3042814743 @default.
• W4324280114 cites W3094956452 @default.
• W4324280114 cites W3134936980 @default.
• W4324280114 cites W4207062644 @default.
• W4324280114 cites W4282978220 @default.
• W4324280114 cites W4285744164 @default.
• W4324280114 cites W4291383240 @default.
• W4324280114 cites W4307799310 @default.
• W4324280114 cites W4311850727 @default.
• W4324280114 cites W2100106898 @default.
• W4324280114 doi "https://doi.org/10.1177/20420188231158163" @default.
• W4324280114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36936128" @default.
• W4324280114 hasPublicationYear "2023" @default.
• W4324280114 type Work @default.
• W4324280114 citedByCount "0" @default.
• W4324280114 crossrefType "journal-article" @default.
• W4324280114 hasAuthorship W4324280114A5039964000 @default.
• W4324280114 hasAuthorship W4324280114A5067369643 @default.
• W4324280114 hasAuthorship W4324280114A5067455412 @default.
• W4324280114 hasAuthorship W4324280114A5074292475 @default.
• W4324280114 hasBestOaLocation W43242801141 @default.
• W4324280114 hasConcept C113214860 @default.
• W4324280114 hasConcept C126322002 @default.
• W4324280114 hasConcept C134018914 @default.
• W4324280114 hasConcept C2777003273 @default.
• W4324280114 hasConcept C2779571634 @default.
• W4324280114 hasConcept C526584372 @default.
• W4324280114 hasConcept C63645605 @default.
• W4324280114 hasConcept C71315377 @default.
• W4324280114 hasConcept C71924100 @default.
• W4324280114 hasConceptScore W4324280114C113214860 @default.
• W4324280114 hasConceptScore W4324280114C126322002 @default.
• W4324280114 hasConceptScore W4324280114C134018914 @default.
• W4324280114 hasConceptScore W4324280114C2777003273 @default.
• W4324280114 hasConceptScore W4324280114C2779571634 @default.
• W4324280114 hasConceptScore W4324280114C526584372 @default.
• W4324280114 hasConceptScore W4324280114C63645605 @default.
• W4324280114 hasConceptScore W4324280114C71315377 @default.
• W4324280114 hasConceptScore W4324280114C71924100 @default.
• W4324280114 hasLocation W43242801141 @default.
• W4324280114 hasLocation W43242801142 @default.
• W4324280114 hasLocation W43242801143 @default.

• next