FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324316393> ?p ?o ?g. }

• W4324316393 abstract "ABSTRACT Transcription factors (TFs) regulate eukaryotic transcription through selecting DNA-binding, can also specifically interact with RNA, which may present another layer of transcriptional control. The mechanisms of the TFs-DNA recognition are often well-characterised, while the details of TFs-RNA complexation are less understood. Here we investigate the dual recognition mechanism of the glucocorticoid receptor (GR), which interacts with similar affinities with consensus DNA and diverse RNA hairpin motifs but discriminates against uniform dsRNA. Using atomic molecular dynamics simulations, we demonstrate that the GR binding to nucleic acids requires a wide and shallow groove pocket. The protein effectively moulds its binding site within DNA major groove, which enables base-specific interactions. Contrary, the GR binding has little effect on the grooves geometry of RNA systems, most notably in uniform dsRNA. Instead, a hairpin motif in RNA yields a wide and shallow major groove pocket, allowing the protein to anchor itself through nonspecific electrostatic contacts with RNA backbone. Addition of a bulge increases RNA hairpin flexibility, which leads to a greater number of GR-RNA contacts and, thus, higher affinity. Thus, the combination of structural motifs defines the GR-RNA selective binding: a recognition mechanism, which may be shared by other zinc finger TFs" @default.
• W4324316393 created "2023-03-16" @default.
• W4324316393 creator A5047756527 @default.
• W4324316393 creator A5059480698 @default.
• W4324316393 date "2023-03-15" @default.
• W4324316393 modified "2023-09-26" @default.
• W4324316393 title "Decoding the Dual Recognition Mechanism of Glucocorticoid Receptor for DNA and RNA: Sequence vs. Shape" @default.
• W4324316393 cites W1000149840 @default.
• W4324316393 cites W1801967472 @default.
• W4324316393 cites W1967495043 @default.
• W4324316393 cites W1981225934 @default.
• W4324316393 cites W1990157223 @default.
• W4324316393 cites W1994248538 @default.
• W4324316393 cites W1998643862 @default.
• W4324316393 cites W2009239521 @default.
• W4324316393 cites W2010076108 @default.
• W4324316393 cites W2015175027 @default.
• W4324316393 cites W2017182956 @default.
• W4324316393 cites W2021708267 @default.
• W4324316393 cites W2025919590 @default.
• W4324316393 cites W2032183039 @default.
• W4324316393 cites W2034836489 @default.
• W4324316393 cites W2035266068 @default.
• W4324316393 cites W2037686178 @default.
• W4324316393 cites W2041781038 @default.
• W4324316393 cites W2046792302 @default.
• W4324316393 cites W2052500616 @default.
• W4324316393 cites W2060079863 @default.
• W4324316393 cites W2062105576 @default.
• W4324316393 cites W2081046982 @default.
• W4324316393 cites W2081693079 @default.
• W4324316393 cites W2086561953 @default.
• W4324316393 cites W2097985410 @default.
• W4324316393 cites W2121352589 @default.
• W4324316393 cites W2123436615 @default.
• W4324316393 cites W2132134302 @default.
• W4324316393 cites W2132629607 @default.
• W4324316393 cites W2133141667 @default.
• W4324316393 cites W2136729627 @default.
• W4324316393 cites W2141337702 @default.
• W4324316393 cites W2147339635 @default.
• W4324316393 cites W2154241726 @default.
• W4324316393 cites W2167807351 @default.
• W4324316393 cites W2204493772 @default.
• W4324316393 cites W2204959575 @default.
• W4324316393 cites W2292301738 @default.
• W4324316393 cites W2332712348 @default.
• W4324316393 cites W2389146082 @default.
• W4324316393 cites W2515307706 @default.
• W4324316393 cites W2568322374 @default.
• W4324316393 cites W2615136515 @default.
• W4324316393 cites W2618657542 @default.
• W4324316393 cites W2785792383 @default.
• W4324316393 cites W2808039759 @default.
• W4324316393 cites W2810498756 @default.
• W4324316393 cites W2890932733 @default.
• W4324316393 cites W2947425925 @default.
• W4324316393 cites W2998235890 @default.
• W4324316393 cites W3014677172 @default.
• W4324316393 cites W3082572947 @default.
• W4324316393 cites W3095774269 @default.
• W4324316393 cites W3111998353 @default.
• W4324316393 cites W3191441526 @default.
• W4324316393 cites W3213363702 @default.
• W4324316393 cites W4205718783 @default.
• W4324316393 cites W4286497619 @default.
• W4324316393 cites W4297491748 @default.
• W4324316393 cites W4310202145 @default.
• W4324316393 doi "https://doi.org/10.1101/2023.03.15.532803" @default.
• W4324316393 hasPublicationYear "2023" @default.
• W4324316393 type Work @default.
• W4324316393 citedByCount "0" @default.
• W4324316393 crossrefType "posted-content" @default.
• W4324316393 hasAuthorship W4324316393A5047756527 @default.
• W4324316393 hasAuthorship W4324316393A5059480698 @default.
• W4324316393 hasBestOaLocation W43243163931 @default.
• W4324316393 hasConcept C104317684 @default.
• W4324316393 hasConcept C12554922 @default.
• W4324316393 hasConcept C138885662 @default.
• W4324316393 hasConcept C166703698 @default.
• W4324316393 hasConcept C179926584 @default.
• W4324316393 hasConcept C185581394 @default.
• W4324316393 hasConcept C2191507 @default.
• W4324316393 hasConcept C24284526 @default.
• W4324316393 hasConcept C41895202 @default.
• W4324316393 hasConcept C54355233 @default.
• W4324316393 hasConcept C552990157 @default.
• W4324316393 hasConcept C67705224 @default.
• W4324316393 hasConcept C70721500 @default.
• W4324316393 hasConcept C86339819 @default.
• W4324316393 hasConcept C86803240 @default.
• W4324316393 hasConcept C95444343 @default.
• W4324316393 hasConceptScore W4324316393C104317684 @default.
• W4324316393 hasConceptScore W4324316393C12554922 @default.
• W4324316393 hasConceptScore W4324316393C138885662 @default.
• W4324316393 hasConceptScore W4324316393C166703698 @default.
• W4324316393 hasConceptScore W4324316393C179926584 @default.
• W4324316393 hasConceptScore W4324316393C185581394 @default.
• W4324316393 hasConceptScore W4324316393C2191507 @default.
• W4324316393 hasConceptScore W4324316393C24284526 @default.

• next